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December 1981, Vol 99, No. 12 >
ARTICLE | December 1981

Endothelial Damage After Anterior Radial Keratotomy: Title and subTitle BreakAn Electron Microscopic Study of Rabbit Cornea FREE

Tatsuo Yamaguchi, MD; Frank M. Polack, MD; John Valenti; Herbert E. Kaufman, MD
[+] Author Affiliations

Accepted for publication Feb 13, 1981.

Reprint requests to the LSU Eye Center, 136 S Roman St, New Orleans, LA 70112 (Dr Yamaguchi).


Arch Ophthalmol. 1981;99(12):2151-2158. doi:10.1001/archopht.1981.03930021027009
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References
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• Anterior radial keratotomy was performed on the left eyes of 21 rabbits. Specimens were taken for electron microscopic examination at intervals during a three-month period. The corneas were acutely inflamed for three days after surgery. Some endothelial cells beneath the incisions were damaged, and distended intercellular spaces were seen. Deeper incisions seemed to produce more severe damage. With increasing time after surgery, some of the damaged endothelial cells seemed to be recovering, while others in the areas between the incisions and in the center of the cornea were degenerating. Three months after surgery, the endothelium had recovered, but some of the peripheral intercellular spaces still were distended. These findings may be the result of continuous blinking in combination with the structural weakness of the cornea, rather than a result of chronic postsurgical inflammation.

REFERENCES

1 +
Shibata H:  Experimental research of operative methods for astigmatism . Nippon Univ Med J 1954;;13:1760-1772.
2 +
Sato T, Shibata H, Akiyama K:  Anterior-posterior incision of the cornea for myopia . Acta Soc Ophthalmol Jpn 1952;;56:1137-1139.
3 +
Funahashi M, Yoshida M, Kanai A, et al:  A case of bullous keratopathy after anteroposterior incision of the cornea for myopia . Folia Ophthalmol 1973;;24:19-28.
4 +
Kanai A, Yamaguchi T, Yajima Y, et al:  The fine structure of bullous keratopathy after anteroposterior incision of the cornea for myopia . Folia Ophthalmol 1979;;30:841-849.
5 +
Yamaguchi T, Kanai A, Kaufman HE, et al: A clinical and histopathological study of bullous keratopathy after anterior-posterior incisions of the cornea for myopia. Read before the southern section meeting of the Association for Research in Vision and Ophthalmology, New Orleans, Sept 19, 1980.
6 +
Fyodorov SN, Durnev VV:  Operation of dosaged dissection of corneal circular ligament in case of myopia of mild degree . Ann Ophthalmol 1979;;11:1885-1890.
7 +
Sato T:  Experimental study on surgical correction of astigmatism . Juntendo Med J 1943;;589:37-39.
8 +
Sato T:  Posterior incision of cornea: Surgical treatment for conical cornea and astigmatism . Am J Ophthalmol 1950;;33:943-948.
9 +
Sato T:  Posterior half-incision of cornea for astigmatism: Operative procedures and results of the improved tangent method . Am J Ophthalmol 1953;;36:462-466.
10 +
Van Horn DL, Sendele DD, Seideman S, et al:  Regenerative capacity of the corneal endothelium in rabbit and cat . Invest Ophthalmol Vis Sci 1977;;16:597-613.
11 +
Kaufman HE, Capella JA, Robbins JE:  The human corneal endothelium . Am J Ophthalmol 1966;;61:835-841.
12 +
Bourne WM, Kaufman HE:  Specular microscopy of human corneal endothelium in vivo . Am J Ophthalmol 1976;;81:319-323.
13 +
Laing RA, Sandstrom MM, Berropsi AR, et al:  Changes in the corneal endothelium as a function of age . Exp Eye Res 1976;;22:587-594.
14 +
Laule A, Cable MK, Hoffman CE, et al:  Endothelial cell population changes of human cornea during life . Arch Ophthalmol 1978;;96:2031-2035.
15 +
Sturrock GD, Sherrard ED, Rice NSC:  Specular microscopy of the corneal endothelium . Br J Ophthalmol 1978;;62:809-814.
16 +
Bourne WM, Kaufman HE:  The endothelium of clear corneal transplants . Arch Ophthalmol 1976;;94:1730-1732.
17 +
Bourne WM, O'Fallon WM:  Endothelial cell loss during penetrating keratoplasty . Am J Ophthalmol 1978;;85:760-766.
18 +
Rao GN, Shaw EL, Arthur E, et al:  Morphological appearance of the healing corneal endothelium . Arch Ophthalmol 1978;;96:2027-2030.

