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 Showing 1-20 of 60 Articles
Malvina B. Eydelman, MD; Anindita Saha, BSE; Michelle E. Tarver, MD, PhD

This Viewpoint describes the role of the Center for Devices and Radiological Health of the Food and Drug Administration and its use of external scientific and clinical expertise.

Original Investigation 
Lloyd Paul Aiello, MD, PhD; Allison R. Ayala, MS; Andrew N. Antoszyk, MD; Bambi Arnold-Bush, MPH; Carl Baker, MD; Neil M. Bressler, MD; Michael J. Elman, MD; Adam R. Glassman, MS; Lee M. Jampol, MD; Michele Melia, ScM; Jared Nielsen, MD; Howard A. Wolpert, MD; for the Diabetic Retinopathy Clinical Research Network
Includes: Supplemental Content

Importance  Optimization of glycemic control is critical to reduce the number of diabetes mellitus–related complications, but long-term success is challenging. Although vision loss is among the greatest fears of individuals with diabetes, comprehensive personalized diabetes education and risk assessments are not consistently used in ophthalmologic settings.


Original Investigation 
Marco Antonio Bonini Filho, MD, PhD; Talisa E. de Carlo, BS; Daniela Ferrara, MD, PhD; Mehreen Adhi, MD; Caroline R. Baumal, MD; Andre J. Witkin, MD; Elias Reichel, MD; Jay S. Duker, MD; Nadia K. Waheed, MD, MPH

Importance  Choroidal neovascularization (CNV) is a major cause of vision loss in chronic central serous chorioretinopathy (CSCR). Detecting CNV using fluorescein angiography (FA) may be challenging owing to the coexistence of features related to the primary diagnosis of CSCR. Optical coherence tomography angiography (OCTA) allows noninvasive visualization ...

Original Investigation  FREE
Sharon F. Freedman, MD; Michael J. Lynn, MS; Allen D. Beck, MD; Erick D. Bothun, MD; Faruk H. Örge, MD; Scott R. Lambert, MD; for the Infant Aphakia Treatment Study Group
Includes: Supplemental Content

Importance  Glaucoma-related adverse events constitute major sight-threatening complications of cataract removal in infancy, yet their relationship to aphakia vs primary intraocular lens (IOL) implantation remains unsettled.

Objective  To identify and characterize cases of glaucoma and glaucoma-related adverse events (glaucoma + glaucoma suspect) among children in the Infant Aphakia ...

Brief Report 
Michel Paques, MD, PhD; Aurélie Brolly, MD; Jonathan Benesty, MD, PhD; Nicolas Lermé, PhD; Edouard Koch, MD, PhD; Florence Rossant, PhD; Isabelle Bloch, PhD; Jean-François Girmens, MD
Includes: Supplemental Content

Importance  Arteriovenous nickings (AVNs) in the retina are the cause of retinal vein occlusions and are also surrogates of cerebrovascular aging. The prevalent mechanistic model of AVNs stating that arteries crush veins remains somewhat unchallenged despite the lack of evidence other than fundus photographs. Here, we observed ...

Alice L. Williams, MD; Margaret Greven, MD; Samuel K. Houston, MD; Sonia Mehta, MD

Inadvertent compression of ocular tissues is an exceedingly rare cause of vision loss. Herein, we describe the second reported case, to our knowledge, of a self-induced orbital compression syndrome and the first set of images obtained with optical coherence tomography and fluorescein angiography in this condition.

Original Investigation  FREE
Scott F. McClellan, MD, MPH; Uri Soiberman, MD; Peter L. Gehlbach, MD, PhD; Peter N. Murakami, ScM; Walter J. Stark, MD
Includes: Supplemental Content

Importance  We have developed a novel surgical technique, to our knowledge, for the management of subluxated crystalline lenses involving preplacement of an iris-sutured posterior chamber intraocular lens (PCIOL) before pars plana vitrectomy and lensectomy.

Objective  To investigate the outcomes of eyes with subluxated crystalline lenses, predominantly ...

Original Investigation 
Mani Baskaran, DNB; Reuben C. Foo, MBBS; Ching-Yu Cheng, MD, PhD; Arun K. Narayanaswamy, DNB, MMed; Ying-Feng Zheng, MD, PhD; Renyi Wu, MD, PhD; Seang-Mei Saw, PhD; Paul J. Foster, PhD, FRCS(Ed); Tien-Yin Wong, MD, PhD; Tin Aung, PhD, FRCOphth
Includes: Supplemental Content

Importance  Glaucoma represents a major public health challenge in an aging population. The Tanjong Pagar Eye Study reported the prevalence and risk factors of glaucoma in a Singapore Chinese population in 1997, which established the higher rates of blindness in this population.

Objectives  To determine the ...

Original Investigation 
Mrinali P. Gupta, MD; Anne Marie Lane, MPH; Margaret M. DeAngelis, PhD; Katie Mayne, BS; Margaux Crabtree, MPH; Evangelos S. Gragoudas, MD; Ivana K. Kim, MD
Includes: Supplemental Content

Importance  Somatic mutations in BAP1 (BRCA1-associated protein 1 gene) are frequently identified in uveal melanoma. To date, the role of germline BAP1 mutations in uveal melanoma has not been characterized.

Objective  To characterize the clinical phenotype of uveal melanoma in patients with germline BAP1 mutations.

Design, ...

Dimosthenis Mantopoulos, MD; Kari L. Kendra, MD, PhD; Alan D. Letson, MD; Colleen M. Cebulla, MD, PhD

Several immune-related toxic effects have been reported with ipilimumab therapy for cutaneous melanoma. We describe a novel reaction, to our knowledge, involving the choroidal vasculature and resulting in bilateral serous retinal detachments without overt inflammatory signs.

