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January 1976, Vol 94, No. 1 >
ARTICLE | January 1976

Herpesvirus hominis Encephalitis and Retinitis FREE

Anita Hendrickson, PhD; Cheng Mei Shaw, MD; Edward B. McLean, MD; Don S. Minckler, MD
[+] Author Affiliations

Submitted for publication March 14, 1974.

The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

Reprint requests to Editorial Office, Armed Forces Institute of Pathology, Washington, DC 20306.


Arch Ophthalmol. 1976;94(1):89-95. doi:10.1001/archopht.1976.03910030039011
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• A previously healthy 44-year-old man died three weeks after the simultaneous onset of encephalitis and retinitis. Fundus changes were bilateral and included papillitis, rapidly progressive central retinal vein obstruction, and massive exudative retinal detachment. A 16-fold rise in herpesvirus hominis antibodies occurred between the 10th and 20th days of illness. At autopsy, the brain showed changes characteristic of herpetic encephalitis, and cultures of the brain yielded Herpesvirus hominis type I. Intranuclear inclusion bodies typical of those produced by Herpesvirus were found by light microscopy in brain, optic nerves, retina, and choroid. Herpesvirus particles were found by electron microscopy in brain, optic nerve, and retina.

REFERENCES

1 +
Nahmias AJ:  Infections caused by herpes virus hominis , in Hoeprich PD (ed): Infectious Diseases . Hagerstown, Md, Harper & Row, 1972;.
2 +
Johnson RT, Olson LC, Buescher EL:  Herpes simplex virus infections of the nervous system: Problems in laboratory diagnosis . Arch Neurol 18:260-264, 1968;.
3 +
Cibis A, Burde RM:  Herpes simplex virusinduced congenital cataracts . Arch Ophthalmol 85:220-223, 1971;.
4 +
Florman AL, Mindlin RL:  Generalized herpes simplex in an 11-day-old premature infant . Am J Dis Child 83:481-486, 1952;.
5 +
Golden B, Bell WE, McKee AP:  Disseminated herpes simplex with encephalitis in a neonate . JAMA 209:1219-1221, 1969;.
6 +
Hagler WS, Walters PV, Nahmias AJ:  Ocular involvement in neonatal herpes simplex virus infection . Arch Ophthalmol 82:169-176, 1969;.
7 +
Cogan DG, Kuwabara T, Young GF, et al:  Herpes simplex retinopathy in an infant . Arch Ophthalmol 72:641-645, 1964;.
8 +
Pavan-Langston D, Brockhurst RJ:  Herpes simplex panuveitis . Arch Ophthalmol 81:783-787, 1969;.
9 +
Nahmias A, Dowdle W:  Antigenic and biological differences in herpes virus hominis . Progr Med Virol 10:133-134, 1968;.
10 +
Morgan C, Rose HM, Mednis B:  Electron microscopy of herpes simplex virus: I. Entry . J Virol 2:507-616, 1968;.
11 +
Miller JK, Hesser F, Tomkins VN:  Herpes simplex encephalitis: Report of 20 cases . Ann Intern Med 64:92-102, 1966;.
12 +
Johnson KP, Rosenthal MS, Lerner PI:  Herpes simplex encephalitis: Five virologically proven cases . Arch Neurol 27:103-108, 1972;.
13 +
Smith ME:  Retinal involvement in adult cytomegalic inclusion disease . Arch Ophthalmol 72:44-49, 1964;.
14 +
Font RL, Jenis EH, Tuck KD:  Measles maculopathy associated with subacute sclerosing panencephalitis . Arch Pathol 96:168-174, 1973;.
15 +
Witmer R, Iwamoto T:  Electron microscope observation of herpes-like particles in the iris . Arch Ophthalmol 79:331-337, 1968;.
16 +
Tso MOM, Fine BS, Zimmerman LE:  Photic maculopathy produced by the indirect ophthalmoscope . Am J Ophthalmol 73:686-699, 1972;.
17 +
Tso MOM:  Photic maculopathy in rhesus monkey . Invest Ophthalmol 12:17-34, 1973;.
18 +
Pettit TH, Kimura SJ, Uchida Y, et al:  Herpes simplex uveitis: An experimental study with the fluorescein labeled antibody technique . Invest Opthalmol 4:349-357, 1965;.
19 +
Monjan AA, Silverstein AM, Cole GA:  Lymphocytic choriomeningitis virus-induced retinopathy in newborn rats . Invest Ophthalmol 11:850-856, 1972;.
20 +
Hashida Y, Yunis EJ:  Re-examination of encephalitic brains known to contain intranuclear inclusion bodies . J Clin Pathol 53:537-543, 1970;.
21 +
Hartford CG, Wellinghoff W, Weinstein RA:  Isolation of herpes simplex virus from the cerebrospinal fluid in viral meningitis . Neurology 25:198-200, 1975;.

