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 Showing 1-20 of 63 Articles
Original Investigation 
Amy E. Millen, PhD; Kristin J. Meyers, PhD, MPH; Zhe Liu, MS; Corinne D. Engelman, PhD; Robert B. Wallace, MD; Erin S. LeBlanc, PhD; Lesley F. Tinker, PhD; Sudha K. Iyengar, PhD; Jennifer G. Robinson, MD; Gloria E. Sarto, MD, PhD; Julie A. Mares, PhD
Includes: Supplemental Content

Importance  Deficient 25-hydroxyvitamin D (25[OH]D) concentrations have been associated with increased odds of age-related macular degeneration (AMD).

Objective  To examine whether this association is modified by genetic risk for AMD and whether there is an association between AMD and single-nucleotide polymorphisms of genes involved in vitamin ...

Original Investigation  FREE
Jeannette Beckman Rehnman, RN; Christina Lindén, MD, PhD; Per Hallberg, PhD; Anders Behndig, MD, PhD
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  We describe and evaluate a complementary method to indirectly quantify the treatment effect of corneal cross-linking (CXL). Additional methods to indirectly quantify the treatment effect of CXL are needed.

Objective  To assess the spatial distribution and the time course of the increased corneal densitometry (corneal ...

Brief Report 
Ian C. Han, MD; Mongkol Tadarati, MD; Adrienne W. Scott, MD
Includes: Supplemental Content

Importance  Patients with sickle cell disease may develop various macular vascular abnormalities that have not been described previously and can be seen using optical coherence tomographic angiography.

Observations  Ten eyes from 5 consecutive patients (3 men and 2 women) with sickle cell disease (4 patients with ...

JAMA Ophthalmology Clinical Challenge 
Sneh S. Dhannawat, MBBS; Amulya A. Nageswara Rao, MBBS; Michael C. Brodsky, MD

A 7-month-old boy presents with an emaciated appearance and monocular nystagmus, with no associated strabismus, head nodding, or torticollis. What Would You Do Next?

Yulia Wolfson, MD; Carolyn D. Applegate, MGC; Rupert W. Strauss, MD; Ian C. Han, MD; Hendrik P. Scholl, MD

This case series describes twin sisters with cystoid macular edema related to a CRB1 mutation.

Original Investigation  FREE
Carolyn P. Graeber, MD; David G. Hunter, MD, PhD
Includes: Supplemental Content

Importance  Asymmetric horizontal strabismus surgery is often performed to correct primary gaze alignment without considering the symptoms that may result from misalignment in the patient’s side gaze. Surgical choices influence alignment in side gaze and may contribute to functional and social deficits.

Objective  To identify the ...

Original Investigation  FREE
Imran Mahmud, MD, MPH; Thomas Kelley, MD, MBA; Caleb Stowell, MD; Aravind Haripriya, MD, MS; Anders Boman, MD; Ingrid Kossler, MBA; Nigel Morlet, FRANZCO, FRACS; Suzann Pershing, MD, MS; Konrad Pesudovs, PhD; Pik Pin Goh, MD, MS; John M. Sparrow, DPhil, FRCOphth; Mats Lundström, MD, PhD

Importance  Aligning outcome measures for cataract surgery, one of the most frequently performed procedures globally, may facilitate international comparisons that can drive improvements in the outcomes most meaningful to patients.

Objective  To propose a minimum standard set of outcome measures for cataract surgery that enables global ...

Invited Commentary: The Universal Language of Cataract Surgery; Bonnie An Henderson, MD
Brief Report 
Omar A. Mahroo, PhD, FRCOphth; Danny Mitry, PhD; Tom H. Williamson, MD, FRCOphth; Ashley Shepherd, BSc, MS; David G. Charteris, FRCOphth; Robin D. Hamilton, DM, FRCOphth

Importance  Studies have consistently reported a small preponderance of rhegmatogenous retinal detachments in males and in right eyes, which might suggest interesting differences in ocular anatomy relating to sex and laterality. However, an important potential confounding factor is that epidemiologic studies do not consider retinal tears that ...

Invited Commentary 
Bonnie An Henderson, MD

Governmental health care organizations, such as Medicare, are increasingly evaluating the success of care based on patient outcomes and cost. As such, health care professionals will need to follow not only clinical outcomes but the subjective outcomes of patient satisfaction and the overall cost of care.1 Historically, ...

