TY  - JOUR
T1  - PRedictive value of multiple genetic testing for age-related macular degeneration
AU  - Despriet DG, Klaver CW, van Duijn CC, Janssens AW
Y1  - 2007/09/01
N1  - 10.1001/archopht.125.9.1270
JO  - Archives of Ophthalmology
SP  - 1270
EP  - 1271
VL  - 125
IS  - 9
N2  - 
The unraveling of the genetic background of age-related macular degeneration (AMD) is occurring at a tremendously fast pace. Researchers have shown that single nucleotide polymorphisms (SNPs) in the CFH, LOC387715, C2/FB, and HTRA1 genes are highly associated with AMD1- 10 and have estimated that they explain more than 50% of all cases.2,4,7,10 These genetic discoveries are a major breakthrough for understanding the pathogenesis of the disease, but whether they can be used to improve the prediction of end-stage AMD in individuals at risk is still open to question.11 This requires that testing of multiple SNPs, or genetic profiling, be a better predictor than classic risk factors.

SN  - 0003-9950
M3  - doi: 10.1001/archopht.125.9.1270
UR  - http://dx.doi.org/10.1001/archopht.125.9.1270
ER  -