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 Showing 1-20 of 68 Articles
Original Investigation  FREE
Anthony J. King, MD, FRCOphth, MMedSci; Alan P. Rotchford, MD, FRCOphth

Importance  Establishing the true therapeutic effect of eyedrops when initiating glaucoma therapy is important. Accurate prediction of the intraocular pressure (IOP)–lowering response in the fellow eye when using a monocular trial eliminates the need for additional office visits to confirm the therapeutic effect.

Objective  To investigate ...

Original Investigation 
Elad Moisseiev, MD; Mark J. Mannis, MD

Importance  Low vision is irreversible in many patients and constitutes a disability. When no treatment to improve vision is available, technological developments aid these patients in their daily lives.

Objective  To evaluate the usefulness of a portable artificial vision device (OrCam) for patients with low vision....

Brief Report 
Nieraj Jain, MD; Yali Jia, PhD; Simon S. Gao, PhD; Xinbo Zhang, PhD; Richard G. Weleber, MD; David Huang, MD, PhD; Mark E. Pennesi, MD
Includes: Supplemental Content

Importance  Novel therapies for choroideremia, an X-linked recessive chorioretinal degeneration, demand a better understanding of the primary site(s) of cellular degeneration. Optical coherence tomography angiography allows for choriocapillaris (CC) imaging. We compared the extent of structural alterations of the CC, retinal pigment epithelium, and photoreceptors with multimodal ...

JAMA Ophthalmology Clinical Challenge 
Jonathan A. Micieli, MD, CM; Kay Lam, MD; Edward A. Margolin, MD

A woman in her 50s presented with painless bilateral vision loss that developed over a period of 2 weeks to the point that she was unable to appreciate light in either eye. What would you do next?

Katherine Boudreault, MD, FRCS; Sally Justus, BA; Winston Lee, MSc; Vinit B. Mahajan, MD, PhD; Stephen H. Tsang, MD, PhD

This case report describes a patient with central retinal artery occlusion following autologous bone marrow peribulbar stem cell injection for retinitis pigmentosa.

Tin Yan Alvin Liu, MD; Craig See, MD; Eric Singman, MD, PhD; Ian C. Han, MD

This case report describes acute vision loss from a lightning strike with delayed onset of cystoid macular abnormalities.

Comment & Response 
Christopher K. H. Burris, MD

To the Editor In response to the article by Koch et al titled “Extraocular Extension of a Benign Ciliary Body Nevus,”1 I would like to note that the slitlamp photograph as well as the ultrasound biomicroscopic image appear identical to the pigmented elevation often seen in Axenfeld ...

Comment & Response 
Konrad R. Koch, MD; Ludwig M. Heindl, MD

In Reply Dr Burris stated that the slitlamp photograph as well as the ultrasound biomicroscopic image presented by us1 appear identical to the pigmented elevation seen in Axenfeld nerve loops. Indeed, smaller pigmented episcleral lesions located within a 3- to 4-mm distance from the limbus, sometimes with ...

Original Investigation 
Vincent Daien, MD, PhD; Laurence Papinaud, MD; Mark C. Gillies, MBBS, PhD, FRANZCO; Caroline Domerg, MS; Nicolas Nagot, MD, PhD; Sandy Lacombe, MS; Jean Pierre Daures, MD, PhD; Isabelle Carriere, PhD; Max Villain, MD, PhD

Importance  Postoperative endophthalmitis (POE) often results in severe visual impairment. In clinical studies, an intracameral cefuroxime injection at the end of surgery was found to be effective at reducing the incidence of POE. Two important issues are the retinal safety of cefuroxime and its use for patients ...

Original Investigation 
Farzana Choudhury, MBBS, MS, PhD; Rohit Varma, MD, MPH; Ronald Klein, MD, MPH; W. James Gauderman, PhD; Stanley P. Azen, PhD; Roberta McKean-Cowdin, PhD; for the Los Angeles Latino Eye Study Group
Includes: Supplemental Content

Importance  This study found evidence of a threshold effect in which the presence of bilateral soft drusen and depigmentation of retinal pigment epithelium was associated with substantially low health-related quality of life (HRQoL) in adult Latinos from the United States.

Objective  To assess the association of ...

