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Brief Report 
Shlomit Schaal, MD, PhD; Aleksandr Kagan, MD; Yujuan Wang, MD; Chi-Chao Chan, MD; Henry J. Kaplan, MD

Importance  Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation. We report the clinical history and histopathologic confirmation that EBV can ...

Brief Report 
Philip J. Banerjee, FRCOphth; Aman Chandra, FRCOphth; Paul M. Sullivan, FRCOphth; David G. Charteris, FRCOphth

Importance  Trigeminal nerve lesions at differing levels can result in complete or partial corneal anesthesia and ensuing epithelial breakdown. Disease progression can lead to corneal ulceration, melt, and perforation. To our knowledge, neurotrophic corneal ulceration has not previously been reported after retinal detachment surgery and argon endolaser....

Ophthalmic Images 
Amir A. Azari, MD; Mozhgan Rezaei Kanavi, MD; Ashley M. Lundin, MD; Matthew J. Thompson, MD; Heather D. Potter, MD; Daniel M. Albert, MD
Figure 1. A 77-year-old man presented with corneal neovascularization and haze unresponsive to topical and subconjunctival steroids. Histopathology reveals corneal and conjunctival tissues with atypia of the surface epithelium (cytokeratin AE/AE3 [A]). The corneal stroma is infiltrated with atypical squamoid cells staining positive with cytokeratin AE/AE3 (B and C). All ...
Original Investigation 
Juan Ding, PhD; David A. Sullivan, PhD

Importance  A phase 1 study has reported that dry eye disease is the most common adverse effect of human exposure to the antibody figitumumab, an anticancer drug that prevents insulin-like growth factor 1 (IGF-1) from binding to its receptor. We hypothesized that the mechanism underlying this effect ...

Original Investigation 
William Marshall Guy, MD; Charles N. S. Soparkar, MD, PhD; Eugene L. Alford, MD; James R. Patrinely, MD; Mirwat S. Sami, MD; Robert B. Parke, MD

Importance  Current controversy about the primary treatment of traumatic optic neuropathy (TON) has anchored on final vision following injury, but, to our knowledge, no study has examined the effect of different treatments on regaining and protecting optic nerve reserve or on the outcome of second optic nerve ...

Original Investigation 
Henry D. Jampel, MD, MHS; Sandra D. Cassard, ScD; David S. Friedman, MD, PhD; Nakul S. Shekhawat, MPH; Julia Whiteside-de Vos, MD, MPH; Harry A. Quigley, MD; Emily W. Gower, PhD

Importance  Laser trabeculoplasty (LTP) is routinely used to treat open-angle glaucoma; hence, understanding variations in its use over time and region is important.

Objective  To determine trends over time and the regional variation in the performance of LTP.

Design, Setting, and Participants  Database analysis of ...

Ophthalmic Images 
Jia-Kang Wang, MD; Ting-Yu Shih, MD
Graphic Jump LocationTriamcinolone acetonide (40 mg in 1 mL) was accidentally injected into the optic nerve with a 25-gauge 1-in needle in a 55-year-old woman. Fundus photography of the optic disc showed overlying protruding triamcinolone acetonide suspension (A) and subsequent atrophy 6 months later (B).
Original Investigation 
Joseph Moisseiev, MD; Iris Moroz, MD; Gabriel Katz, MD

Importance  Assessing the effect of ocriplasmin availability on the management of full-thickness macular holes (MHs) is important for vitreoretinal surgeons and their patients. Such an assessment can indicate whether the use of ocriplasmin will bring a paradigm shift in treating MHs or will be just an additional ...

Original Investigation 
Renbing Jia, MD, PhD; Shiqiong Xu, MD; Xiaolin Huang, MD; Xin Song, MD; Hui Pan, MD; Leilei Zhang, MD; Fanglin He, MD; Ming Lin, MD; Shengfang Ge, PhD; Xianqun Fan, MD, PhD
Includes: Supplemental Content

Importance  Low-flow orbital or periorbital venous malformation (OVM) is the most common periorbital vascular lesion that may produce an appearance defect, visual dysfunction, internal hemorrhage, and thrombosis. Intralesional injection of pingyangmycin as a minimally invasive, gentle intervention may have better outcomes in treating low-flow OVMs compared with ...

Original Investigation 
Carol L. Shields, MD; Sruthi Arepalli, BA; Erin B. Lally, MD; Sara E. Lally, MD; Jerry A. Shields, MD

Importance  The management of symptomatic iris stromal cyst is challenging using methods of aspiration with or without adjunctive cryotherapy, intracameral cautery, or photocoagulation. Failed cases often require surgical resection, with risks for epithelial downgrowth, glaucoma, blindness, and loss of the eye.

Objective  To study the safety ...

Original Investigation 
Hossein Nazari, MD; Petros C. Karakousis, MD; Narsing A. Rao, MD

Importance  Mycobacterium tuberculosis is an important cause of posterior uveitis in tuberculosis-endemic regions. Clinical and histopathologic evidence suggests that retinal pigment epithelium (RPE) can harbor M tuberculosis. However, the mechanism of M tuberculosis phagocytosis and its growth in RPE is not clear.

Objective  To investigate ...

Original Investigation 
Ankoor S. Shah, MD, PhD; Sanjay P. Prabhu, MBBS, FRCR; Mohammad Ali A. Sadiq, MD; Iason S. Mantagos, MD; David G. Hunter, MD, PhD; Linda R. Dagi, MD
Includes: Supplemental Content

Importance  Third nerve palsy causes disfiguring, incomitant strabismus with limited options for correction.

Objective  To evaluate the oculomotor outcomes, anatomical changes, and complications associated with adjustable nasal transposition of the split lateral rectus (LR) muscle, a novel technique for managing strabismus associated with third nerve palsy....

Brief Report 
Zhijia Hou, MD; Bobby S. Korn, MD; Jingwen Ding, MD; Dongmei Li, MD

Importance  Extensive epibulbar choristomas associated with microphthalmia have rarely been reported. We report 2 cases and describe our experience in the diagnosis and management of this challenging entity.

Observations  The clinical features, surgical and histopathologic findings, and aesthetic results of surgical treatment were recorded.

Conclusions and ...

Ophthalmic Images 
Kailun Jiang, MD; Seymour Brownstein, MD; Kay Lam, MD; David Chow, MD; W. Bruce Jackson, MD
Graphic Jump LocationA, An 87-year-old woman with bilateral posterior polymorphous amyloid degeneration showing deep corneal stromal punctate/droplike lesions (arrowheads) on right eye retroillumination. B, Histopathological examination disclosed numerous amorphous, deep corneal stromal deposits (hematoxylin-eosin, original magnification ×40). C and D, Congophilic deposits with apple-green birefringence (Congo red, original magnification ×100). ...
Original Investigation 
Evelyn C. O’Neill, MB, BCh, BAO, MD, MRCOphth; Lulu U. Gurria, MD; Surinder S. Pandav, MBBS, MS; Yu Xiang G. Kong, MBBS, PhD; Jessica F. Brennan, BOrth&OphthalSc; Jing Xie, MD, PhD; Michael A. Coote, MBBS, FRANZCO; Jonathan G. Crowston, PhD, FRANZCO

Importance  Glaucoma is a significant health problem for which diagnosis remains suboptimal. Optic disc evaluation, which is fundamental to the diagnosis, is a difficult skill to acquire.

Objectives  To determine the optic disc characteristics that most influence decision making in the assessment of glaucoma likelihood and ...

Original Investigation 
Jae H. Kang, ScD; Stephanie J. Loomis, MPH; Janey L. Wiggs, MD, PhD; Walter C. Willett, MD, DrPH; Louis R. Pasquale, MD

Importance  Effective strategies for primary prevention are lacking for exfoliation glaucoma (EG), which is the most common type of secondary glaucoma.

Objective  To examine the association between B vitamin intake and EG or suspected EG (EG/SEG) risk.

Design, Setting, and Participants  National prospective cohort study ...

Original Investigation 
Robert Ritch, MD; Ben Darbro, MD, PhD; Geeta Menon, MD; Cheryl L. Khanna, MD; Frances Solivan-Timpe, BS; Ben R. Roos, BS; Mansoor Sarfarzi, PhD; Kazuhide Kawase, MD; Tetsuya Yamamoto, MD; Alan L. Robin, MD; Andrew J. Lotery, MD; John H. Fingert, MD, PhD

Importance  Normal-tension glaucoma (NTG) is a common cause of vision loss.

Objective  To investigate the role of TANK binding kinase 1 (TBK1) gene duplications in NTG to gain insights into the causes of glaucoma that occurs at low intraocular pressure (IOP).

Design, Setting, and ...

Brief Report 
Amir A. Azari, MD; Mozhgan R. Kanavi, MD; Mark Lucarelli, MD; Vivian Lee, MD; Ashley M. Lundin, MD; Heather D. Potter, MD; Daniel M. Albert, MD

Importance  To report the clinical and histopathologic findings of ocular adnexal angiolymphoid hyperplasia with eosinophilia, an unusual but often misdiagnosed benign disorder.

Observations  The ophthalmologic findings of angiolymphoid hyperplasia with eosinophilia with ocular adnexal involvement are variable and include eyelid swelling, ptosis, proptosis, and loss of ...

Ophthalmic Images 
Jose M. Caminal, MD, PhD; Daniel E. Maidana, MD; Pablo Carnota, MD; Estefanía Cobos-Martin, MD; Luis Arias, MD, PhD
Graphic Jump LocationA, At presentation, there is a 3.5-mm–diameter sporadic hemangioblastoma, feeding arteriole, draining vein, hemorrhages, and exudation. B, Fluorescein angiogram at presentation. C, Three months after photodynamic therapy (50 J/cm2), there is clearance of hemorrhages. D, Follow-up at 37 months shows clearance of exudation and tumor size reduction.
Original Investigation 
Zia Chaudhuri, MS, FRCS(Glasg); Joseph L. Demer, MD, PhD

Importance  Extraocular muscle strengthening is a common treatment for strabismus. Plication is an alternative procedure for strengthening muscles with less tissue trauma than resection.

Objective  To compare the surgical dose effect of plication with that of resection.

Design, Setting, and Participants  Retrospective comparison of surgical ...

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