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 Showing 1-20 of 87 Articles
Original Investigation 
David R. P. Almeida, MD, MBA, PhD, FRCSC; Li Zhang, PhD; Eric K. Chin, MD; Robert F. Mullins, PhD; Murat Kucukevcilioglu, MD; D. Brice Critser, BS, CRA; Milan Sonka, PhD; Edwin M. Stone, MD, PhD; James C. Folk, MD; Michael D. Abràmoff, MD, PhD; Stephen R. Russell, MD
Includes: Supplemental Content

Importance  The effects of position on retinal and choroidal structure are absent from the literature yet may provide insights into disease states such as age-related macular degeneration (AMD).

Objective  To evaluate the effect of postural change on retinal and choroidal structures in healthy volunteers and patients ...

Original Investigation 
Gui-Shuang Ying, PhD; Graham E. Quinn, MD, MSCE; Kelly C. Wade, MD, PhD, MSCE; Michael X. Repka, MD, MBA; Agnieshka Baumritter, MS; Ebenezer Daniel, MBBS, MS, PhD; for the e-ROP Cooperative Group
Includes: Supplemental Content

Importance  Detection of treatment-requiring retinopathy of prematurity (ROP) involves serial eye examinations. An ROP prediction model using predictive factors could identify high-risk infants and reduce required eye examinations.

Objective  To determine predictive factors for the development of referral-warranted (RW) ROP.

Design, Setting, and Participants  This ...

Ji Ah Kim, MD; Eun Ji Lee, MD; Kyu Hyung Park, MD, PhD; Se Joon Woo, MD, PhD
Dexamethasone intravitreal implant (Ozurdex) is a rod-shaped biodegradable implant composed of polylactic co-glycolic acid (PLGA) and 0.7 mg of dexamethasone. It has been shown to be effective for macular edema due to uveitis, retinal vein occlusion, or diabetic retinopathy.1,2
Eva Lenassi, MBBS, PhD; Anthony G. Robson, PhD; Linda M. Luxon, MBBS, PhD; Maria Bitner-Glindzicz, MBBS, PhD; Andrew R. Webster, MBBS, MD(Res)
Patients with Usher syndrome typically have progressive visual impairment due to retinitis pigmentosa (RP) and varying levels of deafness with or without vestibular involvement. Usher syndrome type 2 is the most common of the 3 clinical subtypes that have been described; it is associated with RP, moderate to severe congenital ...
Ophthalmic Images 
Michael C. Brodsky, MD; Cameron F. Parsa, MD
Graphic Jump LocationA, Morning glory disc anomaly may be associated with ipsilateral carotid dysgenesis and moyamoya disease (Japanese for the “something hazy like a puff of cigarette smoke” appearance created by dilated collateral vessels on angiography). Absence of central retinal vasculature gives rise to compensatory collateralization of chorioretinal anastomoses (cilioretinal ...
Original Investigation 
Brian P. Marr, MD; David H. Abramson, MD; Gil’ad N. Cohen, MS; Matthew J. Williamson, MPH; Beryl McCormick, MD; Christopher A. Barker, MD

Importance  Adjunct treatments for conjunctival malignancies are needed when standard therapy provides limited benefits or fails.

Objective  To describe the results of patients with diffuse conjunctival neoplasms treated with radioactive phosphorus 32 (32P)–impregnated flexible film.

Design, Setting, and Participants  This retrospective case series ...

Original Investigation 
Joshua D. Stein, MD, MS; David Childers, MA; Shivani Gupta, MD, MPH; Nidhi Talwar, MA; Bin Nan, PhD; Brian J. Lee, MD; Terry J. Smith, MD; Raymond Douglas, MD, PhD
Includes: Supplemental Content

Importance  Thyroid-associated ophthalmopathy (TAO) is a common and debilitating manifestation of Graves disease (GD). Presently little is known about factors that may increase the risk of developing TAO among patients with GD.

Objective  To identify risk factors associated with the development of TAO among individuals with ...

Original Investigation 
Barbara E. K. Klein, MD, MPH; Chelsea E. Myers, MStat; Kerri P. Howard, MS; Ronald Klein, MD, MPH
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Total serum and high-density lipoprotein cholesterol have been considered risk factors for severe vascular outcomes in persons with type 1 diabetes mellitus.

Objective  To examine the long-term relationships between these 2 serum lipids and the incidence and prevalence of proliferative diabetic retinopathy and macular edema....

