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May 1971, Vol 85, No. 5 >
ARTICLE | May 1971

Ocular Localization of Sodium Fluorescein: Title and subTitle BreakEffects of Administration in Rabbit and Monkey FREE

Michael C. Grayson, MB, ChB, FRCS(E); Alan M. Laties, MD
[+] Author Affiliations

Submitted for publication Oct 5, 1970.

Reprint requests to 419 Johnson Pavilion, University of Pennsylvania Medical School, 36th and Hamilton Walk, Philadelphia 19104 (Dr. Laties).


Arch Ophthalmol. 1971;85(5):600-609. doi:10.1001/archopht.1971.00990050602014
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The localization of intravenously administered fluorescein was studied in rabbit and monkey by fluorescence microscopy of freeze-dried eyes. The blood vessels, large and small, of retina and optic nerve are impermeable to fluorescein. Although fluorescein diffuses rapidly throughout the choroid, none passes the pigment epithelium to enter the retina. In contrast, at the posterior scleral foramen some fluorescein enters the optic disc by diffusion from neighboring tissues.

REFERENCES

1 +
Wessing A: Fluorescein Angiography of the Retina . GK von Noorden (trans), St. Louis, CV Mosby, 1969;.
2 +
Cunha-Vaz JG, Maurice DM:  The active transport of fluorescein by the retinal vessels and the retina . J Physiol 191:467-486, 1967;.
3 +
Maurice DM:  The use of fluorescein in ophthalmological research . Invest Ophthal 6:464-477, 1967;.
4 +
Dollery CT, Hodge JV, Engel M:  Studies of the retinal circulation with fluorescein . Brit Med J 2:1210-1215, 1962;.
5 +
Hanzon V, Hermodsson LH: Freeze-drying of tissues for light and electron microscopy .  J Ultrastruc Res 4:332-348, 1960;.
6 +
Rodriguez-Peralta LA:  Hematic and fluid barriers in the optic nerve . J Comp Neurol 126:109-122, 1966;.
7 +
Rodriguez-Peralta LA:  Hematic and fluid barriers of the retina and vitreous body . J Comp Neurol 132:109-124, 1968;.
8 +
Palm E:  On the occurrence in the retina of conditions corresponding to the "blood-brain barrier." Acta Ophthal 25:29-35, 1947;.
9 +
Sollom AW:  Ocular tissue staining in the rabbit after fluorescein injection . Exp Eye Res 7:551-555, 1968;.
10 +
Machemer R:  Angiographic-histologic correlation of eye vessel permeability with protein-bound fluorescent dye . Amer J Ophthal 69:27-38, 1970;.
11 +
Brierley JB:  The blood-brain barrier: Structural aspects , in Richter D (ed): Metabolism of the Nervous System . New York, Pergamon Press, 1957;, pp 121-135.
12 +
Wislocki GB, Ladman AJ:  The demonstration of a blood-ocular barrier in the albino rat by means of the intravitam deposition of silver . J Biophys Biochem Cytol 1:501-516, 1955;.
13 +
Missotten L:  Etudes des capillaires de la rétine et de la choriocapillaire au microscope électronique . Ophthalmologica 144:1-12, 1962;.
14 +
Cunha-Vaz JG, Shakib M, Ashton N:  Studies on the permeability of the blood-retinal barrier: I. On the existence, development, and site of a bloodretinal barrier . Brit J Ophthal 50:441-453, 1966;.
15 +
Anderson DR:  Ultrastructure of meningeal sheaths: Normal human and monkey optic nerves . Arch Ophthal 82:659-674, 1969;.
16 +
Schaltenbrand G, Putnam T:  Untersuchungen zum Kreislauf des Liquor cerebrospinalis mit Hilfe intravenöser Fluorescineinspritzungen . Deutsch Z Nervenheilk 96:123-132, 1927;.
17 +
Anderson DR, Hoyt WF:  Ultrastructure of intraorbital portion of human and monkey optic nerve . Arch Ophthal 82:506-530, 1969;.

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1 +
Wessing A: Fluorescein Angiography of the Retina . GK von Noorden (trans), St. Louis, CV Mosby, 1969;.
2 +
Cunha-Vaz JG, Maurice DM:  The active transport of fluorescein by the retinal vessels and the retina . J Physiol 191:467-486, 1967;.
3 +
Maurice DM:  The use of fluorescein in ophthalmological research . Invest Ophthal 6:464-477, 1967;.
4 +
Dollery CT, Hodge JV, Engel M:  Studies of the retinal circulation with fluorescein . Brit Med J 2:1210-1215, 1962;.
5 +
Hanzon V, Hermodsson LH: Freeze-drying of tissues for light and electron microscopy .  J Ultrastruc Res 4:332-348, 1960;.
6 +
Rodriguez-Peralta LA:  Hematic and fluid barriers in the optic nerve . J Comp Neurol 126:109-122, 1966;.
7 +
Rodriguez-Peralta LA:  Hematic and fluid barriers of the retina and vitreous body . J Comp Neurol 132:109-124, 1968;.
8 +
Palm E:  On the occurrence in the retina of conditions corresponding to the "blood-brain barrier." Acta Ophthal 25:29-35, 1947;.
9 +
Sollom AW:  Ocular tissue staining in the rabbit after fluorescein injection . Exp Eye Res 7:551-555, 1968;.
10 +
Machemer R:  Angiographic-histologic correlation of eye vessel permeability with protein-bound fluorescent dye . Amer J Ophthal 69:27-38, 1970;.
11 +
Brierley JB:  The blood-brain barrier: Structural aspects , in Richter D (ed): Metabolism of the Nervous System . New York, Pergamon Press, 1957;, pp 121-135.
12 +
Wislocki GB, Ladman AJ:  The demonstration of a blood-ocular barrier in the albino rat by means of the intravitam deposition of silver . J Biophys Biochem Cytol 1:501-516, 1955;.
13 +
Missotten L:  Etudes des capillaires de la rétine et de la choriocapillaire au microscope électronique . Ophthalmologica 144:1-12, 1962;.
14 +
Cunha-Vaz JG, Shakib M, Ashton N:  Studies on the permeability of the blood-retinal barrier: I. On the existence, development, and site of a bloodretinal barrier . Brit J Ophthal 50:441-453, 1966;.
15 +
Anderson DR:  Ultrastructure of meningeal sheaths: Normal human and monkey optic nerves . Arch Ophthal 82:659-674, 1969;.
16 +
Schaltenbrand G, Putnam T:  Untersuchungen zum Kreislauf des Liquor cerebrospinalis mit Hilfe intravenöser Fluorescineinspritzungen . Deutsch Z Nervenheilk 96:123-132, 1927;.
17 +
Anderson DR, Hoyt WF:  Ultrastructure of intraorbital portion of human and monkey optic nerve . Arch Ophthal 82:506-530, 1969;.

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