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 Showing 1-20 of 62 Articles
Brief Report 
Fook Chang Lam, MRCP, FRCOphth; Lamis Baydoun, MD; Martin Dirisamer, MD; Jessica Lie, PhD; Isabel Dapena, MD, PhD; Gerrit R. J. Melles, MD, PhD

Importance  This study evaluates the technical feasibility and clinical outcomes of a Descemet membrane endothelial keratoplasty (DMEK) technique that could increase the availability of donor tissue for DMEK.

Objective  To evaluate the clinical outcome of using a semicircular, large-diameter Descemet membrane graft in DMEK (hemi-DMEK), potentially ...

Ophthalmic Images 
Vivian Lee, MD; Benjamin J. Kim, MD
Graphic Jump LocationA woman in her early 70s with a retinal detachment for 3 months underwent repair, when a subretinal, soft mass was identified. Histopathologic analysis demonstrated birefringent crystals consistent with calcium oxalate, an uncommon finding with chronic detachments (hematoxylin-eosin, original magnification ×10 [A]; polarized light, original magnification ×10 [B]). ...
Topics: eye
Comment & Response 
Richard C. Allen, MD, PhD; Ryan J. Wise, MD
To the Editor We read with special interest the article titled “Botulinum Toxin Type A Injection for Lateral Canthal Rhytids: Effect on Tear Film Stability and Tear Production” by Ho et al1 and offer additional support for the mechanism by which botulinum toxin injection may alter the functioning of the ...
Observation 
Hakan Demirci, MD; Joshua S. Grant, MD; Victor M. Elner, MD, PhD
Primary B-cell mucosa-associated lymphoid tissue (MALT) lymphoma of the iris is rare. The largest published series of 14 iris lymphomas included 3 such lymphomas.1 Thus, data concerning the effectiveness of treatment of these tumors are limited. External radiotherapy (the main treatment), resection, and systemic chemotherapy can cause substantial morbidity. Rituximab ...
Original Investigation 
Robert Burgmeier, BS; Rajen U. Desai, MD; Katherine C. Farner, BS; Benjamin Tiano, BS; Ryan Lacey, BS; Nicholas J. Volpe, MD; Marilyn B. Mets, MD
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Children with a history of amblyopia, even if resolved, exhibit impaired visual-auditory integration and perceive speech differently.

Objective  To determine whether a history of amblyopia is associated with abnormal visual-auditory speech integration.

Design, Setting, and Participants  Retrospective observational study at an academic pediatric ophthalmologic ...

Original Investigation 
De-Kuang Hwang, MD, PhD; Catherine Jui-Ling Liu, MD; Cheng-Yun Pu, PhD; Yiing-Jenq Chou, MD, PhD; Pesus Chou, DrPH

Importance  Medication persistence is an important factor for treatment effect in patients with glaucoma. Evaluating risk factors for refill discontinuation might be helpful for improving persistence and preventing blindness in patients with glaucoma.

Objectives  To estimate the persistence rate with topical glaucoma medication 2 years after ...

Surgical Technique 
Atsuhiro Tanikawa, MD; Masayuki Horiguchi, MD
Almost all cataract surgical procedures rely on phacoemulsification, which requires favorable lens visibility. Visibility can be negatively affected by various ocular pathologies including dense vitreous hemorrhage. When the microscope light source reflects off the ocular fundus, the lens is transilluminated. In the presence of dense vitreous hemorrhage, light cannot adequately ...
Ophthalmic Images 
Lucio Zeppa, MD; Luigi Ambrosone, MD; Germano Guerra, MD; Michele Fortunato, MD; Ciro Costagliola, MD
Graphic Jump LocationA microcatheter filled with 1.25 μg of indocyanine green (ICG) diluted in 1 mL of viscoelastic solution was placed into the Schlemm canal (SC) to enlarge the drainage canal; the dye was then injected into the SC. Near-infrared fluorescence real images of aqueous humor outflow structures in in ...
Topics: aqueous humor; eye
Observation 
Christine Y. Chen, PhD; Michael Engelbert, MD; K. Bailey Freund, MD; Carol L. Shields, MD; Gaetano Barile, MD
Laser photocoagulation–induced choroidal neovascularization (CNV) is an uncommon iatrogenic complication following thermal laser treatment for diabetic macular edema and proliferative diabetic retinopathy.1 Disruption of the retinal pigment epithelium–Bruch membrane complex due to intense laser energy presumably leads to the development of CNV.1,2 We report a dramatic case of laser-induced CNV ...
Original Investigation 
Stefano A. Gandolfi, MD; Nicola Ungaro, MD; Maria Grazia Tardini, AO; Stella Ghirardini, AO; Arturo Carta, MD; Paolo Mora, MD

Importance  Prospective long-term analyses of the role of drug-induced mydriasis and laser peripheral iridotomy (LPI) are needed to identify and manage the eyes of patients with pigment dispersion syndrome (PDS) at risk for progressing to ocular hypertension.

