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Clinical Sciences | May 23, 2013 
Plus Disease in Retinopathy of Prematurity:  Qualitative Analysis of Diagnostic Process by Experts
Nina J. Hewing, MD; David R. Kaufman, PhD; R. V. Paul Chan, MD; Michael F. Chiang, MD
Includes: Supplemental Content
ImportanceImportance Plus disease is the most important parameter that characterizes severe treatment-requiring retinopathy of prematurity, yet diagnostic agreement among experts is imperfect ...
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JAMA Ophthalmol. Published online May 23, 2013. doi:10.1001/jamaophthalmol.2013.135
Clinical Sciences | May 23, 2013 
Giant Conjunctival Nevus:  Clinical Features and Natural Course in 32 Cases
Carol L. Shields, MD; Audrey C. Regillo; Phoebe L. Mellen, BS; Swathi Kaliki, MD; Sara E. Lally, MD; Jerry A. Shields, MD
ImportanceImportance Conjunctival nevus is the most common tumor of the ocular surface and we selected the largest nevi to evaluate for clinical ...
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JAMA Ophthalmol. Published online May 23, 2013. doi:10.1001/jamaophthalmol.2013.160
Research Letters | May 23, 2013 
Oral Glucosamine Supplements as a Possible Ocular Hypertensive Agent
Ryan K. Murphy, DO, MA; Lecea Ketzler, DO; Robert D. E. Rice, MD; Sandra M. Johnson, MD; Mona S. Doss, MA; Edward H. Jaccoma, MD
The Centers for Disease Control and Prevention report that osteoarthritis affects 27 million adults in the United States. Glucosamine sulfate is a ...
JAMA Ophthalmol. Published online May 23, 2013. doi:10.1001/jamaophthalmol.2013.227
Research Letters | May 23, 2013 
Spectral-Domain Optical Coherence Tomographic Appearance of Acute Multifocal Retinitis
Yen Harn Yew, MD; Visvaraja Subrayan, FRCOphth, FRCS(Edin)
Acute multifocal retinitis, previously termed acute multifocal inner retinitis by Foster et al1 in 1991, is a very rare presentation of multiple ...
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JAMA Ophthalmol. Published online May 23, 2013. doi:10.1001/jamaophthalmol.2013.2489
Research Letters | May 23, 2013 
Progression of Diabetic Retinopathy in the Hypertension Intervention Nurse Telemedicine Study
Kelly W. Muir, MD, MHS; Janet Grubber, MSPH; Prithvi Mruthyunjaya, MD; Felicia McCant, MSSW; Hayden B. Bosworth, PhD
Interventions to improve glycemic control reduce the progression of diabetic retinopathy.1 Additionally, pharmacologic reduction of blood pressure (BP) in patients with diabetes ...
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JAMA Ophthalmol. Published online May 23, 2013. doi:10.1001/jamaophthalmol.2013.81
Clinical Sciences | May 16, 2013 
Phenotypic Conservation in Patients With X-Linked Retinitis Pigmentosa Caused by RPGR Mutations
Sarwar Zahid, MD, MS; Naheed Khan, PhD; Kari Branham, MS; Mohammad Othman, PhD; Athanasios J. Karoukis, BS; Nisha Sharma; Ashley Moncrief, BS; Mahdi N. Mahmood; Paul A. Sieving, MD, PhD; Anand Swaroop, PhD; John R. Heckenlively, MD; Thiran Jayasundera, MD
Includes: Supplemental Content
ImportanceImportance For patients with X-linked retinitis pigmentosa and clinicians alike, phenotypic variability can be challenging because it complicates counseling regarding patients' likely ...
