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Visual Morbidity With Chiasmal Glioma: Title and subTitle BreakLong-Term Studies of Visual Fields in Untreated and Irradiated Cases FREE

Joel S. Glaser, MD; William F. Hoyt, MD; James Corbett, MD
[+] Author Affiliations

Submitted for publication June 29, 1970.

Reprint requests to Division of Neurological Surgery, University of California, San Francisco 94122. (Dr. Hoyt).


Arch Ophthalmol. 1971;85(1):3-12. doi:10.1001/archopht.1971.00990050005002
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Analysis and comparison of the natural history of visual field changes in ten untreated and ten irradiated chiasmal gliomas revealed (1) no consistent relationship between the pattern and severity of field defects and the location, size, or extent of the tumor, and (2) a monotonously stable course of field defects and visual acuity in most cases. Over prolonged periods of follow up, the untreated patients fared as well as the irradiated group. There was no clinical evidence to support the alleged efficacy of radiation therapy for these indolent congenital tumors.

REFERENCES

Hoyt WF, Baghdassarian SB:  Optic glioma of childhood: Natural history and rationale for conservative management . Brit J Ophthal 53:793-798, 1969;.
Verhoeff FH:  Primary intraneural tumors (gliomas) of the optic nerve: A histologic study of 11 cases, including a case showing cystic involvement of the optic disc, with demonstration of the origin of cytoid bodies of the retina and cavernous atrophy of the optic nerve . Arch Ophthal 51:120-140, 239-254, 1922;.
Davis FA:  Primary tumors of the optic nerve (a phenomenon of Recklinghausen's disease): A clinical and pathological study with a report of five cases and a review of the literature . Arch Ophthal 23:735-821, 957-1022, 1940;.
Anderson DR, Spencer WH:  Ultrastructural and histochemical observations of optic nerve gliomas . Arch Ophthal 83:324-335, 1970;.
Öppel O:  Mikroskopische Untersuchungen über die Anzahl und Kaliber der markhaltigen Nervenfasern im Fasciculus opticus des Menschen . Graefe Arch Klin Exp Ophthal 166:19-27, 1963;.
Martin T, Cushing H:  Primary gliomas of the chiasm and optic nerves in their intracranial portion . Arch Ophthal 52:209-241, 1923;.
Tym R:  Piloid gliomas of the anterior optic pathways . Brit J Surg 49:322-331, 1961;.
Taveras JM, Mount LA, Wood EM:  The value of radiation therapy in the management of glioma of the optic nerves and chiasm . Radiology 66:518-528, 1956;.
Throuvalas N, Bataini P, Ennuyer A:  Les gliomes du chiasma et du nerf optique: L'apport de la radiothérapie transcutanée dans leur traitement . Bull Cancer 56:231-264, 1969;.
Chutorian AM, Schwartz JF, Evans RA, et al:  Optic gliomas in children . Neurology 14:83-95, 1964;.

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Hoyt WF, Baghdassarian SB:  Optic glioma of childhood: Natural history and rationale for conservative management . Brit J Ophthal 53:793-798, 1969;.
Verhoeff FH:  Primary intraneural tumors (gliomas) of the optic nerve: A histologic study of 11 cases, including a case showing cystic involvement of the optic disc, with demonstration of the origin of cytoid bodies of the retina and cavernous atrophy of the optic nerve . Arch Ophthal 51:120-140, 239-254, 1922;.
Davis FA:  Primary tumors of the optic nerve (a phenomenon of Recklinghausen's disease): A clinical and pathological study with a report of five cases and a review of the literature . Arch Ophthal 23:735-821, 957-1022, 1940;.
Anderson DR, Spencer WH:  Ultrastructural and histochemical observations of optic nerve gliomas . Arch Ophthal 83:324-335, 1970;.
Öppel O:  Mikroskopische Untersuchungen über die Anzahl und Kaliber der markhaltigen Nervenfasern im Fasciculus opticus des Menschen . Graefe Arch Klin Exp Ophthal 166:19-27, 1963;.
Martin T, Cushing H:  Primary gliomas of the chiasm and optic nerves in their intracranial portion . Arch Ophthal 52:209-241, 1923;.
Tym R:  Piloid gliomas of the anterior optic pathways . Brit J Surg 49:322-331, 1961;.
Taveras JM, Mount LA, Wood EM:  The value of radiation therapy in the management of glioma of the optic nerves and chiasm . Radiology 66:518-528, 1956;.
Throuvalas N, Bataini P, Ennuyer A:  Les gliomes du chiasma et du nerf optique: L'apport de la radiothérapie transcutanée dans leur traitement . Bull Cancer 56:231-264, 1969;.
Chutorian AM, Schwartz JF, Evans RA, et al:  Optic gliomas in children . Neurology 14:83-95, 1964;.

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