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 Showing 1-20 of 47 Articles
Original Investigation 
Matthew G. Vicinanzo, MD; Gerald McGwin Jr, MS, PhD; Chaitanya Allamneni, BA; John A. Long, MD

Importance  The timing and indications for repair of orbital floor fractures have been controversial. Current practice dictates that fractures involving more than 50% of the orbital floor should be repaired. Early management is initiated in such situations to prevent long-term sequelae of enophthalmos and diplopia. Because fracture ...

Invited Commentary: The Opportunity of Variability; Russell S. Gonnering, MD
Original Investigation 
Jeremy A. Guggenheim, PhD; Cathy Williams, MBBS, PhD, FRCOphth; for the UK Biobank Eye and Vision Consortium
Includes: Supplemental Content

Importance  Visual impairment due to myopia is an important public health issue. A prior analysis of population-based cohorts aged 15 to 22 years recruited from the United Kingdom and Israel suggested myopia and high myopia were approximately 10% more common in first-born compared with later-born children.


Original Investigation  FREE
Juan Wu, MS; Eunyoung Cho, ScD; Walter C. Willett, MD, MPH, DrPH; Srinivas M. Sastry, MD, MPH; Debra A. Schaumberg, ScD, OD, MPH
Includes: Supplemental Content

Importance  Despite strong biological plausibility, evidence from epidemiologic studies and clinical trials on the relations between intakes of lutein and zeaxanthin and age-related macular degeneration (AMD) has been inconsistent. The roles of other carotenoids are less thoroughly investigated.

Objective  To investigate the associations between intakes of ...

Brief Report 
Daniël A. Korevaar, MD; Jérémie F. Cohen, MD, PhD; Maurice W. J. de Ronde, MD; Gianni Virgili, MD; Kay Dickersin, PhD; Patrick M. M. Bossuyt, PhD
Includes: Supplemental Content

Importance  Conference abstracts present information that helps clinicians and researchers to decide whether to attend a presentation. They also provide a source of unpublished research that could potentially be included in systematic reviews. We systematically assessed whether conference abstracts of studies that evaluated the accuracy of a ...

Invited Commentary 
Russell S. Gonnering, MD

The study by Vicinanzo et al1 has important implications for treatment of orbital fractures in particular, but it also uncovers larger issues that extend beyond treatment of this entity. In some respects, these larger problems carry much greater significance not just for ophthalmology but also for all ...

JAMA Ophthalmology Clinical Challenge 
Aristomenis Thanos, MD; Daniel D. Esmaili, MD; Dean Eliott, MD

A healthy white man in his late 70s was referred for evaluation of nerve fiber layer infarcts after experiencing nonprogressive diminished vision in his left eye for 6 weeks. Dilated fundus examination showed a nerve fiber layer infarct inferior to the optic nerve in the right eye, and ...

Research Letter 
Uri Elbaz, MD; Kamiar Mireskandari, MBChB, FRCSEd, FRCOphth, PhD; Caitriona Kirwan, MB, BCh, FRCSI(Ophth); Asim Ali, MD, FRCSC

This case series compares the use of corneal endothelial specular microscopy in children under anesthesia with that in children who are awake.

Original Investigation 
Ann-Cathrine Larsen, MD; Christina M. Dahmcke, MSc; Christina Dahl, PhD; Volkert D. Siersma, PhD; Peter B. Toft, MD, DMSc; Sarah E. Coupland, MBBS, PhD; Jan U. Prause, MD, DMSc; Per Guldberg, PhD; Steffen Heegaard, MD, DMSc

Importance  Large studies investigating clinical presentation and treatment in primary conjunctival melanoma (CM) are rare. Clinicopathological characteristics of BRAF-mutated CM have not been studied thoroughly.

Objectives  To determine the associations of clinicopathological tumor features and treatment with local recurrence, metastasis, and mortality and to determine ...

Invited Commentary: Conjunctival Melanoma Now and in the Future; Dan S. Gombos, MD
Original Investigation 
Feyzahan Ekici, MD; Rebecca Loh, BA; Michael Waisbourd, MD; Yi Sun, MD; Patricia Martinez, MD; Natasha Nayak, MD; Sheryl S. Wizov, COA; Sarah Hegarty, MPhil; Lisa A. Hark, PhD, RD; George L. Spaeth, MD

Importance  To our knowledge, few studies have combined an objective measure of vision-related performance (VRP) and subjective measures of vision-related quality of life (VRQoL) with clinically related visual parameters, particularly in a large, prospective, cohort study setting.

Objective  To examine the relationships between clinical visual assessments ...

