0
January 1977, Vol 95, No. 1 >
ARTICLE | January 1977

Retrolental Fibroplasia: Title and subTitle BreakII. Pathologic Correlation FREE

Burton J. Kushner, MD; David Essner; Ira J. Cohen; John T. Flynn, MD
[+] Author Affiliations

Accepted for publication July 30, 1976.

Reprint requests to Bascom Palmer Eye Institute, P.O. Box 520875 Biscayne Annex, Miami, FL 33152 (Dr Flynn).


Arch Ophthalmol. 1977;95(1):29-38. doi:10.1001/archopht.1977.04450010031002
Text Size: A A A
Published online
Article
References
Comments

• Retinas of 142 eyes from 71 premature infants on whom autopsies had been done were studied by gross observation and by using PAS-stained whole mount, trypsin-digest, and conventional histological techniques. With these techniques, vascular pathologic condition was correlated with fluorescein angiograms in living infants with acute retrolental fibroplasia. The specific lesions seen in acute phase were a major arteriovenous shunt in the eye, microvascular changes including tufting, and obliteration of capillaries around arteries and veins. Regression occurred by vascular budding from the anterior edge of the shunt. Observations on vascularization in the normal indicated a variability of the level of maturation of the retinal vasculature, only roughly correlated with gestational age.

(Arch Ophthalmol 95:29-38, 1977)

