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 Showing 1-20 of 99 Articles
Original Investigation 
Arun Narayanaswamy, MMed; Christopher K. Leung, FCOphth; Donny V. Istiantoro, SpM; Shamira A. Perera, FRCOphth; Ching-Lin Ho, FRCS(Ed); Monisha E. Nongpiur, MD; Mani Baskaran, DNB; Hla M. Htoon, PhD; Tina T. Wong, FRCOphth; David Goh, FRCOphth; Daniel H. Su, FRCS(Ed); Michael Belkin, MD; Tin Aung, FRCOphth
Includes: Supplemental Content

Importance  Selective laser trabeculoplasty (SLT) should be explored as a therapeutic option in eyes with angle closure.

Objective  To assess the intraocular pressure (IOP)–lowering efficacy of SLT in eyes with primary angle closure (PAC) and PAC glaucoma (PACG).

Design, Setting, and Participants  Randomized clinical trial ...

Original Investigation 
Hong-Peng Sun, PhD; Ang Li, BSc; Yong Xu, MSc; Chen-Wei Pan, MD, PhD

Importance  Understanding the burden and trends of reduced visual acuity (VA), a proxy measure for myopia, is essential to guide future health care and clinical management in China.

Objectives  To describe the secular trends from 1985 to 2010, correlate the prevalence of reduced VA among children ...

Original Investigation 
Hui-Chen Cheng, MD; Chao-Yu Guo, PhD; Mei-Ju Chen, MD; Yu-Chieh Ko, MD; Nicole Huang, PhD; Catherine Jui-ling Liu, MD
Includes: Supplemental Content

Importance  Previous studies have found that glaucoma is associated with impaired patient-reported vision-related quality of life (pVRQOL) but few, to our knowledge, have assessed how the visual field (VF) defect location impacts the pVRQOL.

Objective  To investigate the associations of VF defects in the superior vs ...

To the Editor In 2012, Martin et al1 published the results at 2 years of the Comparison of Age-Related Macular Degeneration Treatments Trials and found a nonsignificant difference between bevacizumab and ranibizumab according to the continuous end point of the change in letters of visual acuity (mean difference for bevacizumab ...
Comment & Response 
Wenmin Sun, MD, PhD; Qingjiong Zhang, MD, PhD
To the Editor We read with interest the article titled “Mutation in TMEM98 in a Large White Kindred With Autosomal Dominant Nanophthalmos Linked to 17p12-q12” by Awadalla et al.1 The authors described a novel variant (c.577G>C, p.A193P) in TMEM98 that is associated with autosomal dominant nanophthalmos in a large family. ...
Comment & Response 
Mona S. Awadalla, MBBS, PhD; Kathryn P. Burdon, PhD; Jamie E. Craig, MBBS, DPhil, FRANZCO
In Reply We agree with Sun and Zhang that the association of TMEM98 with nanophthalmos1 requires further confirmation, ideally by identifying additional pathogenic mutations in families who have nanophthalmos with a similar phenotype combined with molecular evidence of gene dysfunction. However, the identification of variants in individuals with different phenotypes ...
Ophthalmic Images 
Johnathan D. Warminski, MD; Eduardo Uchiyama, MD
Graphic Jump LocationA 17-year-old adolescent boy presented with blurred vision for several weeks. Indirect ophthalmoscopy revealed dilated and tortuous vessels with diffuse retinal infiltrates and intraretinal hemorrhages as well as a macular leukemic infiltrate. Visual acuity was 20/400 OD and 20/20 OS, the white blood cell count was 521 400 ...
Original Investigation 
Teresa Borrás, PhD; LaKisha K. Buie, BS; Maria-Grazia Spiga, PhD; Juan Carabana, PhD
Includes: Supplemental Content

Importance  We developed a gene transfer tool for the control of nocturnal elevated intraocular pressure (IOP).

Objective  To demonstrate that inhibiting the trabecular meshwork RhoA pathway by delivering a mutated, dominant-negative RhoA gene (dnRhoA) carried inside a long-expressing recombinant virus would reduce nocturnal elevated ...

Original Investigation 
Anjo Riemens, MD, PhD; Jacoline Bromberg, MD, PhD; Valerie Touitou, MD, PhD; Bianka Sobolewska, MD; Tom Missotten, MD; Seerp Baarsma, MD; Carel Hoyng, MD, PhD; Miguel Cordero-Coma, MD, PhD; Oren Tomkins-Netzer, MD, PhD; Anna Rozalski, MD; Ilknur Tugal-Tutkun, MD, PhD; Yan Guex-Crosier, MD, PhD; Leonoor I. Los, MD, PhD; Jan Geert Bollemeijer, MD; Andrew Nolan, MD, PhD; Joya Pawade, MD, PhD; Francois Willermain, MD, PhD; Bahram Bodaghi, MD, PhD; Ninette ten Dam-van Loon, MD; Andrew Dick, MD, PhD; Manfred Zierhut, MD, PhD; Susan Lightman, MD, PhD; Friederike Mackensen, MD, PhD; Alexandre Moulin, MD; Roel Erckens, MD, PhD; Barbara Wensing, MD, PhD; Phuc le Hoang, MD, PhD; Henk Lokhorst, MD, PhD; Aniki Rothova, MD, PhD
Includes: Supplemental Content

Importance  The best treatment option for primary vitreoretinal lymphoma (PVRL) without signs of central nervous system lymphoma (CNSL) involvement determined on magnetic resonance imaging or in cerebrospinal fluid is unknown.

Objective  To evaluate the outcomes of treatment regimens used for PVRL in the prevention of subsequent ...

