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January 1975, Vol 93, No. 1 >
ARTICLE | January 1975

Human Subretinal Fluid: Title and subTitle BreakIts Cellular and Subcellular Components FREE

Lynette Feeney, PhD; Robert P. Burns, MD; Robert M. Mixon, MA
[+] Author Affiliations

Submitted for publication July 6, 1973.

Reprint requests to 3181 SW Sam Jackson Park Rd, Portland, OR 97201 (Dr. Feeney).


Arch Ophthalmol. 1975;93(1):62-69. doi:10.1001/archopht.1975.01010020066012
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References
Comments

A light and electron microscopical study of subretinal fluid removed at surgery for rhegmatogenous retinal detachment showed a heterogeneity of cell types originating from the neural retina, pigment epithelium, and wandering cells of the blood. Subcellular organelles sedimenting in the centrifuged pellets could be identified as to cell of origin, health of the parent cell, and time since cell rupture. Acellular specimens were typical of angiomatous detachments or long-standing rhegmatogenous detachments. Because various mechanisms of cellular pathophysiology contribute to the destructive and reparative processes during retinal detachment, the cytologic analysis of subretinal fluid becomes a useful tool in understanding the biological processes that affect visual recovery or impairment after successful retinal detachment surgery.

REFERENCES

1 +
Zimmerman LE, Eastham AB:  Acid mucopolysaccharide in the retinal pigment epithelium and visual cell layer of the developing mouse . Am J Ophthalmol 47:488-498, 1959;.
2 +
Smith JL, Douty E:  Electrophoresis of subretinal fluid . Arch Ophthalmol 64:114-119, 1960;.
3 +
Heath H, Beck TC, Foulds WS:  Chemical composition of subretinal fluid . Br J Ophthalmol 46:385-396, 1962;.
4 +
Weber JC, Wilson FM:  Biochemical studies of subretinal fluid: II. Total protein and albumin of subretinal fluid and blood serum in patients with retinal detachment . Arch Ophthalmol- 69:363-369, 1963;.
5 +
Chignell AH, Carruthers M, Rahi AHS:  Clinical, biochemical, and immunoelectrophoretic study of subretinal fluid . Br J Ophthalmol 55:525-532, 1971;.
6 +
Weber JC, Wilson FM:  Biochemical studies of subretinal fluid: III. Ascorbic acid of subretinal fluid in patients with retinal detachment . Arch Ophthalmol 71:556-557, 1964;.
7 +
Lam KW, Constable IJ, Schepens CL:  Subretinal fluid: Isoenzymes and cytologic studies . Invest Ophthalmol 11:1037-1043, 1972;.
8 +
Kaufman PL, Podos SM:  Subretinal fluid butrylcholinesterase: Source of the enzyme and factors affecting its concentration in subretinal fluid from primary rhegmatogenous retinal detachments . Am J Ophthalmol 75:627-636, 1973;.
9 +
Laszezyk WA:  Trials of differentiation of retinal detachment on the basis of cytological pictures of the subretinal fluid . Klin Oczna 39:227-230, 1969;.
10 +
Machemer R:  Experimental detachment in the owl monkey: II. Histology of retina and pigment epithelium . Am J Ophthalmol 66:396-410, 1968;.
11 +
Kroll AJ, Machemer R:  Experimental detachment in the owl monkey: III. Electron microscopy of retina and pigment epithelium . Am J Ophthalmol 66:410-427, 1968;.
12 +
Feeney L, Wissig SL:  A biochemical and radioautographic analysis of protein secretion by thyroid lobes incubated in vitro . J Cell Biol 53:510-522, 1972;.
13 +
Snodgress AB, et al:  Conventional histopathologic staining methods compatible with Eponembedded, osmicated tissue . Lab Invest 26:329-337, 1972;.
14 +
Fawcett DW: An Atlas of Fine Structure-The Cell, Its Organelles and Inclusions . Philadelphia, WB Saunders Co, 1966;.
15 +
Feeney L:  The Interphotoreceptor Space: II. Histochemistry of the Matrix . Dev Biol 32:115-128, 1973;.
16 +
Wallow IHL, Tso MOM:  Repair after Xenon arc photocoagulation: An electron microscopic study of the evolution of retinal lesions in rhesus monkeys . Am J Ophthalmol 75:957-972, 1973;.
17 +
Feeney L, Grieshaber JA, Hogan MJ:  Studies on human ocular pigment , in Rohen JW (ed): The Structure of the Eye . Stuttgart, Germany, Schattauer Verlag, 1965;, pp 535-548.