Ophthalmic Images 
Yasser M. Elshatory, MD, PhD; Vinay A. Shah, MD
Graphic Jump LocationAn 11-year-old child experienced blurred vision of the left eye after a Bead Block (size range, 100-300 μm) embolization procedure to debulk a maxillary tumor. A, Fundus photograph. B, Early-phase fluorescein angiography showed an arteriolar occlusion with a visible round gray embolus. Visual acuity stabilized to 20/100. C, ...
Wendell J. Scott, MD; Norbert Schrage, MD; Claes Dohlman, MD, PhD
Rinsing eyes that have been exposed to chemicals as quickly as possible is still an indisputably sound practice. However, as ophthalmologists know, even prolonged postburn lavage is often unable to prevent visually impairing damage to the cornea, a situation that is rarely reparable with keratoplasty.1 In addition, glaucoma and optic ...
Original Investigation 
Bo Li, MD; Anne-Marie Powell, RN; Philip L. Hooper, MD; Thomas G. Sheidow, MD

Importance  Teleophthalmology has the potential to reduce costs and inconveniences associated with frequent patient visits. Evaluating teleophthalmology in the management of age-related macular degeneration (AMD) will allow for future implementation of this technology.

Objective  To evaluate teleophthalmology as a tool for the screening and monitoring of ...

Ambika Hoguet, MD; Richard K. Parrish II, MD
Anti–vascular endothelial growth factor (VEGF) agents are used for the treatment of neovascular age-related macular degeneration (AMD). These agents may also affect wound healing and decrease bleb vascularity after trabeculectomy.1 We are not aware of any reports of the effects of anti-VEGF agents on wound healing after glaucoma drainage implant ...
Comment & Response 
Anand Vinekar, MD, FRCS; Chaitra Jayadev, MD; Noel Bauer, MD, PhD
To the Editor We appreciate the results of the e-ROP Study evaluating telemedicine to detect severe (referral-warranted) retinopathy of prematurity (ROP).1
Comment & Response 
Mark Walland, FRANZCO, FRACS
To the Editor I was intrigued to read the case of trauma-induced prepapillary arterial loop torsion producing retinal arterial occlusion in a young person, but will politely contest the authors’ claim that this is the first such report.1
Comment & Response 
Graham E. Quinn, MD, MSCE; for the e-ROP Cooperative Group
In Reply We thank Vinekar and colleagues for their comments on our project and also for providing more details about KIDROP, which represents an important addition to the effort to provide ROP detection for premature infants. One point that needs to be made in response about our study is that ...
Comment & Response 
Ehsan Rahimy, MD; Nadim Rayess, MD; Richard S. Kaiser, MD
In Reply We thank Dr Walland for his interest and comments regarding our article.1 Dr Walland correctly points out that his article from 1993 presented a similar case of a young patient with prepapillary vascular loop and associated branch retinal arterial occlusion (BRAO) in the setting of antecedent head trauma.2 ...
Ophthalmic Images 
Michael L. Morgan, MD, PhD; Angelina Espino Barros Palau, MD; Tim Soeken, MS; Andrew G. Lee, MD
Graphic Jump LocationChiasmal glioma causing band cupping. Fundus photography shows optic atrophy in the right eye (A) and band cupping in the left eye (B) corresponding to generalized depression and temporal hemianopsia, respectively. C, Coronal T1-weighted postcontrast magnetic resonance imaging demonstrates the presumed chiasmal glioma, a minimally enhancing infiltrating mass. ...
Original Investigation 
Arun Narayanaswamy, MMed; Christopher K. Leung, FCOphth; Donny V. Istiantoro, SpM; Shamira A. Perera, FRCOphth; Ching-Lin Ho, FRCS(Ed); Monisha E. Nongpiur, MD; Mani Baskaran, DNB; Hla M. Htoon, PhD; Tina T. Wong, FRCOphth; David Goh, FRCOphth; Daniel H. Su, FRCS(Ed); Michael Belkin, MD; Tin Aung, FRCOphth
Includes: Supplemental Content

Importance  Selective laser trabeculoplasty (SLT) should be explored as a therapeutic option in eyes with angle closure.

Objective  To assess the intraocular pressure (IOP)–lowering efficacy of SLT in eyes with primary angle closure (PAC) and PAC glaucoma (PACG).

Design, Setting, and Participants  Randomized clinical trial ...

Original Investigation 
Hong-Peng Sun, PhD; Ang Li, BSc; Yong Xu, MSc; Chen-Wei Pan, MD, PhD

Importance  Understanding the burden and trends of reduced visual acuity (VA), a proxy measure for myopia, is essential to guide future health care and clinical management in China.

Objectives  To describe the secular trends from 1985 to 2010, correlate the prevalence of reduced VA among children ...

Original Investigation 
Hui-Chen Cheng, MD; Chao-Yu Guo, PhD; Mei-Ju Chen, MD; Yu-Chieh Ko, MD; Nicole Huang, PhD; Catherine Jui-ling Liu, MD
Includes: Supplemental Content

Importance  Previous studies have found that glaucoma is associated with impaired patient-reported vision-related quality of life (pVRQOL) but few, to our knowledge, have assessed how the visual field (VF) defect location impacts the pVRQOL.

Objective  To investigate the associations of VF defects in the superior vs ...

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