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 Showing 1-20 of 77 Articles
Brief Report 
Felipe P. P. Almeida, PhD, MD; Ana Claudia De Lucca, PhD, MD; Ingrid Ursula Scott, MPH, MD; Rodrigo Jorge, PhD, MD; Andre Messias, PhD, MD

Importance  This case report describes a man who developed retinal changes in his right eye associated with brilliant blue G migration into the subretinal space during 2 years of follow-up.

Observation  The patient’s best-corrected visual acuity in the right eye was 20/70 before surgery, and it ...

Ophthalmic Images 
Ehsan Rahimy, MD; James Vander, MD
Graphic Jump LocationA 43-year-old man with a known history of macular telangiectasia type II presented with acute onset of a scalloped-shaped scotoma, which he described as “seeing a seashell” in his right eye. Ophthalmoscopy revealed intraretinal and subretinal macular hemorrhage, and fluorescein angiography demonstrated perifoveal leakage consistent with subretinal neovascularization. ...
Eric K. Chin, MD; David R. P. Almeida, MD, MBA, PhD; Bradley A. Sacher, MD; H. Culver Boldt, MD
Oral sunitinib malate (Sutent) is a tyrosine kinase inhibitor that prevents binding of vascular endothelial growth factor and platelet-derived growth factor to their native receptors.1 It has been approved by the US Food and Drug Administration for the treatment of renal cell carcinoma (RCC) and imatinib mesylate–resistant gastrointestinal stromal tumor. ...
Original Investigation 
Lingmin He, MD; Edward E. Manche, MD
Includes: Supplemental Content

Importance  Wavefront-guided (WFG) and wavefront-optimized (WFO) platforms for refractive surgery are designed for improved visual outcomes. It is unclear which treatment profile is superior for patients undergoing photorefractive keratectomy (PRK).

Objective  To compare the safety, efficacy, predictability, stability, and higher-order aberrations in eyes undergoing WFG and ...

Original Investigation 
Writing Committee for the Cornea Donor Study Research Group
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  The Cornea Donor Study (CDS) showed that donor age is not a factor in survival of most penetrating keratoplasties for endothelial disease. Secondary analyses confirm the importance of surgical indication and presence of glaucoma in outcomes at 10 years.

Objective  To assess the relationship between ...

Brief Report 
Tomoyuki Inoue, MD; Naoyuki Maeda, MD; Xiaodong Zheng, MD; Takashi Suzuki, MD; Daikichi Mitsuyama, MD; Norio Okamoto, MD; Tomoko Miura, MD; Tomiya Mano, MD; Yuichi Ohashi, MD
Includes: Supplemental Content

Importance  Landolt ring–shaped epithelial keratopathy is a newly identified disease with vesicular changes of unknown origin in the epithelial cells.

Observations  Eleven Japanese patients with specific epithelial lesions that resembled a Landolt ring in the corneal epithelium were assessed. The main symptoms of Landolt ring–shaped epithelial ...

Ophthalmic Images 
Sandro Sbordone, MD; Alfonso Savastano, MD; Vito Romano, MD
Graphic Jump LocationPostoperative hypotony presumably allowed ointment to gain entrance into the anterior and posterior chambers (arrowheads) as photographed 4 weeks after phacoemulsification.
Research Letter 
Frederick A. Jakobiec, MD, DSc; Alia Rashid, MBChB; Kyle Lewis, MD
Neurofibromatosis type 1 (NF1), an autosomal dominant syndrome, has major extraocular expressions of bilateral ptosis, diffuse and plexiform neurofibromas, optic nerve gliomas, and dysplasia of the sphenoid bone. With respect to the eyeball, the spectrum of involvement includes enlarged corneal nerves, Lisch iris nodules, dysplasia of the anterior chamber angle ...
Original Investigation 
Richard F. Spaide, MD; James M. Klancnik Jr, MD; Michael J. Cooney, MD

Importance  The retinal vasculature is involved in many ocular diseases that cause visual loss. Although fluorescein angiography is the criterion standard for evaluating the retina vasculature, it has risks of adverse effects and known defects in imaging all the layers of the retinal vasculature. Optical coherence tomography ...