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1 +
Nahmias AJ:  Infections caused by herpes virus hominis , in Hoeprich PD (ed): Infectious Diseases . Hagerstown, Md, Harper & Row, 1972;.
2 +
Johnson RT, Olson LC, Buescher EL:  Herpes simplex virus infections of the nervous system: Problems in laboratory diagnosis . Arch Neurol 18:260-264, 1968;.
3 +
Cibis A, Burde RM:  Herpes simplex virusinduced congenital cataracts . Arch Ophthalmol 85:220-223, 1971;.
4 +
Florman AL, Mindlin RL:  Generalized herpes simplex in an 11-day-old premature infant . Am J Dis Child 83:481-486, 1952;.
5 +
Golden B, Bell WE, McKee AP:  Disseminated herpes simplex with encephalitis in a neonate . JAMA 209:1219-1221, 1969;.
6 +
Hagler WS, Walters PV, Nahmias AJ:  Ocular involvement in neonatal herpes simplex virus infection . Arch Ophthalmol 82:169-176, 1969;.
7 +
Cogan DG, Kuwabara T, Young GF, et al:  Herpes simplex retinopathy in an infant . Arch Ophthalmol 72:641-645, 1964;.
8 +
Pavan-Langston D, Brockhurst RJ:  Herpes simplex panuveitis . Arch Ophthalmol 81:783-787, 1969;.
9 +
Nahmias A, Dowdle W:  Antigenic and biological differences in herpes virus hominis . Progr Med Virol 10:133-134, 1968;.
10 +
Morgan C, Rose HM, Mednis B:  Electron microscopy of herpes simplex virus: I. Entry . J Virol 2:507-616, 1968;.
11 +
Miller JK, Hesser F, Tomkins VN:  Herpes simplex encephalitis: Report of 20 cases . Ann Intern Med 64:92-102, 1966;.
12 +
Johnson KP, Rosenthal MS, Lerner PI:  Herpes simplex encephalitis: Five virologically proven cases . Arch Neurol 27:103-108, 1972;.
13 +
Smith ME:  Retinal involvement in adult cytomegalic inclusion disease . Arch Ophthalmol 72:44-49, 1964;.
14 +
Font RL, Jenis EH, Tuck KD:  Measles maculopathy associated with subacute sclerosing panencephalitis . Arch Pathol 96:168-174, 1973;.
15 +
Witmer R, Iwamoto T:  Electron microscope observation of herpes-like particles in the iris . Arch Ophthalmol 79:331-337, 1968;.
16 +
Tso MOM, Fine BS, Zimmerman LE:  Photic maculopathy produced by the indirect ophthalmoscope . Am J Ophthalmol 73:686-699, 1972;.
17 +
Tso MOM:  Photic maculopathy in rhesus monkey . Invest Ophthalmol 12:17-34, 1973;.
18 +
Pettit TH, Kimura SJ, Uchida Y, et al:  Herpes simplex uveitis: An experimental study with the fluorescein labeled antibody technique . Invest Opthalmol 4:349-357, 1965;.
19 +
Monjan AA, Silverstein AM, Cole GA:  Lymphocytic choriomeningitis virus-induced retinopathy in newborn rats . Invest Ophthalmol 11:850-856, 1972;.
20 +
Hashida Y, Yunis EJ:  Re-examination of encephalitic brains known to contain intranuclear inclusion bodies . J Clin Pathol 53:537-543, 1970;.
21 +
Hartford CG, Wellinghoff W, Weinstein RA:  Isolation of herpes simplex virus from the cerebrospinal fluid in viral meningitis . Neurology 25:198-200, 1975;.

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