Objective  To assess the 10-year incidence of increased intraocular ...

Original Investigation 
Louis R. Pasquale, MD; Aliya Z. Jiwani, MD; Tzukit Zehavi-Dorin, MD; Arow Majd, MD; Douglas J. Rhee, MD; Teresa Chen, MD; Angela Turalba, MD; Lucy Shen, MD; Stacey Brauner, MD; Cynthia Grosskreutz, MD, PhD; Matthew Gardiner, MD; Sherleen Chen, MD; Sheila Borboli-Gerogiannis, MD; Scott H. Greenstein, MD; Kenneth Chang, MD; Robert Ritch, MD; Stephanie Loomis, MPH; Jae H. Kang, ScD; Janey L. Wiggs, MD, PhD; Hani Levkovitch-Verbin, MD, MPA

Importance  Residential (geographic) history and extent of solar exposure may be important risk factors for exfoliation syndrome (XFS) but, to our knowledge, detailed lifetime solar exposure has not been previously evaluated in XFS.

Objective  To assess the relation between residential history, solar exposure, and XFS.

Design, ...

Special Communication 
Michael K. Jensen, MS, RPh; Robert Nahoopii, PharmD, MS; Beth Johnson, RPh
Includes: Supplemental Content

Importance  Quality and safety of eyedrop use for patients treated in a health care setting play a vital role in the delivery of health care.

Objective  To describe the development of a policy and procedural approach to the use of multidose eyedrops in multiple patients, approved ...

Ophthalmic Images 
Bryn M. Burkholder, MD; James P. Dunn, MD
Graphic Jump LocationA 20-year-old healthy patient with a history of corneal perforation from chronic herpetic disease in the left eye presented with decreased vision in the right eye. Wide-field fluorescein angiography showed punctate areas of leakage and multiple lobular serous retinal detachments in the posterior pole of the right eye ...
Observation 
Alison M. Dzwonczyk, MD; Zélia M. Corrêa, MD, PhD; James J. Augsburger, MD; Dwight Kulwin, MD
Although orbital exenteration has been recommended for extensive malignant conjunctival neoplasms, including those invading the palpebral margin, fornices, or caruncle, it has not been demonstrated to improve survival of patients with melanomas greater than 2.0 mm thick.1 We describe a patient with extensive conjunctival melanoma (CM) managed by eye-preserving therapies. ...
Original Investigation 
Shuai-Chun Lin, MD; Sophia Y. Wang, MD; Chungkwon Yoo, MD, PhD; Kuldev Singh, MD; Shan C. Lin, MD

Importance  Evidence suggests that altered iron metabolism may be associated with oxidative damage to several organ systems, including the eye. Supplementary iron consumption is also associated with greater odds of self-reported glaucoma.

Objective  To investigate the association between serum ferritin level and the likelihood of a ...

Original Investigation 
Jeannette Beckman Rehnman; Anders Behndig, MD, PhD; Per Hallberg, PhD; Christina Lindén, MD, PhD

Importance  A reliable tool for quantification of the biomechanical status of the cornea in conjunction with corneal collagen crosslinking (CXL) treatment is needed.

Objective  To quantify the biomechanical effects of CXL in vivo.

Design, Setting, and Participants  A prospective, open, case-control study was conducted at ...

Viewpoint 
Malvina B. Eydelman, MD
The role of the US Food and Drug Administration (FDA) is to protect public health—keeping unsafe medical devices off the market, exposing potentially dangerous devices that carry fraudulent claims to cure or treat disease, and investigating potential and emerging health and safety issues related to medical devices in the United ...
Ophthalmic Images 
Lauren S. Taney, MD; Caroline R. Baumal, MD
Graphic Jump LocationCystic retinal tuft (CRT) is a developmental vitreoretinal abnormality found in 5% of autopsy eyes. Clinical examination reveals a focal, elevated gliotic lesion in the peripheral retina associated with vitreous traction (Figure, A and B). Histopathological analysis demonstrates a dome-shaped area with internal microcysts, glial cell proliferation, outer ...
Research Letter 
Eleonora M. Lad, MD, PhD; Christine M. Hulette, MD; Alan D. Proia, MD, PhD
Primary angiitis of the central nervous system (PACNS), also known as primary vasculitis of the central nervous system, is a rare, poorly understood, and often fatal disorder.1,2 Although the association of PACNS with optic neuropathy has been documented,3- 5 this is the first report to our knowledge of visual loss ...
Observation 
Leonard Goussard Heydenrych, FCOphth (SA), FRCOphth; Colleen Michelle Aldous, PhD; Roy Giles, FCRad (SA); Grant Andre du Plessis, MMED Neurosurg (Stell); Burnet Meyer, MMED Ophth (Stell), FCS (SA)
Distinguishing between a cerebrospinal fluid (CSF) collection of the upper eyelid and an abscess can be challenging, as the following case demonstrates. Each may be preceded by surgical intervention and both could present with pyrexia. Good clinical skills will assist in differentiation, but laboratory tests are required to provide the ...

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