Original Investigation 
Xiuqin Wang, MD; Hongmei Yi, PhD; Lina Lu, MM; Linxiu Zhang, PhD; Xiaochen Ma, PhD; Ling Jin, MS; Haiqing Zhang, PhD; Kovin S. Naidoo, OD, MPH; Hasan Minto, DipOpt; Haidong Zou, MD; Scott Rozelle, PhD; Nathan Congdon, MD, MPH
Includes: Supplemental Content

Importance  The number of urban migrants in China is 300 million and is increasing rapidly in response to government policies. Urban migrants have poor access to health care, but little is known about rates of correction of refractive error among migrant children. This is of particular significance ...

Invited Commentary: Impaired Visual Acuity and Spectacle Ownership in Eastern China; Joshua R. Ehrlich, MD, MPH; Nick Kourgialis; David S. Friedman, MD, MPH, PhD
Invited Commentary 
Dan S. Gombos, MD

In this issue of JAMA Ophthalmology, Larsen and colleagues1 performed a retrospective review of primary conjunctival melanomas; the cohort represented a 50-year retrospective assessment of specimens identified in the Eye Pathology Institute at the University of Copenhagen. The authors performed an analysis looking for BRAF mutation ...

Invited Commentary 
Joshua R. Ehrlich, MD, MPH; Nick Kourgialis; David S. Friedman, MD, MPH, PhD

Wang et al1 examined the prevalence of visual impairment and spectacle ownership among urban-dwelling migrant children in eastern China. They found a high rate of visual impairment from refractive error and a low rate of spectacle use. They noted that migrant children were significantly less likely to ...

Anna M. Stagner, MD; Frederick A. Jakobiec, MD, DSc; Mami A. Iwamoto, MD

This case report describes an invasive squamous cell carcinoma arising in the eyelid skin in a seborrheic keratosis.

Original Investigation 
Mary Qiu, MD; Carol L. Shields, MD
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Choroidal nevus is a precursor for uveal melanoma and there are no known risk factors besides white race. Female sex hormones have been hypothesized to play a role in the pathogenesis of uveal melanoma.

Objective  To explore the association between female reproductive factors and choroidal ...

Original Investigation 
Sanna Leinonen, MD; Kaisu Kotaniemi, MD, PhD; Tero Kivelä, MD, PhD; Anna Majander, MD, PhD
Includes: Supplemental Content

Importance  The majority of patients with juvenile idiopathic arthritis–related uveitic glaucoma require surgery to control intraocular pressure. Trabeculectomy with mitomycin C (MMC) is a major treatment option, although both chronic inflammation and young age increase risk of filtration failure. Factors that potentially protect from filtration failure are ...

Original Investigation 
Ahmed Z. Soliman, MD; Chao Xing, PhD; Salma H. Radwan, MD; Xin Gong, MD; V. Vinod Mootha, MD
Includes: Supplemental Content

Importance  The CTG18.1 triplet repeat expansion in TCF4 has recently been found to be a common functional variant contributing significant risk to the development of Fuchs endothelial corneal dystrophy (FECD) in Eurasian populations.

Objectives  To determine the effect of the expanded CTG18.1 allele of TCF4 on ...

Invited Commentary: Genetics of Fuchs Corneal Dystrophy Comes of Age; Olof H. Sundin, PhD
Invited Commentary 
Olof H. Sundin, PhD

Fuchs endothelial corneal dystrophy (FECD) is a degenerative disorder that affects 5% of those older than 40 years and is the leading indication for corneal transplantation. The first sign of FECD is the presence of microscopic refractile granules in the Descemet membrane that increase in number as the ...

JAMA Ophthalmology Clinical Challenge 
Enchun M. Liu, MD; Rithwick Rajagopal, MD, PhD; M. Gilbert Grand, MD

A young man presents with color blindness, vision loss, and a recent history of confusion, short-term memory loss, vomiting, diarrhea, and hair loss. What would you do next?

Research Letter 
Ashvini K. Reddy, MD; Yevgeniy Shildkrot, MD; Steven A. Newman, MD; Jennifer E. Thorne, MD, PhD

This case report describes a T-lymphocyte infiltrate and cellular atypia in a patient with tattoo-associated uveitis.

Original Investigation 
Sang Jun Park, MD, MSc; Soyeon Ahn, PhD; Se Joon Woo, MD, PhD; Kyu Hyung Park, MD, PhD
Includes: Supplemental Content

Importance  Visual impairment (VI) causes a considerable public health burden and substantial deterioration in health-related quality of life (HRQoL). However, the relative effect of VI on HRQoL compared with other chronic health conditions is unknown as is the additive effect of VI with other conditions.

Objective  ...

Invited Commentary: Vision Impairment and Chronic Health Conditions; Jill Elizabeth Keeffe, OAM, PhD

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