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 Showing 1-20 of 69 Articles
Viewpoint  FREE
Camila V. Ventura, MD; Thomas A. Albini, MD; Audina M. Berrocal, MD

This Viewpoint discusses the response to the Zika virus cases identified in Florida.

Original Investigation 
Samir N. Patel, MD; Michael A. Klufas, MD; Christina E. Douglas, BA; Karyn E. Jonas, RN; Susan Ostmo, MPH; Audina Berrocal, MD; Antonio Capone Jr, MD; Maria A. Martinez-Castellanos, MD; Felix Chau, MD; Kimberly Drenser, MD; Philip Ferrone, MD; Anton Orlin, MD; Irena Tsui, MD; Wei-Chi Wu, MD; Mrinali P. Gupta, MD; Michael F. Chiang, MD; R. V. Paul Chan, MD; for the i-ROP Research Consortium
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Telemedicine is becoming an increasingly important component of clinical care for retinopathy of prematurity (ROP), but little information exists regarding the role of mosaic photography for ROP telemedicine diagnosis.

Objective  To examine the potential effect of computer-generated mosaic photographs on the diagnosis and management of ...

Original Investigation  FREE
Anat Galor, MD, MSPH; Roy C. Levitt, MD; Katherine T. McManus, BS; Jerry P. Kalangara, MD; Benjamin E. Seiden, BS; Jasmine J. Park, BS; Derek B. Covington, MD; Constantine D. Sarantopoulos, MD, PhD; Elizabeth R. Felix, PhD
Includes: Supplemental Content

Importance  Somatosensory dysfunction likely underlies dry eye (DE) symptoms in many individuals yet remains an understudied component of the disease. Its presence has important diagnostic and therapeutic implications.

Objective  To assess the integrity of nociceptive system processes in persons with DE and ocular pain using quantitative ...

Invited Commentary: Remote Quantitative Sensory Testing and Neuropathic Ocular Pain; Mark I. Rosenblatt, MD, PhD
Brief Report 
Aristomenis Thanos, MD; Lisa J. Faia, MD; Yoshihiro Yonekawa, MD; Sandeep Randhawa, MD

Importance  Acute macular neuroretinopathy (AMN) is a rare, yet increasingly recognized, entity identified predominantly in young healthy females with acute onset of paracentral scotomas. The exact pathophysiology is unknown but an underlying vascular process is suspected. This study used optical coherence tomographic angiography (OCTA) to assess for ...

Invited Commentary 
Mark I. Rosenblatt, MD, PhD

The ocular surface, by virtue of its dense innervation, is one of the most sensitive tissues in the body.1 Indeed, many of the millions of patients with ocular disease experience symptoms ranging from mild discomfort and “dryness” to frank pain, which can in some cases be debilitating. ...

JAMA Ophthalmology Clinical Challenge 
Vlad M. Matei, MD; Jennifer H. Cao, MD; C. Stephen Foster, MD

A 64-year-old man presented with 3 weeks of bilateral anterior uveitis unresponsive to treatment with topical steroids and experienced worsening uveitis and ocular hypertension. What would you do next?

Original Investigation 
Graham E. Quinn, MD, MSCE; Anna Ells, MD; Antonio Capone Jr, MD; G. Baker Hubbard, MD; Ebenezer Daniel, MD, PhD; P. Lloyd Hildebrand, MD; Gui-shuang Ying, PhD; for the e-ROP (Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity) Cooperative Group

Importance  As effective treatments for potentially blinding retinopathy of prematurity (ROP) have been introduced, the importance of consistency in findings has increased, especially with the shift toward retinal imaging in infants at risk of ROP.

Objective  To characterize discrepancies in findings of ROP between digital retinal ...

Invited Commentary: Telemedicine for Retinopathy of Prematurity; Ingrid E. Zimmer-Galler, MD
Original Investigation 
Johanna M. Seddon, MD, ScM; D. Scott McLeod; Imran A. Bhutto, MD, PhD; Mercedes B. Villalonga, BA; Rachel E. Silver, MPH; Adam S. Wenick, MD, PhD; Malia M. Edwards, PhD; Gerard A. Lutty, MS, PhD
Includes: Supplemental Content

Importance  Age-related macular degeneration (AMD) is a multifactorial disease with genetic and environmental factors contributing to risk. Histopathologic changes underlying AMD are not fully understood, particularly the relationship between choriocapillaris (CC) dysfunction and phenotypic variability of this disease.

Objective  To examine histopathologic changes in the CC ...

Invited Commentary: Insight Into Neovascular Age-Related Macular Degeneration; Thaddeus P. Dryja, MD
Invited Commentary 
Thaddeus P. Dryja, MD

One is occasionally struck by a basic scientific question that has been curiously neglected for study. Sometimes the question is neglected because everyone takes a presumed answer for granted. Sometimes nobody feels the question is of sufficient importance to warrant investigation. As an example of such a question, ...

