0
ARTICLE |

Collagenase Inhibitors in Pseudomonas Keratitis: Title and subTitle BreakAdjuncts to Antibiotic Therapy in Rabbits FREE

LCDR George Bohigian, MC, USN; Mario Valenton, MD; Camp Lejeune, NC; Masao Okumoto, MAMaj ; Bobby L. Caraway, VC, USAF
[+] Author Affiliations

Submitted for publication June 1, 1972.

The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Navy Department or the naval service at large.

Reprint requests to Department of Ophthalmology, Washington University School of Medicine, 660 S Euclid, St. Louis 63110 (Dr. Bohigian).


Arch Ophthalmol. 1974;91(1):52-56. doi:10.1001/archopht.1974.03900060056014
Text Size: A A A
Published online

Collagenase inhibitors as adjuncts to antibiotic therapy were evaluated in experimentally induced Pseudomonas keratitis in rabbits. Neither the combination of 1% edetic acid (EDTA) and 0.25% polymyxin B sulfate nor that of 1.2% cysteine and 0.25% polymyxin B sulfate was more effective than the polymyxin B sulfate alone. There was a small statistical difference in favor of a combination of edetic acid-cysteine-polymyxin B sulfate when it was compared with an edetic acid-polymyxin B sulfate combination. This difference, although statistically significant, did not appear to be clinically important in the treatment of our experimental model.

REFERENCES

Fisher E Jr, Allen JH:  Mechanism of corneal destruction by Pseudomonas proteases . Am J Ophthalmol 46:249-255, 1958;.
Brown SI, Akiya S, Weller CA:  Prevention of the ulcers of the alkali-burned cornea: Preliminary studies with collagenase inhibitors . Arch Ophthalmol 82:95-97, 1969;.
Brown SI, Hook C:  Treatment of corneal destruction with collagenase inhibitors . Trans Am Acad Ophthalmol Otolaryngol 75:1199-1207, 1971;.
Slansky HH, Dohlman CH, Berman MB:  Prevention of corneal ulcers . Trans Am Acad Ophthalmol Otolaryngol 75:1208-1211, 1971;.
Itoi M, et al:  Prevention d'ulcères du stroma de la cornée grâce à l'utilisation d'un sel de calcium d'EDTA . Arch Ophthalmol 29:389-392, 1969;.
Hook CW, et al:  Characterization and inhibition of corneal collagenase . Invest Ophthalmol 10:496-503, 1971;.
Wilkinson SG:  The sensitivity of pseudomonads to ethylenediaminetetraacetic acid . J Gen Microbiol 47:67-76, 1967;.
Weiser R, Wimpenny J, Asscher AW:  Synergistic effect of edetic-acid/antibiotic combinations on Pseudomonas aeruginosa . Lancet 2:619-620, 1969;.
Wilson LA:  Chelation in experimental Pseudomonas keratitis . Br J Ophthalmol 54:587-593, 1970;.
Bohigian GM, Escapini H:  Corneal ulcer due to Pseudomonas aeruginosa: A comparison of the disease in California and El Salvador . Arch Ophthalmol 85:405-409, 1971;.
Bohigian G, Okumoto M, Valenton M:  Experimental Pseudomonas keratitis: Treatment with and evaluation of carbenicillin and gentamicin in combination . Arch Ophthalmol 86:432-437, 1971;.
Pearson ES, Hartley HO: Biometrika Tables for Statisticians . London, Cambridge University Press, 1954;, vol 1.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Fisher E Jr, Allen JH:  Mechanism of corneal destruction by Pseudomonas proteases . Am J Ophthalmol 46:249-255, 1958;.
Brown SI, Akiya S, Weller CA:  Prevention of the ulcers of the alkali-burned cornea: Preliminary studies with collagenase inhibitors . Arch Ophthalmol 82:95-97, 1969;.
Brown SI, Hook C:  Treatment of corneal destruction with collagenase inhibitors . Trans Am Acad Ophthalmol Otolaryngol 75:1199-1207, 1971;.
Slansky HH, Dohlman CH, Berman MB:  Prevention of corneal ulcers . Trans Am Acad Ophthalmol Otolaryngol 75:1208-1211, 1971;.
Itoi M, et al:  Prevention d'ulcères du stroma de la cornée grâce à l'utilisation d'un sel de calcium d'EDTA . Arch Ophthalmol 29:389-392, 1969;.
Hook CW, et al:  Characterization and inhibition of corneal collagenase . Invest Ophthalmol 10:496-503, 1971;.
Wilkinson SG:  The sensitivity of pseudomonads to ethylenediaminetetraacetic acid . J Gen Microbiol 47:67-76, 1967;.
Weiser R, Wimpenny J, Asscher AW:  Synergistic effect of edetic-acid/antibiotic combinations on Pseudomonas aeruginosa . Lancet 2:619-620, 1969;.
Wilson LA:  Chelation in experimental Pseudomonas keratitis . Br J Ophthalmol 54:587-593, 1970;.
Bohigian GM, Escapini H:  Corneal ulcer due to Pseudomonas aeruginosa: A comparison of the disease in California and El Salvador . Arch Ophthalmol 85:405-409, 1971;.
Bohigian G, Okumoto M, Valenton M:  Experimental Pseudomonas keratitis: Treatment with and evaluation of carbenicillin and gentamicin in combination . Arch Ophthalmol 86:432-437, 1971;.
Pearson ES, Hartley HO: Biometrika Tables for Statisticians . London, Cambridge University Press, 1954;, vol 1.

Correspondence

CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.