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 Showing 1-20 of 61 Articles
Brief Report 
Cheryl E. Sherrod, MD, MPH; Susan Vitale, PhD, MHS; Kevin D. Frick, PhD; Pradeep Y. Ramulu, MD, MHS, PhD

Importance  Working is critical to personal health and well-being. We examine the association of vision measured objectively with work status using a nationally representative sample of working-age Americans.

Observation  A total of 19 849 participants from the 1999-2008 National Health and Nutrition Examination Survey completed a vision ...

Ophthalmic Images 
Christina Gerth-Kahlert, MD; Rike Michels, MD; Jens Funk, MD; Ursula Gautschy, OT
Graphic Jump LocationColor anterior segment imaging showing a bilateral congenital lamellar cataract in a 6.5-year-old girl (visual acuity, 20/70). Small central opacification and peculiar posterior disruption of the cortical alignment are visible in both the right eye (A) and the left eye (B). Visual acuity improved to 20/25 in both ...
Topics: cataract; eye
Mircea N. Coca, MD, PhD; Sohrab Tofigh, MD; Ahmed Elkeeb, MD; Bernard F. Godley, MD, PhD, MBA
Optic disc pit (ODP) is a rare congenital cavitation in the optic nerve head frequently associated with serous detachments of the macula, ODP maculopathy (ODP-M), and subsequent visual decline.1 Optic disc pit maculopathy is preceded by development of a schisis cavity due to accumulation of intraretinal fluid from the ODP. ...
David R. Lally, MD; Jay S. Duker, MD; John E. Mignano, MD, PhD; Stephen Martin, MD; Andre J. Witkin, MD
Includes: Supplemental Content
Uveal metastasis is often managed by external beam radiation therapy requiring multiple treatment sessions for the patient. We report the first case, to our knowledge, of regression of choroidal metastasis from breast carcinoma after 1 treatment with Leksell Gamma Knife (GK) stereotactic radiosurgery.

Importance  The cost difference is evaluated between delayed sequential cataract surgery (DSCS) and immediate sequential cataract surgery (ISCS) in the United States for patients covered by Medicare.

Objective  To perform a cost-minimization analysis comparing ISCS with DSCS in the United States from the payer, patient, and ...

Original Investigation 
Carol L. Shields, MD; Jeffrey F. McMahon, BS; Hatice T. Atalay, MD; Murat Hasanreisoglu, MD; Jerry A. Shields, MD
Includes: Supplemental Content

Importance  Metastatic tumors of the retina are rare, simulate retinitis, and are associated with poor patient survival.

Objective  To describe the clinical features and outcomes of patients with retinal metastasis from systemic cancer.

Design, Setting, and Participants  Retrospective case series of 8 patients with retinal ...

Brief Report 
Joshua H. Hou, MD; Kavitha R. Sivaraman, MD; Jose de la Cruz, MD; Amy Y. Lin, MD; Maria Soledad Cortina, MD

Importance  Retroprosthetic membrane (RPM) formation is the most common complication associated with the Boston type 1 keratoprosthesis and has been associated with corneal melt.

Objective  To identify the histological and immunohistochemical characteristics of RPMs associated with corneal melt.

Design, Setting, and Participants  Observational histopathological case ...

Ophthalmic Images 
Amir A. Azari, MD; Mozhgan Rezaei Kanavi, MD; Pimkwan Jaru-ampornpan, MD; Sherif S. Khedr, MD; Heather D. Potter, MD; Daniel M. Albert, MD; Neal P. Barney, MD
Graphic Jump LocationA 23-year-old man presented with a 2-year history of a slow growing lesion in the left eye. The lesion consisted of a vascularized, balloon-like mass straddling the limbus nasally (A). Histopathologic examination demonstrates (B) a conjunctival epithelium with solar elastosis, consistent with a pterygium (left side), and proliferation ...
Topics: nevus; eye; pterygium
Research Letter 
Joon-Bom Kim, BA; Abdallah Jeroudi, MD; Sheila T. Angeles-Han, MD; Hans E. Grossniklaus, MD; Steven Yeh, MD
Sympathetic ophthalmia (SO) is an autoimmune, bilateral, granulomatous panuveitis occurring after accidental or surgical trauma to the eye.1 Systemic corticosteroids are first-line therapy for SO, with immunomodulatory therapy used for corticosteroid-sparing immunosuppression and chronic, refractory cases. Biological response modifiers are a class of therapeutics that target specific cytokines mediating inflammation, ...
Research Letter  FREE
Claudine E. Pang, MD; K. Bailey Freund, MD; Michael Engelbert, MD, PhD
Vitreous degeneration, gradual separation of the posterior vitreous cortex (PVC), and eventual development of posterior vitreous detachment (PVD) are important in vitreoretinal interface diseases. However, determination of the stages of PVD with biomicroscopy or ultrasonography is not sufficiently sensitive and specific.1,2 Since the advent of spectral-domain (SD) optical coherence tomography ...
Samuel G. Jacobson, MD, PhD; Artur V. Cideciyan, PhD; Alexander Sumaroka, PhD; Alejandro J. Roman, MSc; Alan F. Wright, MB, PhD
Two decades ago, a postmortem eye donor study identified a unique autosomal dominant disease and named it late-onset retinal degeneration (L-ORD).1 The distinguishing feature of L-ORD was a retina-wide thick layer of extracellular deposit between the retinal pigment epithelium (RPE) and Bruch membrane. A founder mutation, p.Ser163Arg, in C1QTNF5 was ...
Original Investigation 
Li-Xia Lou, MD; Kai-Min Hu, MD; Kai Jin, MD; Su-Zhan Zhang, MD, PhD; Juan Ye, MD, PhD
Includes: Supplemental Content

Importance  To date, no consistency exists across studies that have evaluated the relationship between hepatic lipase gene (LIPC) rs10468017 variant and advanced age-related macular degeneration (AMD).

