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 Showing 1-20 of 77 Articles
Original Investigation 
Craig Ross, MBBS; Surinder Singh Pandav, MBBS, MS; Yu Qin Li, MBBS; Dan Q. Nguyen, MBChB, FRCOphth, FRANZCO; Stephen Beirne, PhD; Gordon G. Wallace, PhD, DSc; Tarek Shaarawy, MD, MSc; Jonathan G. Crowston, PHD, FRANZCO; Michael Coote, MBBS, FRANZCO
Includes: Supplemental Content

Importance  Control of intraocular pressure after implantation of a glaucoma drainage device (GDD) depends on the porosity of the capsule that forms around the plate of the GDD.

Objective  To compare capsular porosity after insertion of 2 different GDDs using a novel implant and measurement system....

Original Investigation 
Robert J. Campbell, MD, MSc; Sudeep S. Gill, MD, MSc; Martin ten Hove, MD, MEng; Sherif R. El-Defrawy, MD, PhD; Yi Ning J. Strube, MD, MS; Marlo Whitehead, MSc; Erica de L. P. Campbell, MD, MHA; Chaim M. Bell, MD, PhD

Importance  The growing complexity of medical and surgical care has resulted in increasing subspecialization. To date, data have been lacking regarding the degree to which subspecialization has affected the provision of strabismus surgical services. This gap is important to address given the implications for health care human ...

Original Investigation 
Anjali Parekh, MD; Sunil Srivastava, MD; James Bena, MS; Thomas Albini, MD; Quan Dong Nguyen, MD, MSc; Debra A. Goldstein, MD
Includes: Supplemental Content

Importance  Elevated intraocular pressure (IOP) is a well-known adverse event associated with the fluocinolone acetonide implant (FAI), but no data are available regarding factors associated with increased risk of IOP elevation in patients treated with the FAI.

Objective  To report risk factors that may predispose patients ...

Original Investigation 
Susan B. Bressler, MD; Talat Almukhtar, MBChB; Anjali Bhorade, MD; Neil M. Bressler, MD; Adam R. Glassman, MS; Suber S. Huang, MD; Lee M. Jampol, MD; Judy E. Kim, MD; Michele Melia, ScM; for the Diabetic Retinopathy Clinical Research Network Investigators

Importance  For the management of retinal disease, the use of intravitreous injections of anti–vascular endothelial growth factor has increased. Recent reports have suggested that this therapy may cause sustained elevation of intraocular pressure (IOP) and may potentially increase the risk of glaucoma for patients with retinal disease....

Joshua O. Mali, MD; Naomi S. Falk, MD; Yasmin P. Mali, MD; Laura Mencias, BS
We present a case of endogenous endophthalmitis involving only the anterior segment in the form of an iris abscess after a routine dental cleaning in an immunocompetent patient.
Original Investigation 
Yara T. E. Lechanteur, MD; Patrick L. van de Camp, MD; Dzenita Smailhodzic, MD, PhD; Johannes P. H. van de Ven, MD, PhD; Gabriëlle H. S. Buitendijk, MD, MSc; Caroline C. W. Klaver, MD, PhD; Joannes M. M. Groenewoud, MSc; Anneke I. den Hollander, PhD; Carel B. Hoyng, MD, PhD; B. Jeroen Klevering, MD, PhD

Importance  The age at which the first signs of age-related macular degeneration (AMD) manifest is variable. Better insight into factors that influence disease onset has direct implications for preventive measures and patient counseling.

Objective  To identify risk factors for an earlier age at onset of neovascular ...

Original Investigation 
Connie J. Chen, MD; Ian C. Han, MD; Jing Tian, MS; Beatriz Muñoz, MS; Morton F. Goldberg, MD
Includes: Supplemental Content

Importance  Extended follow-up of treated and untreated retinopathy in incontinentia pigmenti (IP) has not previously been documented, to our knowledge.

Objective  To determine which eyes with IP are at risk for retinal detachment.

Design, Setting, and Participants  Observational cohort study of patients with IP who ...