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1 +
Shibata H:  Experimental research of operative methods for astigmatism . Nippon Univ Med J 1954;;13:1760-1772.
2 +
Sato T, Shibata H, Akiyama K:  Anterior-posterior incision of the cornea for myopia . Acta Soc Ophthalmol Jpn 1952;;56:1137-1139.
3 +
Funahashi M, Yoshida M, Kanai A, et al:  A case of bullous keratopathy after anteroposterior incision of the cornea for myopia . Folia Ophthalmol 1973;;24:19-28.
4 +
Kanai A, Yamaguchi T, Yajima Y, et al:  The fine structure of bullous keratopathy after anteroposterior incision of the cornea for myopia . Folia Ophthalmol 1979;;30:841-849.
5 +
Yamaguchi T, Kanai A, Kaufman HE, et al: A clinical and histopathological study of bullous keratopathy after anterior-posterior incisions of the cornea for myopia. Read before the southern section meeting of the Association for Research in Vision and Ophthalmology, New Orleans, Sept 19, 1980.
6 +
Fyodorov SN, Durnev VV:  Operation of dosaged dissection of corneal circular ligament in case of myopia of mild degree . Ann Ophthalmol 1979;;11:1885-1890.
7 +
Sato T:  Experimental study on surgical correction of astigmatism . Juntendo Med J 1943;;589:37-39.
8 +
Sato T:  Posterior incision of cornea: Surgical treatment for conical cornea and astigmatism . Am J Ophthalmol 1950;;33:943-948.
9 +
Sato T:  Posterior half-incision of cornea for astigmatism: Operative procedures and results of the improved tangent method . Am J Ophthalmol 1953;;36:462-466.
10 +
Van Horn DL, Sendele DD, Seideman S, et al:  Regenerative capacity of the corneal endothelium in rabbit and cat . Invest Ophthalmol Vis Sci 1977;;16:597-613.
11 +
Kaufman HE, Capella JA, Robbins JE:  The human corneal endothelium . Am J Ophthalmol 1966;;61:835-841.
12 +
Bourne WM, Kaufman HE:  Specular microscopy of human corneal endothelium in vivo . Am J Ophthalmol 1976;;81:319-323.
13 +
Laing RA, Sandstrom MM, Berropsi AR, et al:  Changes in the corneal endothelium as a function of age . Exp Eye Res 1976;;22:587-594.
14 +
Laule A, Cable MK, Hoffman CE, et al:  Endothelial cell population changes of human cornea during life . Arch Ophthalmol 1978;;96:2031-2035.
15 +
Sturrock GD, Sherrard ED, Rice NSC:  Specular microscopy of the corneal endothelium . Br J Ophthalmol 1978;;62:809-814.
16 +
Bourne WM, Kaufman HE:  The endothelium of clear corneal transplants . Arch Ophthalmol 1976;;94:1730-1732.
17 +
Bourne WM, O'Fallon WM:  Endothelial cell loss during penetrating keratoplasty . Am J Ophthalmol 1978;;85:760-766.
18 +
Rao GN, Shaw EL, Arthur E, et al:  Morphological appearance of the healing corneal endothelium . Arch Ophthalmol 1978;;96:2027-2030.

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