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 Showing 1-20 of 67 Articles
Ophthalmic Images 
Lauren S. Taney, MD; Caroline R. Baumal, MD
Graphic Jump LocationCystic retinal tuft (CRT) is a developmental vitreoretinal abnormality found in 5% of autopsy eyes. Clinical examination reveals a focal, elevated gliotic lesion in the peripheral retina associated with vitreous traction (Figure, A and B). Histopathological analysis demonstrates a dome-shaped area with internal microcysts, glial cell proliferation, outer ...
Research Letter 
Eleonora M. Lad, MD, PhD; Christine M. Hulette, MD; Alan D. Proia, MD, PhD
Primary angiitis of the central nervous system (PACNS), also known as primary vasculitis of the central nervous system, is a rare, poorly understood, and often fatal disorder.1,2 Although the association of PACNS with optic neuropathy has been documented,3- 5 this is the first report to our knowledge of visual loss ...
Leonard Goussard Heydenrych, FCOphth (SA), FRCOphth; Colleen Michelle Aldous, PhD; Roy Giles, FCRad (SA); Grant Andre du Plessis, MMED Neurosurg (Stell); Burnet Meyer, MMED Ophth (Stell), FCS (SA)
Distinguishing between a cerebrospinal fluid (CSF) collection of the upper eyelid and an abscess can be challenging, as the following case demonstrates. Each may be preceded by surgical intervention and both could present with pyrexia. Good clinical skills will assist in differentiation, but laboratory tests are required to provide the ...
Original Investigation 
Mi Jeung Kim, MD; Seok Hwan Kim, MD, PhD; Young Hoon Hwang, MD; Ki Ho Park, MD, PhD; Tae-Woo Kim, MD, PhD; Dong Myung Kim, MD, PhD
Includes: Supplemental Content

Importance  To our knolwedge, there is no reliable screening method for glaucomatous eyes with myopic tilted discs.

Objective  To evaluate the diagnostic ability of a novel screening modality, the crescent moon (CM) sign, defined as the discontinuity between the superior or inferior optic rim margin and ...

Original Investigation 
Sharon L. Christ, PhD; D. Diane Zheng, MS; Bonnielin K. Swenor, PhD; Byron L. Lam, MD; Sheila K. West, PhD; Stacey L. Tannenbaum, PhD; Beatriz E. Muñoz, MSc; David J. Lee, PhD
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Determination of the mechanisms by which visual loss increases mortality risk is important for developing interventional strategies.

Objective  To evaluate the direct and indirect effects of loss of visual acuity (VA) on mortality risk through functional status changes among aging adults.

Design, Setting, and Participants...

Ophthalmic Images 
Amit Gupta, MS; Aniruddha Agarwal, MS; Jagat Ram, MS
Graphic Jump LocationA, Patient receiving unsupervised chlorpromazine therapy presented with low vision and darkened skin of face and hands. B, Diffusely scattered star-shaped granular deposits were seen on cornea (arrowhead). C, Dirty-white anterior lenticular opacities seen (arrowhead). D, Resolution of pigmentation occurred following drug withdrawal.
Topics: chlorpromazine; eye
Christina Y. Weng, MD, MBA; D. Wilkin Parke III, MD; Scott D. Walter, MD; Ryan F. Isom, MD; Jonathan S. Chang, MD; Harry W. Flynn Jr, MD
Includes: Supplemental Content
Fungal endophthalmitis is a recognized but uncommon complication following corneal transplantation procedures.1 Herein, we describe a patient with Candida glabrata endophthalmitis subsequent to Descemet stripping automated endothelial keratoplasty (DSAEK) with graft-to-host transmission. To our knowledge, this is the first report in the literature of a patient who developed C glabrata ...
Original Investigation 
Johane M. Robitaille, MD; Roxanne M. Gillett, PhD; Marissa A. LeBlanc, PhD; Daniel Gaston, PhD; Mathew Nightingale, HND; Michael P. Mackley, BSc; Sandhya Parkash, MD; Julie Hathaway, MSc; Aidan Thomas, MSc; Anna Ells, MD; Elias I. Traboulsi, MD; Elise Héon, MD; Mélanie Roy, MD; Stavit Shalev, MD; Conrad V. Fernandez, MD; Christine MacGillivray, BSc; Karin Wallace, BSc; Somayyeh Fahiminiya, PhD; Jacek Majewski, PhD; Christopher R. McMaster, PhD; Karen Bedard, PhD
Includes: Supplemental Content

Importance  Retinal detachment with avascularity of the peripheral retina, typically associated with familial exudative vitreoretinopathy (FEVR), can result from mutations in KIF11, a gene recently identified to cause microcephaly, lymphedema, and chorioretinal dysplasia (MLCRD) as well as chorioretinal dysplasia, microcephaly, and mental retardation (CDMMR). Ophthalmologists should ...

Original Investigation 
Rohit Varma, MD, MPH; Neil M. Bressler, MD; Quan V. Doan, PharmD; Michelle Gleeson, PhD; Mark Danese, PhD; Julie K. Bower, PhD; Elizabeth Selvin, PhD; Chantal Dolan, PhD; Jennifer Fine, PhD; Shoshana Colman, PhD; Adam Turpcu, PhD
Includes: Supplemental Content

Importance  Diabetic macular edema (DME) is a leading cause of vision loss in persons with diabetes mellitus. Although there are national estimates for the prevalence of diabetic retinopathy and its risk factors among persons with diabetes, to our knowledge, no comparable estimates are available for DME specifically. ...

