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 Showing 1-20 of 69 Articles
Original Investigation  FREE
Antoine Rousseau, MD; Cecile Cauquil, MD; Benedicte Dupas, CO; Antoine Labbé, MD, PhD; Christophe Baudouin, MD, PhD; Emmanuel Barreau, MD; Marie Théaudin, MD, PhD; Catherine Lacroix, MD; Anne Guiochon-Mantel, MD, PhD; Anouar Benmalek, PhD; Marc Labetoulle, MD, PhD; David Adams, MD, PhD
Includes: Supplemental Content

Importance  Small fiber neuropathy (SFN) is an important feature of transthyretin familial amyloid polyneuropathy (TTR-FAP). A practical and objective method for the clinical evaluation of SFN is needed to improve the management of this disease. In vivo confocal microscopy (IVCM) of the corneal nerves, a rapid noninvasive ...

Invited Commentary: Confocal Microscopy of Corneal Nerves; Timo Tervo, MD, PhD; Juha Holopainen, MD, PhD; Carlos Belmonte, MD, PhD
Invited Commentary 
Timo Tervo, MD, PhD; Juha Holopainen, MD, PhD; Carlos Belmonte, MD, PhD

Small nerve fiber loss and damage, a neuropathy of the sensory and autonomic nervous systems, often appears after chemotherapy or develops following a number of genetic, degenerative, or metabolic diseases, with diabetes being its primary cause. Because of the different etiologies of small fiber neuropathy (SFN) and the ...

JAMA Ophthalmology Clinical Challenge 
Elad Moisseiev, MD; Lawrence S. Morse, MD, PhD

A man in his 40s who had previously undergone several treatments for diabetic macular edema without improving visual acuity past 20/70 OD had a fluocinolone acetonide intravitreal implant injected; soon after, the implant was seen in the middle of the vitreous cavity in a vertical orientation and in ...

Research Letter 
Rachel V. Thakore, BS; Paul B. Greenberg, MD; Jess J. Behrens, MS; Dustin D. French, PhD

This study compares the use of lower- vs higher-cost antivascular endothelial growth factor drugs prescribed for treatment of retinal vascular diseases in the Medicare population.

Farrah Islam, FCPS, FRCS; Sarah Hull, MA, FRCOphth; David C. Mansfield, PhD, FRCOphth; Anthony T. Moore, MA, FRCS, FRCOphth; Alan Bird, MD, FRCOphth

This case report describes a patient with a retinal vascular complex that most likely represents a developmental abnormality of the retinal vasculature, consistent with the role of von Hippel-Lindau disease in retinal vascular development.

Original Investigation 
Stanford C. Taylor, MD; Julia B. Huecker, MS; Mae O. Gordon, PhD; David E. Vollman, MD, MBA; Rajendra S. Apte, MD, PhD

Importance  The publication of the US Physician Payments Sunshine Act provides insight into the financial relationship between physicians and the pharmaceutical industry. This added transparency creates new opportunities of using objective data to better understand prior research that implicates pharmaceutical promotions as an important factor in a ...

Original Investigation 
Alon Skaat, MD; Michael S. Rosman, BA; Jason L. Chien, BS; Rachel S. Mogil, BS; Ruojin Ren, MD, PhD; Jeffrey M. Liebmann, MD; Robert Ritch, MD; Sung Chul Park, MD

Importance  The in vivo effect of pilocarpine hydrochloride on the Schlemm canal may help explain its pharmacologic mechanism of action and better indicate its clinical use.

Objective  To investigate the effect of pilocarpine on the structure of the Schlemm canal in vivo in healthy eyes and ...

Invited Commentary: Detailing Schlemm Canal Physiology; L. Jay Katz, MD

In this issue of JAMA Ophthalmology, Taylor et al1 have used the Centers for Medicare & Medicaid Services (CMS) Open Payments program 2013 database, which provides mandatory reporting data from companies on payments they make to physicians, and the CMS 2013 Provider Utilization and Payment Data: ...

Mysteries often are solved with the introduction of newer technology that reveals more information helping to answer lingering questions. Recently, for example, ground-penetrating radar using radiating electromagnetic pulses at the tomb of King Tutankhamun detected additional hidden rooms that may prove to be the long-lost burial chamber of ...

JAMA Ophthalmology Clinical Challenge 
Philip P. Storey, MD, MPH; Esther Lee Kim, MD; Vivek Patel, MD

An Asian woman in her 50s presented with ptosis, intermittent esotropia, and adduction deficit. She was presumed to have oculomotor nerve III damage and cranial nerve VI palsy. What would you do next?