Research Letter 
David K. Wallace, MD, MPH; Elizabeth L. Lazar, MSPH; Earl R. Crouch III, MD; Darren L. Hoover, MD; Raymond T. Kraker, MSPH; Susanna M. Tamkins, OD; for the Pediatric Eye Disease Investigator Group
For children with amblyopia secondary to strabismus and/or anisometropia, many clinicians initiate treatment with spectacles alone, if needed.1,2 When improvement of the amblyopic eye stops after a period of treatment with spectacles alone, prescription of 2 hours of daily patching is often the next step.2,3 Our purpose was to evaluate ...
Tomas Ilginis, MBBS; Pearse A. Keane, MD, FRCOphth; Adnan Tufail, MD, FRCOphth
Includes: Supplemental Content
The retina receives blood from 2 sources. The outer retina is supplied by the choroid, whereas the inner retina is supplied by inner retinal capillaries in the superficial and deep plexuses. The fovea is perfused exclusively by the choroid. On optical coherence tomographic (OCT) imaging, novel reflectivity changes in the ...
Comment & Response 
Philip Lempert, MD
To the Editor The recent article by Repka et al1 concerning maintenance of visual acuity (VA) after treatment for amblyopia contains incongruities between the data and conclusions.
Comment & Response 
Michael X. Repka, MD, MBA; Raymond T. Kraker, MSPH; Jonathan M. Holmes, BM, BCh; for the Pediatric Eye Disease Investigator Group
In Reply Dr Lempert raises several issues, which we believe are mistaken or do not affect the interpretation of our results. As described,1 only participants at sites with more than 5 enrolled children were eligible for long-term follow-up for logistical reasons, which reduced the proportion of the original cohort that ...
Thomas J. Hwang, AB; Joseph B. Ciolino, MD
This Viewpoint discusses how innovative reimbursement pathways may impact the pace of ophthalmological research and development.
Original Investigation 
Suma P. Shankar, MD, PhD; David G. Birch, PhD; Richard S. Ruiz, MD; Dianna K. Hughbanks-Wheaton, PhD; Lori S. Sullivan, PhD; Sara J. Bowne, PhD; Edwin M. Stone, MD, PhD; Stephen P. Daiger, PhD

Importance  Screening for splice site mutation c.828+3A>T in the peripherin 2 (PRPH2) gene should be a high priority in families with highly variable retinal dystrophies. The correction of missplicing is a potential therapeutic target.

Objective  To determine the prevalence, genetic origin, and molecular mechanism ...

Original Investigation 
Gad Dotan, MD; Billy Truong, BS; Melanie Snitzer, MSW, LSW; Colleen McCauley, MPH; Sarah Martinez-Helfman, MS; Kathy Santa Maria, COT; Alex V. Levin, MD, MHSc

Importance  Low-socioeconomic urban children often do not have access to ophthalmic care.

Objective  To characterize the demographic characteristics and ophthalmic conditions in children attending Give Kids Sight Day (GKSD), an outreach ophthalmic care program held annually in Philadelphia, Pennsylvania, providing vision screening and immediate treatment when ...

Brief Report 
Jaitra P. Gowdar, DNB; Bindu Rajesh, MS; Anantharaman Giridhar, MS; Mahesh Gopalakrishnan, MS; Rameez Hussain, MS; Thomas Thachil, MS

Importance  Optic disc pit with associated maculopathy is a known entity. However, controversy exists regarding the source of subretinal fluid in these cases. In our series, we attempted to analyze the morphologic changes seen in the optic disc pit and evaluate the source of subretinal fluid.


Surgical Technique 
Juan B. Yepez, MD; J. Fernando Arevalo, MD
Includes: Supplemental Content
Uveal effusion syndrome (UES) was reported by Schepens and Brockhurst in 1963,1 and later described as a nanophthalmic disorder with a scleral abnormality.2 Gass3 described idiopathic UES and hypothesized that the cause was a congenital anomaly of the sclera and vortex veins that was related to aging, hormonal changes, or ...
Original Investigation 
Grace Huang, BS; Christina H. Fang, BS; Nitin Agarwal, MD; Neelakshi Bhagat, MD; Jean Anderson Eloy, MD; Paul D. Langer, MD

Importance  Patients are increasingly using the Internet to supplement finding medical information, which can be complex and requires a high level of reading comprehension. Online ophthalmologic materials from major ophthalmologic associations should be written at an appropriate reading level.

Objectives  To assess ophthalmologic online patient education ...

Original Investigation 
Christopher W. Noel, BSc; Henry Fung, BHSc; Raman Srivastava, MBT; Gerald Lebovic, PhD; Stephen W. Hwang, MD, MPH; Alan Berger, MD; Myrna Lichter, MD

Importance  The ocular status of homeless populations remains largely unknown. Given that visual acuity has been shown to be heavily correlated with reduced well-being and decreased earning potential, findings of poor vision could have important health implications for people experiencing homelessness.

Objectives  To assess the prevalence ...

Research Letter 
Lindsey B. De Lott, MD; James F. Burke, MD, MS; for the Michigan Neuro-Ophthalmology Research Consortium
Includes: Supplemental Content
Temporal artery biopsy (TAB) can confirm the diagnosis of giant cell arteritis (GCA), but it is not without risk.1 Therefore, markers of inflammation such as the erythrocyte sedimentation rate (ESR), C-reactive protein level (CRP), and platelet counts are often used to select patients for TAB.2- 4 Our aim was to ...
Frederick A. Jakobiec, MD, DSc; Anna M. Stagner, MD; Michael A. Nowak, MD; Peter A. D. Rubin, MD
Sebaceous carcinoma can arise in the meibomian glands of the eyelids and in the sebaceous glands of the eyelashes.1 Origination from the conjunctival epithelium is controversial in contrast to the sebaceous glands.2 We describe a de novo palpebral sebaceous carcinoma that did not display involvement of the tarsal meibomian glands. ...

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