Invited Commentary 
Ingrid E. Zimmer-Galler, MD

Telemedicine technology is increasingly being incorporated into mainstream ophthalmology. Remote fundus imaging is most frequently used in the context of screening for treatable retinal diseases, and robust ocular telehealth programs with mature reading centers now exist to identify vision-threatening diseases in patients with diabetes. Similar advances are being ...

JAMA Ophthalmology Clinical Challenge 
Ivy Zhu, BA; Andrew W. Francis, MD; M. Soledad Cortina, MD

A woman in her 30s with bilateral papilledema had an elevated optic disc with blurred margins and loss of the central physiologic cup on fundus examination. What would you do next?


In the Original Investigation titled “Evaluation of a Myopic Normative Database for Analysis of Retinal Nerve Fiber Layer Thickness,”1 published in the September issue of JAMA Ophthalmology, the wrong author’s name was listed with the financial disclosure included in the Conflict of Interest Disclosures section. The ...

Original Investigation 
Zachary Keenum, BS; Gerald McGwin Jr, PhD; C. Douglas Witherspoon, MD; Julia A. Haller, MD; Mark E. Clark; Cynthia Owsley, PhD

Importance  The public health success of diabetic retinopathy (DR) screening programs depends on patients’ adherence to the timetable of follow-up eye care recommended by the screening program. African Americans are among those at highest risk for DR and have one of the lowest rates of eye care ...

Invited Commentary: Improving Ocular Telehealth Outcomes; Christopher J. Brady, MD
Original Investigation 
Barbara M. Wirostko, MD; Karen Curtin, PhD; Robert Ritch, MD; Samuel Thomas, MD; Kristina Allen-Brady, PhD; Ken R. Smith, PhD; Gregory S. Hageman, PhD; R. Rand Allingham, MD

Importance  Exfoliation syndrome, an inherited systemic disorder of elastin and extracellular matrix (ECM), is associated with the LOXL1 gene locus. Pelvic organ prolapse is a common connective tissue disorder that affects women. The presence of an association between exfoliation syndrome (exfoliation of the lens capsule) and pelvic ...

Brief Report 
Daria Van Tyne, PhD; Joseph B. Ciolino, MD; Jay Wang, MD; Marlene L. Durand, MD; Michael S. Gilmore, PhD
Includes: Supplemental Content

Importance  Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are highly antibiotic resistant, and primary ocular infection by ESBL E coli has rarely been reported. A novel mutation conferring phagocytosis resistance would position a strain well to infect the cornea.

Observations  A woman with recurrent keratitis presented with a ...

Invited Commentary 
Christopher J. Brady, MD

It has now been well established that a nonmydriatic camera located well outside the ophthalmologist or optometrist office can be used to capture images of the retinal fundus for remote interpretation. In the setting of diabetic retinopathy, this “store-and-forward” paradigm has been validated against clinical examination and as ...

JAMA Ophthalmology Clinical Challenge 
Judy Chen, MD; Yannek Leiderman, MD, PhD; Aisha Traish, MD

An otherwise healthy white man in his 40s had decreased vision with a white cataract and tearing, photophobia, and burning in his left eye. He had been treated for a corneal abrasion and treated with topical antibiotics 1 year prior. What would you do next?

Research Letter  FREE
Jiufeng Sun, PhD; De Wu, PhD; Haojie Zhong; Dawei Guan; Huan Zhang; Qiqi Tan; Changwen Ke, PhD

This study examines whether Zika virus can be detected in conjunctival fluid.

Original Investigation 
Jennifer E. Thorne, MD, PhD; Eric Suhler, MD, MPH; Martha Skup, PhD; Samir Tari, MD, MBA; Dendy Macaulay, PhD; Jingdong Chao, PhD; Arijit Ganguli, PhD, MBA
Includes: Supplemental Content

Importance  Noninfectious uveitis (NIU) is a collection of intraocular inflammatory disorders that may be associated with significant visual impairment. To our knowledge, few studies have investigated NIU prevalence overall or stratified by inflammation location, severity, presence of systemic conditions, age, or sex.

Objective  To estimate NIU ...

Invited Commentary: Uveitides in the United States; Douglas A. Jabs, MD, MBA
Original Investigation 
Caroline L. S. Kilduff, MBBS; Edward J. Casswell, MBBS; Tahrina Salam, FRCOphth; Dov Hersh, MBBS, FRANZCO; Santiago Ortiz-Perez, PhD, FRCOphth; Daniel Ezra, MD, FRCOphth

Importance  Patients with benign essential blepharospasm or hemifacial spasm are known to use botulinum toxin injections and alleviating maneuvers to help control their symptoms. The clinical correlates between the use of botulinum toxin injections and the use of alleviating maneuvers are not well established.

Objective  To ...

Invited Commentary: Alleviating Maneuvers for Dystonias; Andrew G. Lee, MD; Neil R. Miller, MD

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