REFERENCES

1 +
Terry TL:  Extreme prematurity and fibroblastic overgrowth of persistent vascular sheath behind each crystalline lens . Am J Ophthalmol 25:203-208, 1942;.
2 +
Ashton N, Ward B, Serpell G:  Role of oxygen in the genesis of retrolental fibroplasia . Br J Ophthalmol 37:513-520, 1953;.
3 +
Ashton N:  Oxygen and the growth and development of retinal vessels . Am J Ophthalmol 62:412-435, 1966;.
4 +
Patz A:  The effect of oxygen on immature retinal vessels . Invest Ophthalmol 4:988-999, 1965;.
5 +
Kalina RE, Forrest GL:  Proliferative retrolental fibroplasia in infant retinal vessels . Am J Ophthalmol 76:811-815, 1973;.
6 +
Flynn JT, O'Grady GE, Herrara J, et al: Retrolental fibroplasia: I. Clinical observations. Arch Ophthalmol, to be published.
7 +
Kuwabara T, Cogan D:  Studies of retinal vascular patterns: I. Normal architecture . Arch Ophthalmol 64:904-911, 1960;.
8 +
Cogan D:  Development and senescence of the human retinal vasculature . Trans Ophthalmol Soc UK 83:465-489, 1963;.
9 +
Engerman RL, Buesseler JA, Meyer RK:  Periodic acid-Schiff staining of retinal whole mounts . Arch Ophthalmol 68:62-65, 1962;.
10 +
Engerman RL, Bloodworth JMB:  Experimental diabetic retinopathy in dogs . Arch Ophthalmol 73:205-210, 1965;.
11 +
Potter EL: Pathology of the Fetus and Infant , ed 2. Chicago, Yearbook Medical Publishers, 1961;, pp 11-12.
12 +
Warley MA, Gardner D:  Respiratory distress syndrome of the newborn: Principles of treatment . Arch Dis Child 37:455-465, 1962;.
13 +
Engerman RL, Meyer RK:  Development of retinal vasculature in rats . Am J Ophthalmol 60:628-641, 1965;.
14 +
Foos RY, Kopelow SM:  Development of retinal vasculature in perinatal infants . Survey Ophthalmol 18:117-127, 1973;.
15 +
Ashton N:  The mode of development of the retinal vessels in man , in The William Mac-Kenzie Centenary Symposium on the Ocular Circulation in Health and Disease . St Louis, CV Mosby Co, 1969;, pp 7-17.
16 +
Salzmann M: The Anatomy and Histology of the Human Eyeball in the Normal State: Its Development and Senescence . Chicago, University of Chicago Press, 1912;, Plate V.
17 +
Mann I: The Development of the Human Eye , ed. 3. London, British Medical Association, 1964;, p 229.
18 +
Spalter HF, Bruce GM:  Ocular changes in pulmonary insufficiency . Trans Am Acad Ophthalmol Otolaryngol 68:661-676, 1964;.
19 +
Ashton N: Oxygen and the Growth and Development of Retinal Vessel in Vascular Complication of Diabetes Mellitus , Kimura SJ, Caygill WN (eds). St Louis, CV Mosby Co, 1967;, pp 1-71.
20 +
Foos RY:  Acute retrolental fibroplasia . Graefes Arch Ophthalmol 195:87-100, 1975;.
21 +
Campbell FW:  The influence of a low atmospheric pressure on the development of the retinal vessels in the rat . Trans Ophthalmol Soc UK 71:287-300, 1951;.
22 +
Michaelson IC:  The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal diseases . Trans Ophthalmol Soc UK 68:137-180, 1948;.
23 +
Bousquet FP, Laupus WE:  Studies on the pathogenesis of retrolental fibroplasia . Am J Ophthalmol 35:64-68, 1952;.
24 +
Kalina RE:  Ophthalmic examination of children of low birth weights . Am J Ophthalmol 67:134-136, 1969;.
25 +
Patz A:  Retrolental fibroplasia . Survey Ophthalmol 14:1-29, 1969;.
26 +
Bruckner HL:  Retrolental fibroplasia associated with intra-uterine anoxia . Arch Ophthalmol 80:504-505, 1968;.
27 +
Kalina RE, Hodson WA, Morgan BC:  Retrolental fibroplasia in a cyanotic infant . Pediatrics 50:765-768, 1972;.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Terry TL:  Extreme prematurity and fibroblastic overgrowth of persistent vascular sheath behind each crystalline lens . Am J Ophthalmol 25:203-208, 1942;.
2 +
Ashton N, Ward B, Serpell G:  Role of oxygen in the genesis of retrolental fibroplasia . Br J Ophthalmol 37:513-520, 1953;.
3 +
Ashton N:  Oxygen and the growth and development of retinal vessels . Am J Ophthalmol 62:412-435, 1966;.
4 +
Patz A:  The effect of oxygen on immature retinal vessels . Invest Ophthalmol 4:988-999, 1965;.
5 +
Kalina RE, Forrest GL:  Proliferative retrolental fibroplasia in infant retinal vessels . Am J Ophthalmol 76:811-815, 1973;.
6 +
Flynn JT, O'Grady GE, Herrara J, et al: Retrolental fibroplasia: I. Clinical observations. Arch Ophthalmol, to be published.
7 +
Kuwabara T, Cogan D:  Studies of retinal vascular patterns: I. Normal architecture . Arch Ophthalmol 64:904-911, 1960;.
8 +
Cogan D:  Development and senescence of the human retinal vasculature . Trans Ophthalmol Soc UK 83:465-489, 1963;.
9 +
Engerman RL, Buesseler JA, Meyer RK:  Periodic acid-Schiff staining of retinal whole mounts . Arch Ophthalmol 68:62-65, 1962;.
10 +
Engerman RL, Bloodworth JMB:  Experimental diabetic retinopathy in dogs . Arch Ophthalmol 73:205-210, 1965;.
11 +
Potter EL: Pathology of the Fetus and Infant , ed 2. Chicago, Yearbook Medical Publishers, 1961;, pp 11-12.
12 +
Warley MA, Gardner D:  Respiratory distress syndrome of the newborn: Principles of treatment . Arch Dis Child 37:455-465, 1962;.
13 +
Engerman RL, Meyer RK:  Development of retinal vasculature in rats . Am J Ophthalmol 60:628-641, 1965;.
14 +
Foos RY, Kopelow SM:  Development of retinal vasculature in perinatal infants . Survey Ophthalmol 18:117-127, 1973;.
15 +
Ashton N:  The mode of development of the retinal vessels in man , in The William Mac-Kenzie Centenary Symposium on the Ocular Circulation in Health and Disease . St Louis, CV Mosby Co, 1969;, pp 7-17.
16 +
Salzmann M: The Anatomy and Histology of the Human Eyeball in the Normal State: Its Development and Senescence . Chicago, University of Chicago Press, 1912;, Plate V.
17 +
Mann I: The Development of the Human Eye , ed. 3. London, British Medical Association, 1964;, p 229.
18 +
Spalter HF, Bruce GM:  Ocular changes in pulmonary insufficiency . Trans Am Acad Ophthalmol Otolaryngol 68:661-676, 1964;.
19 +
Ashton N: Oxygen and the Growth and Development of Retinal Vessel in Vascular Complication of Diabetes Mellitus , Kimura SJ, Caygill WN (eds). St Louis, CV Mosby Co, 1967;, pp 1-71.
20 +
Foos RY:  Acute retrolental fibroplasia . Graefes Arch Ophthalmol 195:87-100, 1975;.
21 +
Campbell FW:  The influence of a low atmospheric pressure on the development of the retinal vessels in the rat . Trans Ophthalmol Soc UK 71:287-300, 1951;.
22 +
Michaelson IC:  The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal diseases . Trans Ophthalmol Soc UK 68:137-180, 1948;.
23 +
Bousquet FP, Laupus WE:  Studies on the pathogenesis of retrolental fibroplasia . Am J Ophthalmol 35:64-68, 1952;.
24 +
Kalina RE:  Ophthalmic examination of children of low birth weights . Am J Ophthalmol 67:134-136, 1969;.
25 +
Patz A:  Retrolental fibroplasia . Survey Ophthalmol 14:1-29, 1969;.
26 +
Bruckner HL:  Retrolental fibroplasia associated with intra-uterine anoxia . Arch Ophthalmol 80:504-505, 1968;.
27 +
Kalina RE, Hodson WA, Morgan BC:  Retrolental fibroplasia in a cyanotic infant . Pediatrics 50:765-768, 1972;.

Correspondence

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems