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 Showing 1-20 of 63 Articles
Original Investigation  FREE
Bruno de Paula Freitas, MD; João Rafael de Oliveira Dias, MD; Juliana Prazeres, MD; Gielson Almeida Sacramento, BS; Albert Icksang Ko, MD; Maurício Maia, MD, PhD; Rubens Belfort Jr, MD, PhD

Importance  The Zika virus (ZIKV) has rapidly reached epidemic proportions, especially in northeastern Brazil, and has rapidly spread to other parts of the Americas. A recent increase in the prevalence of microcephaly in newborn infants and vision-threatening findings in these infants is likely associated with the rapid ...

Invited Commentary: Zika Virus Infection and the Eye; Lee M. Jampol, MD; Debra A. Goldstein, MD
Invited Commentary  FREE
Lee M. Jampol, MD; Debra A. Goldstein, MD

Human and insect travel between continents has resulted in the dissemination of previously remote infections to more populated parts of the world. West Nile virus apparently moved from Israel to New York, where it decimated bird populations, and subsequently moved across the United States, producing human neurologic disease ...

Malvina B. Eydelman, MD; Tieuvi Nguyen, PhD, RAC; J. Angelo Green, PhD, DABT

This Viewpoint reports on the US Food and Drug Administration’s commitment to promoting public health by facilitating the development of innovative medical devices.

Original Investigation  FREE
Michael E. Zegans, MD; Antonio DiGiandomenico, PhD; Kathryn Ray, MA; Amanda Naimie, BS; Ashley E. Keller, BS; C. Kendall Stover, PhD; Prajna Lalitha, MD; Muthiah Srinivasan, MD; Nisha R. Acharya, MD, MS; Thomas M. Lietman, MD
Includes: Supplemental Content

Importance  Bacterial virulence factors are increasingly recognized as important in the understanding of clinical infections.

Objective  To determine whether 2 potential virulence factors, in vitro biofilm formation and Psl exopolysaccharide (EPS) expression, influence clinical presentation or outcomes in Pseudomonas aeruginosa keratitis.

Design, Setting, and Participants  ...

Brief Report 
Gabriel Velez, BS; C. Nathaniel Roybal, MD, PhD; Diana Colgan, PhD; Stephen H. Tsang, MD, PhD; Alexander G. Bassuk, MD, PhD; Vinit B. Mahajan, MD, PhD
Includes: Supplemental Content

Importance  To better characterize posterior uveitis, vitreous samples from 15 patients were subjected to antibody arrays, and the expression levels of 200 human cytokines were evaluated. Expression was analyzed by 1-way analysis of variance (significance at P < .01), unsupervised cluster algorithm, and pathway analysis.

Observations  Unbiased ...

JAMA Ophthalmology Clinical Challenge 
Eric G. Feinstein, MD; Ketki Soin, MD; Jennifer I. Lim, MD

A young man presents with persistent, stable metamorphopsia in the left eye and was diagnosed as having idiopathic choroidal folds. What would you do next?

Ah Ran Cho, MD; Young Hee Yoon, MD

A woman in her 40s had sudden painless loss of vision in her left eye for 3 days. Fluorescein angiography revealed nonischemic central retinal vein occlusion of her left eye.

Original Investigation 
Tadamichi Akagi, MD, PhD; Eri Nakano, MD; Hideo Nakanishi, MD; Akihito Uji, MD; Nagahisa Yoshimura, MD

Importance  Although trabeculotomy is a glaucoma surgical procedure for modest intraocular pressure (IOP) reduction, some eyes exhibit very low IOP during the early postoperative period. To our knowledge, the reason and its effect have not been investigated.

Objectives  To investigate ciliochoroidal detachment (CCD) immediately after ab ...

Original Investigation 
Roomasa Channa, MD; Syed Nabeel Zafar, MBBS, MPH; Joseph K. Canner, MHS; R. Sterling Haring, DO, MPH; Eric B. Schneider, PhD; David S. Friedman, MD, MPH, PhD
Includes: Supplemental Content

Importance  Determining the epidemiology of eye-related emergency department (ED) visits on a national level can assist policymakers in appropriate allocation of resources.

Objective  To study ED visits related to ocular conditions for all age groups across the United States.

Design, Setting, and Participants  Nationally representative ...

Original Investigation 
Laura A. McClure, MSPH; D. Diane Zheng, MS; Byron L. Lam, MD; Stacey L. Tannenbaum, PhD; Charlotte E. Joslin, OD, PhD; Sonia Davis, DrPH; Daniel López-Cevallos, PhD; Marston E. Youngblood Jr, MPH; Zhu-Ming Zhang, MD; Claudia Pulido Chambers, BPh; David J. Lee, PhD
Includes: Supplemental Content

Importance  Regular ocular care is critical to early detection and prevention of eye disease and associated morbidity and mortality; however, there have been relatively few studies of ocular health care utilization among Hispanics/Latinos of diverse backgrounds.