Comment & Response 
Catey Bunce, DSc; Richard Wormald, FRCOphth

To the Editor We read the recent article by Glassman and Melia1 with great interest. The authors recommend that careful consideration should be given in ophthalmic clinical trials to enrollment of both eyes when possible and highlight aspects of study design to consider. We support these recommendations ...

Comment & Response 
Adam R. Glassman, MS; Michele Melia, ScM

In Reply We agree with Bunce and Wormald that all important information regarding an individual’s participation in a trial including the option of enrolling 1 or both eyes and whether the eyes will receive different treatments if both are enrolled must be explained in the informed consent form ...

Lawrence I. Rand, MD; Frederick L. Ferris III, MD

This Viewpoint explores progress in the process and treatment of diabetes mellitus by long-term follow-up of the Diabetes Control and Complications Trial.

Original Investigation  FREE
Brian L. VanderBeek, MD, MPH; Sarah G. Bonaffini, BS; Liyuan Ma, MS

Importance  Current draft guidelines set forth by the US Food and Drug Administration for compounded or repackaged medications would greatly limit the availability and use of bevacizumab by ophthalmologists across the country. Little evidence beyond highly publicized case reports exists for or against the need for additional ...

Original Investigation 
Rosa Dolz-Marco, MD; Murat Hasanreisoglu, MD; Jerry A. Shields, MD; Carol L. Shields, MD
Includes: Supplemental Content

Importance  Recognition of posterior scleral bowing with choroidal nevus is essential to avoid an underestimation of tumor thickness.

Objective  To describe a particular observation of posterior scleral bowing associated with choroidal nevus on enhanced-depth imaging (EDI) optical coherence tomography (OCT).

Design, Setting, and Participants  Retrospective ...

Brief Report 
Miaoling Li, MD; Xiongze Zhang, MD, PhD; Yuying Ji, MD; Baikang Ye, MD; Feng Wen, MD, PhD

Importance  The incidence of dengue fever (DF) increases every year. Macular complications of patients with DF may be more common than many ophthalmologists realize. During a DF outbreak in South China in 2014, we observed acute macular neuroretinopathy associated with DF.

Observations  Among 9 patients (17 ...

JAMA Ophthalmology Clinical Challenge 
Tavé van Zyl, MD; Thanos D. Papakostas, MD; Lucia Sobrin, MD, MPH

A young man presented with a 1-day history of vision loss in the left eye, eye redness for 1 week, a mild posterior headache, and tingling and numbness of the left thumb and index and middle fingers. What would you do next?

Original Investigation  FREE
Shuai-Chun Lin, MD; Kuldev Singh, MD; Shan C. Lin, MD

Importance  Abnormal body levels of essential elements and exposure to toxic trace metals have been postulated to contribute to the pathogenesis of diseases affecting many organ systems, including the eye.

Objective  To investigate associations between body levels of trace metals and the prevalence of glaucoma in ...

Original Investigation 
Seung Hyen Lee, MD; Eun Ji Lee, MD; Tae-Woo Kim, MD
Includes: Supplemental Content

Importance  The optic disc pit (ODP) has been considered a region of localized susceptibility to the damage of glaucoma.

Objective  To determine whether the rate of retinal nerve fiber layer (RNFL) thinning differs according to the presence and structural characteristics of an ODP in primary open-angle ...

Brief Report 
Hongxin Song, PhD; Ethan A. Rossi, PhD; Lisa Latchney, MS; Angela Bessette, MD; Edwin Stone, MD, PhD; Jennifer J. Hunter, PhD; David R. Williams, PhD; Mina Chung, MD
Includes: Supplemental Content

Importance  Stargardt disease (STGD1) is characterized by macular atrophy and flecks in the retinal pigment epithelium. The causative ABCA4 gene encodes a protein localizing to photoreceptor outer segments. The pathologic steps by which ABCA4 mutations lead to clinically detectable retinal pigment epithelium changes remain unclear. We investigated ...

Matthew T. Feng, MD; Francis W. Price Jr, MD; Yuri McKee, MD; Marianne O. Price, PhD

This case report describes corneal endothelial dysfunction in a patient being treated with memantine for Alzheimer disease.

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