Original Investigation 
Choeng Jirawison, MD; Michael Yen, BS; Prattana Leenasirimakul, MD; Jenny Chen, MD; Siripim Guadanant, BA; Paradee Kunavisarut, MD; Direk Patikulsila, MD; Nawat Watanachai, MD; Somsanguan Ausayakhun, MD, MHSc; David Heiden, MD; Gary N. Holland, MD; Todd P. Margolis, MD, PhD; Jeremy D. Keenan, MD, MPH

Importance  Cytomegalovirus (CMV) retinitis is a leading cause of blindness in many developing countries, likely the result of inadequate screening. Telemedicine screening for CMV retinitis instituted at the point of care for human immunodeficiency virus (HIV) infection may allow for earlier detection.

Objectives  To determine the ...

Comment & Response 
Richard F. Spaide, MD
To the Editor I read with interest the article by Birnbaum et al titled “Correlation Between Clinical Signs and Optical Coherence Tomography With Enhanced Depth Imaging Findings in Patients With Birdshot Chorioretinopathy.”1 The authors examined 14 patients; we are told that 21 eye examinations were done in symptomatic patients, but ...
Comment & Response 
Andrea D. Birnbaum, MD, PhD; Amani A. Fawzi, MD; Debra A. Goldstein, MD
In Reply We thank Spaide for his critical review. He is correct in that data were included for each point at which complete data were available within the study period. Thus, more than 1 set of data points could be included for each patient. His main concern centers on the ...
Ophthalmic Images 
Yoshihiro Yonekawa, MD; Hana L. Takusagawa, MD; Shizuo Mukai, MD
Graphic Jump LocationA 4-month-old girl (born at 26 weeks’ gestation with a birth weight of 765 g) had vitreous and retinal hemorrhage (A), threshold retinopathy of prematurity (arrowheads) (B), epidural hemorrhages (arrowheads) (C), and long-bone fractures following abusive head trauma.
Original Investigation 
Valentina Franco-Cardenas, MD; Jamie Rosenberg, MD; Adriana Ramirez, MD; Juan Lin, PhD; Irena Tsui, MD

Importance  In recent decades, there has been an increase in the number of women practicing medicine. We believe this shift may be reaching academic publications in ophthalmology and changing gender trends.

Objective  To determine whether there has been an increase in women publishing academic articles and ...

Original Investigation 
Helga D. Munch-Petersen, MD; Peter K. Rasmussen, MD, PhD; Sarah E. Coupland, MBBS, PhD; Bita Esmaeli, MD; Paul T. Finger, MD; Gerardo F. Graue, MD; Hans E. Grossniklaus, MD, MBA; Santosh G. Honavar, MD; Jwu Jin Khong, MBBS(Hons), MMed, FRANZCO; Penny A. McKelvie, MD, PhD; Kaustubh Mulay, DNB; Jan U. Prause, MD, DMSc; Elisabeth Ralfkiaer, MD, DMSc; Lene D. Sjö, MD, PhD; Matthew C. Sniegowski, MD; Geeta K. Vemuganti, MD; Steffen Heegaard, MD, DMSc
Includes: Supplemental Content

Importance  The clinical features of diffuse large B-cell lymphoma (DLBCL) subtype of ocular adnexal lymphoma have not previously been evaluated in a large cohort to our knowledge.

Objective  To investigate the clinical features of ocular adnexal DLBCL (OA-DLBCL).

Design, Setting, and Participants  This retrospective international ...

Original Investigation 
Cynthia Owsley, PhD; Gerald McGwin Jr, PhD; David J. Lee, PhD; Byron L. Lam, MD; David S. Friedman, MD, PhD; Emily W. Gower, PhD; Julia A. Haller, MD; Lisa A. Hark, PhD; Jinan Saaddine, MD; for the Innovative Network for Sight (INSIGHT) Research Group
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  The use of a nonmydriatic camera for retinal imaging combined with the remote evaluation of images at a telemedicine reading center has been advanced as a strategy for diabetic retinopathy (DR) screening, particularly among patients with diabetes mellitus from ethnic/racial minority populations with low utilization of ...

Invited Commentary 
Julia A. Haller, MD
If the state of affairs documented by Franco-Cardenas and colleagues in their article1 on women’s authorship in the “big 3” ophthalmic publications continues—and their survey suggests no reason to believe otherwise—this 1 opinion piece increases by 20% the count of female-penned editorials in all 3 of our highest-impact ophthalmology journals ...
Comment & Response 
Richard F. Spaide, MD
To the Editor I read with interest the article titled “Progressive Outer Retinal Necrosis (PORN): A Catchy Acronym But Is the Anatomy Correct? The Salient Observation of Lorenz E. Zimmerman, MD.”1 In 1996, my colleagues and I reported the first series of patients, to our knowledge, with the diagnosis of ...
Comment & Response 
Rajesh Ramanjulu, MD, DNB, FVR, FAICO(VR); Mahesh Shanmugam Palanivelu, FRCSEd, DO, FRCS(Edin), PhD
To the Editor We read the article by Ghassemi et al1 about the combination treatment with intravitreal melphalan hydrochloride and topotecan hydrochloride for resistant vitreous seeds with great interest. The 3 main practical concerns regarding the rationale for this therapy include the following: (1) the primary question, ie, does the ...
Comment & Response 
Curtis E. Margo, MD, MPH; Scott M. Friedman, MD
In Reply Spaide questions why we selected the case report of PORN by Greven et al1 as a key reference when the association with varicella-zoster virus infection was established by polymerase chain reaction and not by light or electron microscopic localization of viral inclusions or capsids. First, we believe the ...

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