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1 +
Zimmerman LE, Eastham AB:  Acid mucopolysaccharide in the retinal pigment epithelium and visual cell layer of the developing mouse . Am J Ophthalmol 47:488-498, 1959;.
2 +
Smith JL, Douty E:  Electrophoresis of subretinal fluid . Arch Ophthalmol 64:114-119, 1960;.
3 +
Heath H, Beck TC, Foulds WS:  Chemical composition of subretinal fluid . Br J Ophthalmol 46:385-396, 1962;.
4 +
Weber JC, Wilson FM:  Biochemical studies of subretinal fluid: II. Total protein and albumin of subretinal fluid and blood serum in patients with retinal detachment . Arch Ophthalmol- 69:363-369, 1963;.
5 +
Chignell AH, Carruthers M, Rahi AHS:  Clinical, biochemical, and immunoelectrophoretic study of subretinal fluid . Br J Ophthalmol 55:525-532, 1971;.
6 +
Weber JC, Wilson FM:  Biochemical studies of subretinal fluid: III. Ascorbic acid of subretinal fluid in patients with retinal detachment . Arch Ophthalmol 71:556-557, 1964;.
7 +
Lam KW, Constable IJ, Schepens CL:  Subretinal fluid: Isoenzymes and cytologic studies . Invest Ophthalmol 11:1037-1043, 1972;.
8 +
Kaufman PL, Podos SM:  Subretinal fluid butrylcholinesterase: Source of the enzyme and factors affecting its concentration in subretinal fluid from primary rhegmatogenous retinal detachments . Am J Ophthalmol 75:627-636, 1973;.
9 +
Laszezyk WA:  Trials of differentiation of retinal detachment on the basis of cytological pictures of the subretinal fluid . Klin Oczna 39:227-230, 1969;.
10 +
Machemer R:  Experimental detachment in the owl monkey: II. Histology of retina and pigment epithelium . Am J Ophthalmol 66:396-410, 1968;.
11 +
Kroll AJ, Machemer R:  Experimental detachment in the owl monkey: III. Electron microscopy of retina and pigment epithelium . Am J Ophthalmol 66:410-427, 1968;.
12 +
Feeney L, Wissig SL:  A biochemical and radioautographic analysis of protein secretion by thyroid lobes incubated in vitro . J Cell Biol 53:510-522, 1972;.
13 +
Snodgress AB, et al:  Conventional histopathologic staining methods compatible with Eponembedded, osmicated tissue . Lab Invest 26:329-337, 1972;.
14 +
Fawcett DW: An Atlas of Fine Structure-The Cell, Its Organelles and Inclusions . Philadelphia, WB Saunders Co, 1966;.
15 +
Feeney L:  The Interphotoreceptor Space: II. Histochemistry of the Matrix . Dev Biol 32:115-128, 1973;.
16 +
Wallow IHL, Tso MOM:  Repair after Xenon arc photocoagulation: An electron microscopic study of the evolution of retinal lesions in rhesus monkeys . Am J Ophthalmol 75:957-972, 1973;.
17 +
Feeney L, Grieshaber JA, Hogan MJ:  Studies on human ocular pigment , in Rohen JW (ed): The Structure of the Eye . Stuttgart, Germany, Schattauer Verlag, 1965;, pp 535-548.

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