Objective  To examine factors associated with ocular health care utilization ...

JAMA Ophthalmology Clinical Challenge 
Ido D. Fabian, MD; Caroline Thaung, FRCOphth, FRCPath, DPhil; Mandeep S. Sagoo, MB, PhD, FRCS(Edin), FRCOphth

A woman in her 20s who was in her first trimester of pregnancy and asymptomatic was referred to the ocular oncology clinic owing to an incidental finding of a suspicious choroidal lesion in the left eye. What would you do next?

Original Investigation 
Thomas S. Hwang, MD; Simon S. Gao, PhD; Liang Liu, MD; Andreas K. Lauer, MD; Steven T. Bailey, MD; Christina J. Flaxel, MD; David J. Wilson, MD; David Huang, MD, PhD; Yali Jia, PhD
Includes: Supplemental Content

Importance  Macular ischemia is a key feature of diabetic retinopathy (DR). Quantification of macular ischemia has potential as a biomarker for DR.

Objective  To assess the feasibility of automated quantification of capillary nonperfusion as a potential sign of macular ischemia using optical coherence tomography (OCT) angiography....

Invited Commentary: Optical Coherence Tomographic Angiography in Diabetic Macular Ischemia; Gabriel Coscas, MD; Marco Lupidi, MD; Florence Coscas, MD
Original Investigation 
Alison Flatau, PhD; Francisco Solano, MD; Sana Idrees, MD; Joan L. Jefferys, ScM; Peter Volpe, MS; Christopher Damion; Harry A. Quigley, MD
Includes: Supplemental Content

Importance  Eyes of patients with glaucoma may be damaged during sleep.

Objective  To measure strains in glaucoma eyes and control eyes produced by mechanical force or deformation of the eye from contact when one side of the face rests against a pillow.

Design, Setting, and Participants...

Brief Report 
Paolo S. Silva, MD; Jerry D. Cavallerano, OD, PhD; Nour Maya N. Haddad, MD, MS; Dorothy Tolls, OD; Komal Thakore, OD; Bina Patel, OD; Mina Sehizadeh, OD; Ann M. Tolson, BS; Jennifer K. Sun, MD, MPH; Lloyd Paul Aiello, MD, PhD

Importance  Ultrawide field imaging (UWFI) is increasingly being used in teleophthalmology settings. Given the greater area of the retina imaged, we evaluated the ability of UWFI vs nonmydriatic fundus photography (NMFP) to detect nondiabetic retinal findings in a teleophthalmology program.

Observation  We conducted a retrospective single-center ...

Invited Commentary 
Gabriel Coscas, MD; Marco Lupidi, MD; Florence Coscas, MD

The fovea is a highly specialized macular region with a unique microanatomy that represents the area of greatest visual acuity. The fovea mainly consists of different structures that are highly dependent on multilayered capillary plexa for metabolic exchanges. Perifoveal capillary arcade disruption, enlargement of the foveal avascular zone, ...

Enrico Heffler, MD, PhD; Giuseppe Picardi, MD; Maria Teresa Liuzzo, MD; Maria Provvidenza Pistorio, BSc; Nunzio Crimi, MD, PhD

This report describes 2 patients with vernal keratoconjunctivitis without concomitant asthma who underwent systemic treatment with omalizumab.

Andrew M. Williams, BA; W. Daniel Stamer, PhD; R. Rand Allingham, MD

This Viewpoint discusses the need to ameliorate the shortage of donor eyes and increase the quality of human tissues available for scientific inquiry.

Original Investigation 
Nicole T. M. Saksens, MD; Maartje J. Geerlings, MSc; Bjorn Bakker, BaSc; Tina Schick, MD; Mohamed R. Daha, PhD; Sascha Fauser, PhD; Camiel J. F. Boon, PhD; Eiko K. de Jong, PhD; Carel B. Hoyng, PhD; Anneke I. den Hollander, PhD
Includes: Supplemental Content

Importance  Rare variants in the complement genes CFH, CFI, C9, and C3 have been found to be highly associated with age-related macular degeneration (AMD); however, the effect on clinical characteristics and familial segregation by these variants is lacking.

Objectives  To determine the contribution ...

Original Investigation 
Jae H. Kang, ScD; Walter C. Willett, MD, DrPH; Bernard A. Rosner, PhD; Emmanuel Buys, PhD; Janey L. Wiggs, MD, PhD; Louis R. Pasquale, MD
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Nitric oxide signaling alterations in outflow facility and retinal blood flow autoregulation are implicated in primary open-angle glaucoma (POAG). Nitric oxide donation has emerged as a POAG therapeutic target. An exogenous source of nitric oxide is dietary nitrates.

Objective  To evaluate the association between dietary ...

JAMA Ophthalmology Clinical Challenge 
Eric Feinstein, MD; Mei Zhou, MD; Pete Setabutr, MD

A 31-year-old man presented with multiple bilateral neoplastic growths on his eyelids and palmar pits on both hands. What would you do next?

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