Objective  To summarize all relevant evidence for a relationship between LIPC variant and advanced AMD.

Data Sources  ...

Original Investigation 
Uri Elbaz, MD; Robert Bains, MBChB, FRCS(Plast); Ronald M. Zuker, MD, FRCSC; Gregory H. Borschel, MD; Asim Ali, MD, FRCSC

Importance  Corneal anesthesia is recalcitrant to conventional treatment and can lead to permanent visual loss.

Objective  To assess the outcomes of a novel sensory reconstructive technique for the treatment of corneal anesthesia.

Design, Setting, and Participants  This prospective study evaluating a new technique was conducted ...

Ophthalmic Images 
Matthew S. J. Katz, MD; Erin K. Walsh, MD; Norman B. Medow, MD
Graphic Jump LocationFundus photographs of the right eye in the vitelliform stage with a “fried egg” appearance due to the accumulation of lipofuscin in retinal pigment epithelial cells (A), the left eye in the vitelliform stage with a “fried egg” appearance and pseudohypopyon (B), the right eye in the “scrambled ...
Veena Rao, MD, MSc; Eric Schneider, MD; Alan D. Proia, MD, PhD; Sharon Fekrat, MD
Toxoplasma gondii retinochoroiditis is the most common cause of posterior uveitis in North America.1 Immunocompromised patients are particularly susceptible, and bilateral acquired toxoplasmic retinochoroiditis is thought to be rare without immunosuppression.1,2 We describe a woman who developed bilateral acquired toxoplasmic retinochoroiditis while undergoing treatment with erlotinib hydrochloride, an epidermal growth ...
Jerry A. Shields, MD; Ralph C. Eagle Jr, MD; Jonathan Dutton, MD; Hormoz Ehya, MD; Carol L. Shields, MD
True neoplasms can arise from pigment epithelium of the iris, ciliary body, and retina (retinal pigment epithelium [RPE]).1- 4 We report a large adenocarcinoma of RPE that was a diagnostic challenge based on clinical features, cytopathology, and immunohistochemistry. However, with routine histopathology of the enucleated eye, the diagnosis of RPE ...
Original Investigation 
Claire Monnereau, MSc; Ruth Quilendrino, MD; Isabel Dapena, MD, PhD; Vasilios S. Liarakos, MD; Jose F. Alfonso, MD, PhD; Francisco Arnalich-Montiel, MD, PhD; Matthias Böhnke, MD, PhD; Nicolas Cesário Pereira, MD; Martin Dirisamer, MD; John Parker, MD; Konstantinos Droutsas, MD, PhD; Gerd Geerling, MD, PhD; Georg Gerten, MD, PhD; Hassan Hashemi, MD; Akira Kobayashi, MD, PhD; Miguel Naveiras, MD; Oganes Oganesyan, MD, PhD; Emeterio Orduña Domingo, MD; Siegfried Priglinger, MD, FEBO; Pavel Stodulka, MD; José Torrano Silva Jr, MD, PhD; Davide Venzano, MD; Jan Markus Vetter, MD, PhD; Evan Yiu, MD; Gerrit R. J. Melles, MD, PhD
Includes: Supplemental Content

Importance  Surgeons starting to perform Descemet membrane endothelial keratoplasty (DMEK) should be informed about the learning curve and experience of others.

Objective  To document the clinical outcome of standardized “no-touch” DMEK and its complications during the learning curves of experienced surgeons.

Design, Setting, and Participants  ...

Original Investigation 
Michael A. Sandberg, PhD; Elizabeth N. Pearce, MD; Shyana Harper, MSc; Carol Weigel-DiFranco, MA; Lois Hart, RDMS; Bernard Rosner, PhD; Eliot L. Berson, MD

Importance  Current treatments for cystoid macular edema (CME) in retinitis pigmentosa (RP) are not always effective, may lead to adverse effects, and may not restore visual acuity. The present research lays the rationale for evaluating whether an iodine supplement could reduce CME in RP.

Objective  To ...

Original Investigation 
Alan F. Scott, PhD; David W. Mohr, BA; Laura M. Kasch, BS; Jill A. Barton, MS; Raquel Pittiglio, MS; Roxann Ingersoll, MHS; Brian Craig, MS; Beth A. Marosy, MS; Kimberly F. Doheny, PhD; William C. Bromley, MD; Thomas H. Roderick, PhD†; Nicolas Chassaing, MD; Patrick Calvas, MD; Shreya S. Prabhu, MD; Ethylin Wang Jabs, MD
Includes: Supplemental Content

Importance  Microphthalmias are rare disorders whose genetic bases are not fully understood. HMGB3 is a new candidate gene for X-linked forms of this disease.

Objective  To identify the causative gene in a pedigree with an X-linked colobomatous microphthalmos phenotype.

Design, Setting, and Participants  Whole-genome sequencing ...

Brief Report 
Ingrid U. Scott, MD, MPH; Gregory R. Jackson, PhD; David A. Quillen, MD; Ronald Klein, MD; Jason Liao, PhD; Thomas W. Gardner, MD, MS

Importance  Microglia have been associated with inflammatory changes underlying diabetic retinopathy.

Objective  To investigate whether low-dose oral doxycycline monohydrate, a drug capable of inhibiting microglial activation, can improve or slow the deterioration of retinal function and whether it can induce regression or slow progression of diabetic ...

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