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 Showing 1-20 of 88 Articles
Original Investigation 
Yuki Muraoka, MD, PhD; Akitaka Tsujikawa, MD, PhD; Masayuki Hata, MD; Kenji Yamashiro, MD, PhD; Ellabban Abdallah, MD; Ayako Takahashi, MD; Hideo Nakanishi, MD, PhD; Sotaro Ooto, MD, PhD; Teruyo Tanabe, MD, PhD; Nagahisa Yoshimura, MD, PhD
Includes: Supplemental Content

Importance  Paravascular retinal abnormalities are common in highly myopic eyes. However, affected areas may be underestimated, and the pathogenesis and effects on retinal function remain unclear.

Objective  To prospectively investigate the characteristics and pathogenesis of paravascular inner retinal defects (PIRDs).

Design, Setting, and Participants  Prospective ...

Original Investigation 
Xiaoxing Liu, MD; Jingjing Xiao, PhD; Hui Huang, PhD; Liping Guan, PhD; Kanxing Zhao, MD, PhD; Qihua Xu, MD; Xiumei Zhang, PhD; Xinyuan Pan, MD; Shun Gu, PhD; Yanhua Chen, PhD; Jianguo Zhang, PhD; Yulan Shen, PhD; Hui Jiang, PhD; Xiang Gao, PhD; Xiaoli Kang, PhD; Xunlun Sheng, PhD; Xue Chen, PhD; Chen Zhao, MD, PhD
Includes: Supplemental Content

Importance  Inherited retinal dystrophies (IRDs) are a group of retinal degenerative diseases presenting genetic and clinical heterogeneities, which have challenged the genetic and clinical diagnoses of IRDs. Genetic evaluations of patients with IRD might result in better clinical assessments and better management of patients.

Objective  To ...

Research Letter 
Simone L. Li, PhD; Reed M. Jost, MS; Sarah E. Morale, BS; Angie De La Cruz, BS; Lori Dao, MD; David Stager Jr, MD; Eileen E. Birch, PhD
Repeated experience with dichoptic perceptual learning tasks and dichoptic game play have been shown to be effective in improving the visual acuity of amblyopic children and adults.1- 4 However, whether the visual acuity gains achieved with binocular treatment are long lasting has not yet been addressed. We examined the durability ...
Research Letter 
Giuliano Scarcelli, PhD; Sebastien Besner, PhD; Roberto Pineda, MD; Patricia Kalout, MD; Seok Hyun Yun, PhD
Corneal mechanical strength is critical to withstanding intraocular pressure and maintaining normal shape.1,2 In keratoconus, the mechanical stability is compromised,3 which may lead to progressive morphological changes. Therefore, a noninvasive technique capable of accurately measuring the mechanical properties of the cornea may help us understand the mechanism of keratoconus development ...
Observation 
Michael F. Clamp, MD; J. Michael Jumper, MD; H. Richard McDonald, MD; Arthur D. Fu, MD; Brandon J. Lujan, MD
Idiopathic macular hole is a condition widely believed to result from disruption of retinal tissue due to anteroposterior vitreofoveal traction.1 Previous reports have used spectral-domain optical coherence tomography (SD-OCT) to demonstrate cross-sectional images of macular hole formation in the setting of vitreomacular traction.1- 3 Herein, we present sequential en face ...
Original Investigation 
Niloofar Piri, MD; Brooke L. W. Nesmith, MD, JD; Shlomit Schaal, MD, PhD
Includes: Supplemental Content

Importance  The presence of choroidal hyperreflective foci in Stargardt disease is, to our knowledge, a potentially new finding. Evaluation of these foci may aid in better understanding of the disease process.

Objectives  To report the presence of choroidal hyperreflective foci in spectral-domain optical coherence tomography (SD-OCT) ...

Original Investigation 
Seyhan Yazar, MOrth; Gabriel Cuellar-Partida, BSci; Charlotte M. McKnight, MBBS; Piriya Quach-Thanissorn; Jenny A. Mountain, MBA; Minas T. Coroneo, MD, MS; Craig E. Pennell, FRANZCOG; Alex W. Hewitt, FRANZCO; Stuart MacGregor, PhD; David A. Mackey, FRANZCO

Importance  Conjunctival UV autofluorescence (CUVAF) photography was developed to detect and characterize preclinical sunlight-induced ocular damage. Ocular sun exposure has been related to cases of pterygia and was recently negatively correlated with myopia. Hence, CUVAF has excellent potential as an objective biomarker of sun exposure. However, much ...

Original Investigation 
Paul Hahn, MD, PhD; Mina M. Chung, MD; Harry W. Flynn Jr, MD; Suber S. Huang, MD, MBA; Judy E. Kim, MD; Tamer H. Mahmoud, MD, PhD; SriniVas R. Sadda, MD; Pravin U. Dugel, MD
Includes: Supplemental Content

Importance  Aflibercept-related sterile inflammation, an event that is poorly understood, has been the subject of ongoing postmarketing reports.

Objective  To analyze cases of aflibercept-related sterile inflammation reported to the American Society of Retina Specialists (ASRS) Therapeutic Surveillance Committee (TSC), an independent task force formed to monitor ...