Original Investigation 
Mikael Guedj, MD; Astrid Quéant, MD; Elisa Funck-Brentano, MD; Nora Kramkimel, MD; Judith Lellouch, MD; Dominique Monnet, MD, PhD; Christine Longvert, MD, PhD; Amelie Gantzer, MD; Antoine P. Brézin, MD, PhD

Importance  This case series highlights the risk of uveitis in patients treated with vemurafenib for unresectable or metastatic cutaneous melanoma.

Objective  To assess the occurrence and severity of uveitis as an adverse effect of vemurafenib therapy.

Design, Setting, and Patients  In this observational small case ...

Andrew M. Schimel, MD; Eduardo C. Alfonso, MD; Harry W. Flynn Jr, MD
Endophthalmitis prophylaxis for elective cataract surgery is a subject of considerable debate. The use of perioperative povidone-iodine and an eyelid speculum and drape with isolation of eyelids and eyelashes as well as meticulous sterile preparation and procedures are effective in limiting the incidence of endophthalmitis after cataract surgery.1 The rapid ...
Ophthalmic Images 
Sabyasachi Sengupta, DNB, FRCS
Graphic Jump LocationA healthy man in his late 30s experienced sudden visual loss and presented with an extremely rare combination of branch retinal artery (black arrowhead) and vein (white arrowhead) occlusion that progressed to neovascular glaucoma. Blood workup revealed hyperhomocysteinemia (homocysteine level, 52 μmol/L [to convert to milligrams per liter, ...
Frederick A. Jakobiec, MD, DSc; Alia Rashid, MBChB; Erik Letko, MD
Lymphoid tumors of the conjunctiva, also referred to clinically as salmon patches, have a favorable prognosis.1,2 They are composed of reactive lymphoid hyperplasias and low-grade lymphomas. To our knowledge, associated intralymphatic lymphocytostasis has received no attention in the ophthalmic literature, and we describe it herein.
Original Investigation 
Megan M. Geloneck, MD; Alice Z. Chuang, PhD; W. Lloyd Clark, MD; Michael G. Hunt, MD; Alan A. Norman, MD; Eric A. Packwood, MD; Khaled A. Tawansy, MD; Helen A. Mintz-Hittner, MD; for the BEAT-ROP Cooperative Group
Includes: Supplemental Content

Importance  Children born prematurely who develop retinopathy of prematurity (ROP) often develop myopia, and those who require laser treatment may develop very high myopia, which has considerable clinical consequences.

Objective  To report refractive outcomes in preterm infants who developed ROP in zone I or zone II ...

Surgical Technique 
Vincenzo Scorcia, MD; Jacqueline Beltz, MD, FRANZCO; Massimo Busin, MD
Stromal disease (ectasia, opacities, scars, or melting) that occurs after penetrating keratoplasty (PK) can variously affect visual outcome.1,2 To date, even in the presence of healthy endothelium, this type of complication has been treated with subsequent PK.3 Instead, the selective replacement of the diseased stroma by means of deep anterior ...
Optogenetics is a technology that uses gene therapy to induce the expression of light-activated ion channels in cells, which renders the cells light-sensitive. When these cells are illuminated with light of the proper wavelength, membrane depolarization (or hyperpolarization) is induced by the light-sensitive ion channels, and if the cells are ...
Topics: vision; optogenetics
Brief Report 
Michael Banitt, MD; Florence Cabot, MD; Rehan Hussain, MD; Sander Dubovy, MD; Sonia H. Yoo, MD

Importance  The femtosecond laser is reported to cut lamellar surfaces with varying degrees of smoothness depending on the depth of the cut, with deeper cuts leaving less smooth surfaces. We attempted to evaluate the smoothness of the deeper lamellar surface as cut by the femtosecond laser after ...

Ophthalmic Images 
Carlos A. Medina Mendez, MD; Patrick C. Ma, MD; Arun D. Singh, MD
Graphic Jump LocationFront (A) and lateral (B) external photographs of a woman in her early 60s who had undergone treatment with erlotinib for more than 2 and a half years. She developed bilateral trichomegaly, which required constant trimming.
Topics: eye; erlotinib
Research Letter 
Emiliano Buitrago, Bsc; Eduardo Lagomarsino, PhD; Gabriel Mato, PharmD; Paula Schaiquevich, PhD
Intravitreal injections for the treatment of retinoblastoma have been gaining relevance among ophthalmologists, supported by reports on outcome and improvement of the administration technique.1 Currently, doses up to 30 μg per injection are used according to an extensively described technique for intravitreal injection that minimizes the risk of extraocular dissemination ...
Stephen M. Huddleston, MD; Kourtney H. Houser, MD; R. Christopher Walton, MD
Scleritis is an uncommon manifestation of sarcoidosis. Initial treatment for most patients is systemic corticosteroids, although immunomodulatory therapy is necessary in some patients. Biological response modifiers such as tumor necrosis factor (TNF) antagonists may be useful in patients with scleritis refractory to immunomodulatory therapy.1 Patients who fail therapy with TNF ...

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