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Herpes Simplex Virus Types 1 and 2: Title and subTitle BreakTherapeutic Response to Antiviral Drugs FREE

Richard D. North, MD; Deborah Pavan-Langston, MD
[+] Author Affiliations

Accepted for publication Nov 19, 1975.

Read before the Association for Research in Vision and Ophthalmology, Sarasota, Fla, April 30, 1975.

Reprint requests to Eye Research Institute of Retina Foundation, Boston, MA 02114 (Dr Pavan-Langston).


Arch Ophthalmol. 1976;94(6):1019-1021. doi:10.1001/archopht.1976.03910030517015
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• In vitro studies have demonstrated a relative resistance of herpes simplex virus type 2 to antiviral therapy when compared with herpes simplex virus type 1. The in vivo studies, however, show an excellent therapeutic response to both antiviral drugs in experimentally induced viral keratoconjunctivitis.

REFERENCES

Hagler WS, Walters PV, Nahmias AM:  Ocular involvement in neonatal herpes simplex virus infection . Arch Ophthalmol 82:169-172, 1969;.
Taffli GA, Nahmias AJ:  Neonatal herpetic infection . Am J Dis Child 118:909-914, 1969;.
Oh JO, Kimura SJ, Ostler, HB:  Acute ocular infection by type 2 herpes simplex virus in adults: Report of two cases . Arch Ophthalmol 93:1127-1129, 1975;.
Oh JO, Stevens TR:  Comparison of types 1 and 2 herpes virus hominis infection of rabbit eyes: 1. Clinical manifestations . Arch Ophthalmol 90:473-476, 1973;.
Nahmias AJ, Dowdle WR:  Antigenic and biologic differences in herpes virus hominis . Prog Med Virol 10:110-112, 1968;.
Lowry SP, Melnick JL, Rawls WE:  Investigation of plaque formation in chick embryo cells as a biological marker for distinguishing herpes virus type 2 from type 1 . J Gen Virol 10:1-9, 1971;.
Pavan-Langston D, Dohlman CH:  A double blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis . Am J Ophthalmol 74:81-88, 1972;.
Pavan-Langston D:  Clinical evaluation of Ara-A and IDU in the treatment of ocular herpes simplex . Am J Ophthalmol 80:495-502, 1975;.
Pavan-Langston D, Langston RHS, Geary PA:  Prophylaxis and therapy of experimental ocular herpes simplex . Arch Ophthalmol 92:417-421, 1974;.

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Hagler WS, Walters PV, Nahmias AM:  Ocular involvement in neonatal herpes simplex virus infection . Arch Ophthalmol 82:169-172, 1969;.
Taffli GA, Nahmias AJ:  Neonatal herpetic infection . Am J Dis Child 118:909-914, 1969;.
Oh JO, Kimura SJ, Ostler, HB:  Acute ocular infection by type 2 herpes simplex virus in adults: Report of two cases . Arch Ophthalmol 93:1127-1129, 1975;.
Oh JO, Stevens TR:  Comparison of types 1 and 2 herpes virus hominis infection of rabbit eyes: 1. Clinical manifestations . Arch Ophthalmol 90:473-476, 1973;.
Nahmias AJ, Dowdle WR:  Antigenic and biologic differences in herpes virus hominis . Prog Med Virol 10:110-112, 1968;.
Lowry SP, Melnick JL, Rawls WE:  Investigation of plaque formation in chick embryo cells as a biological marker for distinguishing herpes virus type 2 from type 1 . J Gen Virol 10:1-9, 1971;.
Pavan-Langston D, Dohlman CH:  A double blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis . Am J Ophthalmol 74:81-88, 1972;.
Pavan-Langston D:  Clinical evaluation of Ara-A and IDU in the treatment of ocular herpes simplex . Am J Ophthalmol 80:495-502, 1975;.
Pavan-Langston D, Langston RHS, Geary PA:  Prophylaxis and therapy of experimental ocular herpes simplex . Arch Ophthalmol 92:417-421, 1974;.

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