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JAMA Ophthalmol. Published online May 16, 2013. doi:10.1001/jamaophthalmol.2013.120
Clinical Sciences | May 16, 2013 
Association of Ocular and Oculodermal Melanocytosis With the Rate of Uveal Melanoma Metastasis:  Analysis of 7872 Consecutive Eyes
Carol L. Shields, MD; Swathi Kaliki, MD; Michael Livesey, BS; Brianna Walker, BS; Robert Garoon, MD; Marissa Bucci, MD; Eric Feinstein, MD; Aline Pesch, BS; Cristina Gonzalez, MD; Sara E. Lally, MD; Arman Mashayekhi, MD; Jerry A. Shields, MD
ImportanceImportance Ocular/oculodermal (oculo[dermal]) melanocytosis is a congenital periocular pigmentary condition that can lead to the development of uveal melanoma, estimated at 1 ...
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JAMA Ophthalmol. Published online May 16, 2013. doi:10.1001/jamaophthalmol.2013.129
Small Case Series | May 16, 2013 
Intrachoroidal Cavitation in North Carolina Macular Dystrophy
Scott D. Schoenberger, MD; Anita Agarwal, MD
North Carolina macular dystrophy (NCMD) is an autosomal dominantly inherited condition with 3 phenotypic grades.1 Grade 1 has yellow or white drusenlike ...
JAMA Ophthalmol. Published online May 16, 2013. doi:10.1001/jamaophthalmol.2013.1598
Surgical Technique | May 16, 2013 
A Novel Technique of Modified Continuous Blanket Suture for Amniotic Membrane Fixation in Severe Ocular Surface Diseases
Zong-Duan Zhang, MD; Hui-Xiang Ma, MD; Ding Chen, MD, OD; Mei Li, MD; Jing-Bo Liu, MD; Fan Lu, MD, OD; Jia Qu, MD
The purpose of this article is to demonstrate a novel technique using modified continuous blanket suture (MCBS) to fix the amniotic membrane ...
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JAMA Ophthalmol. Published online May 16, 2013. doi:10.1001/jamaophthalmol.2013.2125
Special Article | May 16, 2013 
Paul A. Cibis, MD:  A Pioneer of Modern Vitreoretinal Surgery
Robert M. Feibel, MD; Christopher F. Blodi, MD
Paul Anton Cibis (1911-1965) was one of the pioneers of modern vitreoretinal surgery. He reasoned that the pathology of complex retinal detachments ...
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JAMA Ophthalmol. Published online May 16, 2013. doi:10.1001/jamaophthalmol.2013.597
Clinical Trials | May 9, 2013 
Reading Speed Improvements in Retinal Vein Occlusion After Ranibizumab Treatment
Ivan J. Suñer, MD; Neil M. Bressler, MD; Rohit Varma, MD; Paul Lee, MD; Chantal M. Dolan, PhD; James Ward, PhD; Shoshana Colman, PhD; Roman G. Rubio, MD
ImportanceImportance Treatment of macular edema secondary to retinal vein occlusion with ranibizumab has been shown to improve visual acuity compared with macular ...
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JAMA Ophthalmol. Published online May 09, 2013. doi:10.1001/jamaophthalmol.2013.114
Clinical Trials | May 9, 2013 
Treatment With 9- cis β-Carotene–Rich Powder in Patients With Retinitis Pigmentosa:  A Randomized Crossover Trial
Ygal Rotenstreich, MD; Michael Belkin, MD; Siegal Sadetzki, MD; Angela Chetrit, MSc; Gili Ferman-Attar, MD; Ifat Sher, PhD; Ayelet Harari, PhD; Aviv Shaish, PhD; Dror Harats, MD
Includes: Supplemental Content
ImportanceImportance Retinitis pigmentosa (RP) is the leading cause of incurable inherited blindness in the developed world, with an estimated prevalence of 1 ...
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JAMA Ophthalmol. Published online May 09, 2013. doi:10.1001/jamaophthalmol.2013.147
Editorial | May 9, 2013 
A Little Algae a Day Keeps the Retinal Degeneration Specialist Away?
Mark E. Pennesi, MD, PhD
Retinitis pigmentosa (RP) is a genetically heterogeneous inherited retinal degeneration that leads to slow but relentless vision loss, usually starting in the ...
