RT Journal
A1 Alvarado JA, Underwood JL, Murphy CG
T1 HErpes simplex virus in iridocorneal endothelial syndrome-reply
JF Archives of Ophthalmology
JO Archives of Ophthalmology
YR 1995
FD October 1
VO 113
IS 10
SP 1227
OP 1228
DO 10.1001/archopht.1995.01100100014007
UL http://dx.doi.org/10.1001/archopht.1995.01100100014007
AB In reply 
    Drs Hooks and Kupfer suggest that because HSV DNA is found in the corneas of normal persons and of those with chronic nonviral diseases, its presence in ICE specimens is not unexpected. They claim that to establish an etiologic relationship, combined serologic and HSV DNA tests of patients with the ICE syndrome are mandatory. Until then, antiviral treatment proposals are premature.We use the same articles1,2 cited by Drs Hooks and Kupfer to make the following points: (1) the premise that HSV DNA is commonly found in corneal tissues is not supported by that literature; (2) the localization of HSV DNA intraocularly, together with its prevalence in corneas of patients with the ICE syndrome, is significant and supports a role for HSV in the ICE syndrome; and (3) serologic tests do not provide information additional to that yielded by HSV DNA assays in establishing an etiologic relationship.