Original Investigation 
Salma H. Radwan, MD; Ahmed Z. Soliman, MD; Julian Tokarev, BSc; Lei Zhang, MS; Frederik J. van Kuijk, MD, PhD; Dara D. Koozekanani, MD, PhD
Includes: Supplemental Content

Importance  Macular edema (ME) prognosis and treatment response vary according to the underlying abnormalities. Biomarkers of visual acuity (VA) improvement could influence management decisions in different types of ME.

Objective  To investigate whether disorganization of retinal inner layers (DRIL) and other spectral-domain optical coherence tomography (SD-OCT)–derived ...

Original Investigation 
Emmanuelle Souzeau, MSc; Melanie Hayes, PhD; Tiger Zhou, BMBS; Owen M. Siggs, PhD; Bronwyn Ridge, BA(Psych); Mona S. Awadalla, MBBS, PhD; James E. H. Smith, FRANZCO; Jonathan B. Ruddle, FRANZCO; James E. Elder, FRANZCO; David A. Mackey, MD, FRANZCO; Alex W. Hewitt, MBBS, PhD; Paul R. Healey, PhD, FRANZCO; Ivan Goldberg, FRANZCO; William H. Morgan, PhD, FRANZCO; John Landers, PhD, FRANZCO; Andrew Dubowsky, PhD; Kathryn P. Burdon, PhD; Jamie E. Craig, DPhil, FRANZCO
Includes: Supplemental Content

Importance  Juvenile open-angle glaucoma (JOAG) is a severe neurodegenerative eye disorder in which most of the genetic contribution remains unexplained.

Objective  To assess the prevalence of pathogenic CYP1B1 sequence variants in an Australian cohort of patients with JOAG and severe visual field loss.

Design, Setting, and ...

Original Investigation  FREE
Daniel Caldeira, MD; Mário Canastro, MD; Márcio Barra, MSc; Adriana Ferreira, MSc; João Costa, MD, PhD; Fausto J. Pinto, MD, PhD; Joaquim J. Ferreira, MD, PhD
Includes: Supplemental Content

Importance  In noninferiority trials, novel oral anticoagulants (NOACs), also known as non–vitamin K oral anticoagulants, were at least noninferior to standard care in the prevention of most prothrombotic conditions. However, differences exist in the safety profile of antithrombotic drugs, and little is known about their intraocular bleeding ...

To the Editor Demirci et al1 reported the successful treatment of a primary B-cell mucosa-associated lymphoid tissue (MALT) lymphoma of the iris with rituximab. The diagnosis was based on fine-needle aspiration (FNA) cytology findings described as “a monomorphic population of small to medium-sized hyperchromatic, CD20+ lymphocytes.”...

Comment & Response 
Hakan Demirci, MD; Victor M. Elner, MD, PhD

In Reply We thank Dr Margo for his comments concerning methods used to diagnose MALT lymphoma. The diagnosis of these lymphomas is usually made on the basis of morphology supported by immunohistochemical and flow cytometric studies. Polymerase chain reaction is rarely necessary. However, ophthalmic pathology biopsy specimens—particularly those ...

Original Investigation 
Florent Aptel, MD, PhD; Hafid Khayi, MD; Jean-Louis Pépin, MD, PhD; Renaud Tamisier, MD, PhD; Patrick Levy, MD, PhD; Jean-Paul Romanet, MD; Christophe Chiquet, MD, PhD
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  The prevalence of obstructive sleep apnea syndrome (OSAS) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) and its influence on second eye involvement is not well known.

Objective  To evaluate the prevalence of OSAS in patients with NAION and risk factors of second eye ...

Original Investigation 
Ana V. Torbidoni, PhD; Viviana E. Laurent, MSc; Claudia Sampor, MD; Daniela Ottaviani, BS; Valeria Vazquez, PhD; Mariano R. Gabri, PhD; Jorge Rossi, PhD; María T. de Dávila, MD, PhD; Cristina Alonso, PhD; Daniel F. Alonso, MD, PhD; Guillermo L. Chantada, MD, PhD

Importance  Disseminated retinoblastoma is usually fatal. Identification of small amounts (minimal dissemination [MD]) of tumor cells in extraocular sites might be a tool for designing appropriate treatments.

Objective  To test cone-rod homeobox (CRX) transcription factor as a lineage-specific molecular marker for metastatic retinoblastoma and for evaluation ...

Original Investigation 
Tobias Brockmann, MD; Claudia Brockmann, MD; Anna-Karina Maier, MD; Enken Gundlach, MD; Jan Schroeter, MD; Eckart Bertelmann, MD; Antonia M. Joussen, MD; Necip Torun, MD
Includes: Supplemental Content

Importance  The management of graft failure is increasingly relevant with the spread and growing acceptance of endothelial keratoplasty.

Objectives  To investigate the functional and anatomical results of secondary Descemet membrane endothelial keratoplasty (DMEK) for graft failure after Descemet stripping endothelial keratoplasty (DSEK) and to histologically analyze ...

Sayali Pradhan, MD, FICO; Manoranjan Das, MD; Arun Kumar Panigrahi, MD; N. Venkatesh Prajna, MD, FRCS

Corneal tattooing is considered to be a simple and safe outpatient procedure for unsightly leukomatous opacities. Very rarely, serious untoward complications may occur and may warrant additional medical and surgical management. We report a case of severe chemical injury following corneal tattooing and describe our strategy to treat ...

Comment & Response 
Christopher T. Leffler, MD, MPH; Adam C. Janot, MD

To the Editor Pineles et al1 studied binocular summation, defined as the improvement in visual acuity (VA) using binocular vision compared with the better eye alone. The authors reported that strabismus surgery was associated with average improvements in binocular summation of 0.8 letters for VA and of ...

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