Original Investigation 
Richard F. Spaide, MD; James M. Klancnik Jr, MD; Michael J. Cooney, MD

Importance  Macular telangiectasia type 2 (MacTel 2) is a rare disease in which abnormalities of the retinal vasculature play a key role. The vascular abnormalities are typically evaluated using fluorescein angiography, a modality with known defects in imaging the deeper layers of the retinal vasculature. Angiography based ...

Brief Report 
Brennan Eadie, MD, PhD; Mahyar Etminan, PharmD, MSc; Frederick S. Mikelberg, MD, FRCSC

Importance  Numerous case reports have suggested that the recent use of moxifloxacin may lead to uveitis. This epidemiologic study is, to our knowledge, the first to explore the relationship between oral moxifloxacin hydrochloride use and uveitis.

Observations  We conducted a case-control study within a cohort of ...

Ophthalmic Images 
Ashleigh L. Levison, MD; Andrew P. Schachat, MD
Graphic Jump LocationA 24-year-old woman with lupus and antiphospholipid syndrome presented with sudden vision loss. By clinical examination and fluorescein angiography, she was diagnosed with a central retinal artery occlusion in the left eye. The retinal edema was associated with a macular hole documented on an optical coherence tomography image. ...
Invited Commentary 
Hendrik P. N. Scholl, MD, MA; Syed Mahmood Ali Shah, MBBS
From the first discovery of chloroquine by Hans Andersag at Bayer in 1939 and later development of its hydroxyl and less toxic form hydroxychloroquine (HCQ), these medications have been one of the most abundantly used around the world and have been instrumental in saving countless lives from malaria. Hydroxychloroquine is ...
Research Letter 
Clovis Arcoverde Freitas-Neto, MD; Rogério A. Costa, MD, PhD; Ninani Kombo, MD; Theophilo Freitas, MD; Juliana Lambert Oréfice, MD, PhD; Fernando Oréfice, MD; C. Stephen Foster, MD
The lymphatic system maintains tissue fluid balance and immunity. It also plays an important role in pathologic conditions such as tumor metastasis and inflammation. The anatomists Arnold (in 1847) and Teichmann (in 1861) were the first to visualize and describe the conjunctival lymphatics.1 In 1948, Busacca2 identified a number of ...
Comment & Response 
Suqin Yu, MD; K. Bailey Freund, MD
To the Editor We read with great interest the recent article by Margo and Friedman titled “Progressive Outer Retinal Necrosis (PORN): A Catchy Acronym But Is the Anatomy Correct? The Salient Observation of Lorenz E. Zimmerman, MD.”1 The authors questioned the name of this disease because histological findings indicated that ...
Comment & Response 
Curtis E. Margo, MD, MPH; Scott M. Friedman, MD
In Reply Yu and Freund propose that the conflicting clinical and histological observations in PORN could be explained by retinal whitening from vascular occlusion of deep retinal capillaries, a process that immediately precedes inner retina injury followed by photoreceptor involvement. They base this hypothesis on recent observations by Sarraf et ...
Original Investigation 
Ronald B. Melles, MD; Michael F. Marmor, MD
Includes: Supplemental Content

Importance  Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations of risk were low but were based largely on short-term users or severe retinal toxicity (bull’s eye maculopathy). The risk may be much higher because retinopathy ...

Brief Report 
Andrew M. J. Turnbull, BM; Michael Smith, FRCOphth; Mahesh Ramchandani, FRCS

Importance  Unlike other modes of long-distance travel, long-haul flights delay urgent, specialist medical treatment until the destination is reached or the plane is diverted. Angle-closure glaucoma (ACG) occurring during those flights results in considerable morbidity and may cause permanent visual loss. It is preventable in patients with ...

Ophthalmic Images 
Kapil G. Kapoor, MD; Andrew J. Barkmeier, MD
Graphic Jump LocationThis patient noted a yellow spot in her vision and optical coherence tomography revealed foveal shadowing from a pseudo-operculum. This classic case of xanthic scotoma is distinguished from a true operculum by the normal foveal contour.
Comment & Response 
Henri Sueke, FRCOphth; Arvind Chandna, FRCOphth
To the Editor We read with interest the article on 4.5-year visual acuity outcomes for the Infant Aphakia Treatment Study (IATS).1 This is clearly a well-thought-out and meticulously devised study.

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