TY  - JOUR
T1  - Blockage of axonal transport in optic nerve induced by elevation of intraocular pressure: Effect of arterial hypertension induced by angiotensin i
AU  - Sossi N, Anderson DR
Y1  - 1983/01/01
N1  - 10.1001/archopht.1983.01040010096017
JO  - Archives of Ophthalmology
SP  - 94
EP  - 97
VL  - 101
IS  - 1
N2  - • Previous studies have shown that elevation of intraocular pressure blocks rapid axonal transport at the lamina cribrosa of the optic nerve. In this study, IOP-induced blockage of axonal transport was greater in cats with elevation of BP induced by angiotensin I than in control animals with normal BP. The fact that cardiovascular factors influenced IOPinduced blockage of axonal transport suggests that it is due to ischemia; if the blockage were a direct mechanical effect of the IOP on the axons, it should be unaffected by BP. The data also suggest that the vasoconstrictive properties of angiotensin I reduced the ability of the vasculature of the optic nerve head to autoregulate when challenged by elevation of IOP.
SN  - 0003-9950
M3  - doi: 10.1001/archopht.1983.01040010096017
UR  - http://dx.doi.org/10.1001/archopht.1983.01040010096017
ER  -