Invited Commentary: Patient-Reported Outcomes for Clinical Decision Making ; Päivi H. Miskala, PhD
Original Investigation 
Christina L. Decatur, BS; Erin Ong, BS, BA; Nisha Garg, BS; Hima Anbunathan, MS; Anne M. Bowcock, PhD; Matthew G. Field, MS; J. William Harbour, MD
Includes: Supplemental Content

Importance  Frequent mutations have been described in the following 5 genes in uveal melanoma (UM): BAP1, EIF1AX, GNA11, GNAQ, and SF3B1. Understanding the prognostic significance of these mutations could facilitate their use in precision medicine.

Objective  To determine the associations between ...

Invited Commentary: Prognostication of Uveal Melanoma; Arun D. Singh, MD
Original Investigation 
Scott D. Walter, MD; Daniel L. Chao, MD, PhD; William Feuer, MS; Joyce Schiffman, MS; Devron H. Char, MD; J. William Harbour, MD
Includes: Supplemental Content

Importance  Uveal melanoma (UM) can be divided into prognostically significant subgroups based on a prospectively validated and widely used 15-gene expression profile (GEP) test. Class 1 UMs have a low risk and class 2 UMs have a high risk for metastasis.

Objective  To determine whether any ...

Invited Commentary: Prognostication of Uveal Melanoma; Arun D. Singh, MD

The US Food and Drug Administration published a draft guidance document in 2006, which was finalized in 2009, that established the regulatory standards for development, validation, and use of patient-reported outcome (PRO) measures to support medical product–labeling claims regarding treatment benefit (ie, efficacy or comparative safety).1 The ...

Invited Commentary 
Arun D. Singh, MD

In this issue of JAMA Ophthalmology, 2 articles1,2 address important aspects of melanoma: pathogenesis (driver mutations), prognostication, and survival. Genetic alterations detected in the primary tumor by chromosomal tests (fluorescence in situ hybridization), DNA-based tests (single-nucleotide polymorphism and multiplex ligation–dependent probe amplification), and RNA-based ...

JAMA Ophthalmology Clinical Challenge 
Landon C. Meekins, MD; Pradeep Mettu, MD; M. Tariq Bhatti, MD

A man in his 20s presents with decreased vision in the left eye that was associated with intermittent left orbital pain that does not improve with 2 weeks of oral corticosteroids. What would you do next?

Thomas A. Eldredge, MBBS; Saul N. Rajak, PhD, FRCOphth; Ajay Taranath, MBBS, MD , FRANZCR; Dinesh Selva, MBBS, FRANZCO

This report describes a case of proptosis secondary to remodeling of the orbital bones in a patient with intracranial hypertension from acute lymphoblastic leukemia.

Original Investigation 
Hassan A. Aziz, MD; Nakul Singh, MS; James Bena, MS; Allan Wilkinson, PhD; Arun D. Singh, MD
Includes: Supplemental Content

Importance  Vision loss following episcleral brachytherapy for uveal melanoma is difficult to predict for individual patients.

Objective  To generate a risk calculator for vision loss following episcleral brachytherapy for uveal melanoma.

Design, Setting, and Participants  A retrospective review of data was conducted at a multispecialty ...

Original Investigation 
Ashvini K. Reddy, MD; Gregory W. Bounds, BS; Sophie J. Bakri, MD; Lynn K. Gordon, MD, PhD; Justine R. Smith, FRANZCO, PhD; Julia A. Haller, MD; Jennifer E. Thorne, MD, PhD

Importance  Women in ophthalmology are growing in number and have made strides in traditional metrics of professional achievement. Professional ties to industry represent another potential means of career advancement, recognition, and income.

Objective  To report the representation of women among ophthalmologists receiving industry remuneration for research, ...

Original Investigation 
Maureen G. Maguire, PhD; Gui-shuang Ying, PhD; Glenn J. Jaffe, MD; Cynthia A. Toth, MD; Ebenezer Daniel, MBBS, PhD; Juan Grunwald, MD; Daniel F. Martin, MD; Stephanie A. Hagstrom, PhD; for the CATT Research Group
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Single-nucleotide polymorphisms (SNPs) associated with the CFH, ARMS2, C3, LIPC, CFB, and C2 genes are associated with age-related macular degeneration (AMD); however, the association of these SNPs with angiographic features of neovascular AMD has been inconsistent in previous studies, and to ...

Invited Commentary 
Itay Chowers, MD

Age-related macular degeneration (AMD) is a multifactorial disease with a strong genetic basis. In recent years, the study of AMD genetics experienced a major advance; as a result, variants in more than 30 genes have been associated with AMD. It has been estimated that genetics contribute at least ...

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