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JAMA Ophthalmol. Published online May 09, 2013. doi:10.1001/jamaophthalmol.2013.4468
Special Article | May 9, 2013 
Jacques Guillemeau's 16th-Century Account of Ophthalmoplegia
M. Victoria Domínguez-Rodríguez, MA, PhD; Ayoze N. González-Hernández, MSc, MD
In 1585, the renowned French royal surgeon Jacques Guillemeau published his Traité des maladies de l’oeil. The book is divided into 9 ...
JAMA Ophthalmol. Published online May 09, 2013. doi:10.1001/jamaophthalmol.2013.596
Clinical Sciences | May 9, 2013 
Three Horizontal Muscle Surgery for Large-Angle Infantile or Presumed Infantile Esotropia:  Long-term Motor Outcomes
Klio I. Chatzistefanou, MD; Ioannis D. Ladas, MD; Konstantinos D. Droutsas, MD; Cryssanthi Koutsandrea, MD; Eleutheria Chimonidou, MD
ImportanceImportance Bilateral medial rectus muscle recession and one lateral rectus muscle resection surgery for the correction of large-angle infantile esotropia may be ...
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JAMA Ophthalmol. Published online May 09, 2013. doi:10.1001/jamaophthalmol.2013.704
Small Case Series | May 9, 2013 
Inadvertent Implantation of Aqueous Tube Shunts in Glaucomatous Eyes With Unrecognized Intraocular Neoplasms: Report of 5 Cases
Swathi Kaliki, MD; Ralph C. Eagle, MD; Hans E. Grossniklaus, MD; R. Jean Campbell, MD; Carol L. Shields, MD; Jerry A. Shields, MD
Intraocular tumors are a recognized cause of secondary glaucoma. Mechanisms of tumor-related glaucoma include direct tumor invasion or infiltration of the anterior ...
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JAMA Ophthalmol. Published online May 09, 2013. doi:10.1001/jamaophthalmol.2013.828
Clinical Trials | May 5, 2013 
Lutein/Zeaxanthin for the Treatment of Age-Related Cataract:  AREDS2 Randomized Trial Report No. 4
The Age-Related Eye Disease Study 2 (AREDS2) Research Group*
Includes: Supplemental Content
ImportanceImportance Age-related cataract is a leading cause of visual impairment in the United States. The prevalence of age-related cataract is increasing, with ...
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JAMA Ophthalmol. Published online May 05, 2013. doi:10.1001/jamaophthalmol.2013.4412
Small Case Series | May 2, 2013 
Intravitreal Fasudil Combined With Bevacizumab for Persistent Diabetic Macular Edema: A Novel Treatment
Hamid Ahmadieh, MD; Ramin Nourinia, MD; Ali Hafezi-Moghadam, MD, PhD
Despite recent advances in pharmacotherapy for diabetic macular edema (DME), satisfying anatomical and visual results are not always achieved. Improved understanding of ...
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JAMA Ophthalmol. Published online May 02, 2013. doi:10.1001/jamaophthalmol.2013.143
Small Case Series | May 2, 2013 
Varicella-Zoster Virus–Associated Multifocal Chorioretinitis in 2 Boys
Christina Meenken, MD, PhD; Aniki Rothova, MD, PhD
Varicella-zoster virus (VZV) may cause severe posterior eye segment inflammation and represents a major cause of the clinical syndrome called acute retinal ...
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JAMA Ophthalmol. Published online May 02, 2013. doi:10.1001/jamaophthalmol.2013.167
Small Case Series | May 2, 2013 
Management of Occult Necrotic Melanomas
Devron H. Char, MD; Tia B. Cole, MScPH; J. Brooks Crawford, MD
As many as 20% of uveal melanoma–containing eyes historically had opaque media and more than half of such tumors were unsuspected.1- 2 ...
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JAMA Ophthalmol. Published online May 02, 2013. doi:10.1001/jamaophthalmol.2013.231

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