Observation 
Benjamin P. Nicholson, MD; Sophie J. Bakri, MD
Numerous mechanisms of vision loss in silicone oil–filled eyes have been described in the literature. Silicone oil can cause keratopathy, glaucoma, optic neuropathy, and cataract.1,2 There have been reports of unexplained severe vision loss in eyes with good visual potential with long-term silicone oil tamponade.3 Imaging and histological studies of ...
Comment & Response 
Stephen Gbejule Odaibo, MD
To the Editor It was with great interest that I read the recent article by Mrejen et al.1 I commend the authors for their foresight in the use of multimodality imaging to further characterize acute zonal occult outer retinopathy (AZOOR). The study’s importance was stated as “the multimodal imaging in ...
Original Investigation  FREE
Carolina P. B. Gracitelli, MD; Ricardo Y. Abe, MD; Andrew J. Tatham, FRCOphth; Peter N. Rosen, MD; Linda M. Zangwill, PhD; Erwin R. Boer, PhD; Robert N. Weinreb, MD; Felipe A. Medeiros, MD, PhD
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Evaluation of structural optic nerve damage is a fundamental part of diagnosis and management of glaucoma. However, the relationship between structural measurements and disability associated with the disease is not well characterized. Quantification of this relationship may help validate structural measurements as markers directly relevant to ...

Original Investigation 
Wei-Chi Wu, MD, PhD; Reyin Lien, MD; Pei-Ju Liao, PhD; Nan-Kai Wang, MD, PhD; Yen-Po Chen, MD, PhD; An-Ning Chao, MD; Kuan-Jen Chen, MD; Tun-Lu Chen, MD; Yih-Shiou Hwang, MD, PhD; Chi-Chun Lai, MD

Importance  Intravitreous injections of bevacizumab (IVB) have been found to be effective for the treatment of retinopathy of prematurity (ROP). However, serum levels of vascular endothelial growth factor (VEGF) have been found to be suppressed for 2 weeks after IVB in patients with ROP. Changes in serum ...

Observation 
Madhu Uddaraju, MS; Jeena Mascarenhas, MS; Manoranjan Das, MS; N. Venkatesh Prajna, MD, FRCS
This case report describes a rare and intriguing case of bilateral concentric ring-shaped opacities not associated with any ocular or systemic conditions.
Comment & Response 
R. Rand Allingham, MD; M. Bruce Shields, MD
To the Editor Choi et al1 concluded that optic disc tilt, which they classified as a disc ovality (ratio between the longest and shortest disc diameters) greater than 1.30, appeared to be associated with bihemispheric retinal nerve fiber layer defects in patients with early glaucoma and that this association is ...
To the Editor The Invited Commentary by Naseri and McLeod1 on immediate sequential cataract surgery (ISCS) compared with delayed sequential cataract surgery (DSCS) based on my physician perspective cost-analysis model2 is an excellent analysis that discusses how premium intraocular lens (IOL) use may affect this model. It also reviews various ...
Comment & Response 
Jin A. Choi, MD, PhD; Chan Kee Park, MD, PhD
In Reply We thank Allingham and Shields for their kind interest in our article on the optic disc appearance associated with bihemispheric retinal nerve fiber layer (RNFL) defects in patients with early glaucoma.1 Concerns have been raised regarding how the disc dimensions were determined in this study. Optic disc tilt ...
Original Investigation 
Stacy L. Pineles, MD; Joseph L. Demer, MD, PhD; Sherwin J. Isenberg, MD; Eileen E. Birch, PhD; Federico G. Velez, MD

Importance  Binocular summation (BiS), or improvement in visual acuity using binocular vision compared with the better eye alone, is diminished in patients with strabismus. However, it is still not known how strabismus surgery affects BiS.

Objective  To determine whether BiS improves after strabismus surgery.

Design, Setting, ...

Original Investigation 
Mingwei Zhao, MD; Feng Zhang, MD; Youxin Chen, MD; Hong Dai, MD; Jinfeng Qu, MD; Chongya Dong, MS; Xiaoping Kang, MS; Yuling Liu, MD; Liu Yang, MD; Yibin Li, MD; Peng Zhou, MD; Chung-ting Pan, MD; Lijuan Zhang, MD; Peipei Liu, MD; Haiying Zhou, MD; Xuan Jiao, MD; Ying Xiong, MD; Rong Tian, MD; Yingyi Lu, MD; Xiaobing Yu, MD; Xiaoxin Li, MD
Includes: Supplemental Content

Importance  A randomized clinical trial is needed to evaluate what is the best photodynamic therapy (PDT) protocol to use for acute central serous chorioretinopathy.

Objective  To compare the efficacy and safety of a 50% dose of verteporfin (a method of PDT) with the efficacy and safety ...

Original Investigation 
The AJCC Ophthalmic Oncology Task Force
Includes: Supplemental Content

Importance  Although an accurate uveal melanoma staging system is needed to improve research and patient care, the evaluation of eye cancer staging systems requires international multicenter data sharing to acquire a statistically significant analysis.

Objective  To assess patient mortality outcomes associated with uveal melanoma staging according ...

Comment & Response 
Matthew D. Walvick, DO; Chau H. Ngo, PharmD
To the Editor We commend Mititelu et al1 on their recent study of hydroxychloroquine toxic effects but take issue with their conclusion. We believe prevention rather than early detection is best practice. Hydroxychloroquine is dosed by lean (“ideal”) body weight, which is based purely on height and sex. It is ...
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