Original Investigation 
Marissa L. Weber, MD; Michelle C. Liang, MD; Keith T. Flaherty, MD; Jeffrey S. Heier, MD
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  The use of mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitors has become more common in the treatment of systemic cancer. These agents have been associated with a central serous-like retinopathy in some patients. Recognition of such retinal findings and the relatively benign nature of these events ...

Original Investigation 
George M. Saleh, BSc, MBBS, FRCS, FRCOphth; James R. Wawrzynski, MA(Cantab), MB, BChir; Kamran Saha, MBBS; Phillip Smith, PhD; Declan Flanagan, FRCOphth; Melanie Hingorani, FCROphth; Clinton John, MSc; Paul Sullivan, FRCOphth

Importance  Human factors training can enhance teamworking and reduce error. It is used regularly in certain medical disciplines, but its use has not been established for ophthalmology to our knowledge.

Objective  To explore the feasibility of providing immersive simulation human factors training for ophthalmic surgical teams....

JAMA Ophthalmology Clinical Challenge 
Mohsin H. Ali, MD; Aisha S. Traish, MD

A man in his 30s presented with complaints of bilateral blurry vision, eye redness, and headaches. What would you do next?

Comment & Response 
Hugh R. Taylor, AC, MD, FRANZCO

To the Editor Boland et al1 examined frequency-doubling technology (FDT) perimetry to screen for glaucoma, but the study may lead to potentially misleading conclusions.

Comment & Response 
Michael V. Boland, MD, PhD; David S. Friedman, MD, PhD

In Reply We thank Dr Taylor for taking the time to comment on our evaluation of FDT perimetry as the sole means of screening for glaucoma using the National Health and Nutrition Examination Survey population.

Original Investigation 
Saif Baig, BS; Alberto Diniz-Filho, MD, PhD; Zhichao Wu, BAppSc(Optom), PhD; Ricardo Y. Abe, MD; Carolina P. B. Gracitelli, MD; Eric Cabezas, BS; Felipe A. Medeiros, MD, PhD
Includes: Supplemental Content

Importance  Patients with glaucoma and a history of fast visual field loss might be at an increased risk for falls compared with those with a history of slow visual field loss, but, to date, this association has not been previously investigated in the literature.

Objective  To ...

Invited Commentary: Visual Field Progression Velocity in Falls; Eva K. Fenwick, PhD; Ryan Eyn Kidd Man, PhD; Ecosse L. Lamoureux, PhD
Original Investigation 
Eric L. Ross, BA; David W. Hutton, PhD; Joshua D. Stein, MD, MS; Neil M. Bressler, MD; Lee M. Jampol, MD; Adam R. Glassman, MS; for the Diabetic Retinopathy Clinical Research Network
Includes: Supplemental Content

Importance  Anti–vascular endothelial growth factor (VEGF) medicines have revolutionized diabetic macular edema (DME) treatment. A recent randomized clinical trial comparing anti-VEGF agents for patients with decreased vision from DME found that at 1 year aflibercept (2.0 mg) achieved better visual outcomes than repackaged (compounded) bevacizumab (1.25 mg) ...

Brief Report 
Gavin Arno, PhD; Graham E. Holder, MSc, PhD; Christina Chakarova, PhD; Susanne Kohl, PhD; Nikolas Pontikos, PhD; Alessia Fiorentino, PhD; Vincent Plagnol, MSc, PhD; Michael E. Cheetham, PhD; Alison J. Hardcastle, PhD; Andrew R. Webster, MD(Res), FRCOphth; Michel Michaelides, MD(Res), FRCOphth; for the UK Inherited Retinal Disease Consortium
Includes: Supplemental Content

Importance  Mutations in phototransduction and retinal signaling genes are implicated in many retinopathies. To our knowledge, GNB3 encoding the G-protein β subunit 3 (Gβ3) has not previously been implicated in human disease.

Observations  In this brief report, whole-exome sequencing was conducted on a patient with distinct ...

Invited Commentary 
Eva K. Fenwick, PhD; Ryan Eyn Kidd Man, PhD; Ecosse L. Lamoureux, PhD

Falls in elderly individuals are relatively common and affect 1 in 3 community-living elderly adults annually. Of those who fall, 20% to 30% experience moderate to severe injuries, such as head or hip injuries. Serious falls are associated with increased morbidity and hospitalization and account for 70% of ...

JAMA Ophthalmology Clinical Challenge 
Saranya C. Balasubramaniam, MD; John J. Chen, MD, PhD

A woman in her 60s had a chronic progressive left homonymous visual field defect. What would you do next?

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