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 Showing 1-20 of 65 Articles
Original Investigation  FREE
John A. Wells, MD; Adam R. Glassman, MS; Lee M. Jampol, MD; Lloyd Paul Aiello, MD, PhD; Andrew N. Antoszyk, MD; Carl W. Baker, MD; Neil M. Bressler, MD; David J. Browning, MD; Crystal G. Connor, MS, MPH; Michael J. Elman, MD; Frederick L. Ferris, MD; Scott M. Friedman, MD; Michele Melia, ScM; Dante J. Pieramici, MD; Jennifer K. Sun, MD, MPH; Roy W. Beck, MD, PhD; for the Diabetic Retinopathy Clinical Research Network
Includes: Supplemental Content

Importance  Comparisons of the relative effect of 3 anti–vascular endothelial growth factor agents to treat diabetic macular edema warrant further assessment.

Objective  To provide additional outcomes from a randomized trial evaluating 3 anti–vascular endothelial growth factor agents for diabetic macular edema within subgroups based on baseline ...

Original Investigation 
Zachary M. Bodnar, MD; Michael Neimkin, MD; John B. Holds, MD
Includes: Supplemental Content

Importance  Measurements of the margin reflex distances 1 and 2 are crucial for the surgical planning of ptosis repair and blepharoplasty. Facial photographs annotated with automated measurements of eyelid position could provide objective, accurate, and reproducible documentation of these features.

Objectives  To describe a software algorithm ...

Original Investigation 
Andrew Bastawrous, MBChB, BSc(Hons), FHEA, MRCOphth; Mario Ettore Giardini, PhD; Nigel M. Bolster, MEng; Tunde Peto, MD, PhD; Nisha Shah, MSc; Iain A. T. Livingstone, FRCOphth; Helen A. Weiss, PhD; Sen Hu, MSc; Hillary Rono, MBBS; Hannah Kuper, ScD; Matthew Burton, PhD, MA, MBBCh, MRCP, MRCOphth, DTM&H
Includes: Supplemental Content

Importance  Visualization and interpretation of the optic nerve and retina are essential parts of most physical examinations.

Objective  To design and validate a smartphone-based retinal adapter enabling image capture and remote grading of the retina.

Design, Setting, and Participants  This validation study compared the grading ...

Invited Commentary: Applicability of Smartphone-Based Screening Programs; Sunir J. Garg, MD
Invited Commentary 
Emily Y. Chew, MD

After decades of using focal/grid laser photocoagulation to reduce the risk of vision loss with diabetic macular edema (DME), the current therapy has shifted to intravitreal injections of anti–vascular endothelial growth factor (VEGF) agents, which can result in gains in visual acuity (VA). Investigators from the Diabetic Retinopathy ...

Invited Commentary 
Sunir J. Garg, MD

As a profession, we are fortunate to be able to obtain high-quality photographs of essentially all ocular structures and view them in high resolution nearly instantly. Rather than being luxuries, they are essential to the function of our office. The downside remains that each office has several hundred ...

Diana Katsman, MD, PhD; Michael A. Klufas, MD; David Sarraf, MD; SriniVas Sadda, MD

This case report describes retinal arterial tortuosity associated with moyamoya disease.

Jeffrey G. Gross, MD; Adam R. Glassman, MS

This Viewpoint discusses the Diabetic Retinopathy Clinical Research Network randomized trial comparing ranibizumab vs panretinal photocoagulation for proliferative diabetic retinopathy in eyes with or without diabetic macular edema.

Original Investigation 
Timothy L. Jackson, PhD, FRCOphth; Robert L. Johnston, FRCOphth; Paul H. J. Donachie, MSc; Tom H. Williamson, MD, FRCOphth; John M. Sparrow, DPhil, FRCOphth; David H. W. Steel, FRCOphth
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Patients and clinicians need to accurately assess the risks and benefits of pars plana vitrectomy for proliferative diabetic retinopathy, but clinical trial data may not reflect real-world experience.

Objective  To prospectively audit the complications of vitrectomy for proliferative diabetic retinopathy and help establish benchmarks.

Design, ...

Invited Commentary: Vitrectomy for Proliferative Diabetic Retinopathy; David J. Browning, MD, PhD

Importance  Preservation of vision in patients with diabetes mellitus is critical. Interventions to improve glycemic control through early intensive treatment of diabetes reduce rates of severe retinopathy and preserve visual acuity.

Objective  To assess the effects of prior intensive insulin treatment and risk factors on patient-reported ...

Original Investigation 
Neil M. Bressler, MD; Rohit Varma, MD; Paul Mitchell, MD; Ivan J. Suñer, MD; Chantal Dolan, PhD; James Ward, PhD; Alberto Ferreira, PhD, MBA; Jason S. Ehrlich, MD, PhD; Adam Turpcu, PhD
Includes: Supplemental Content

Importance  The potential effect of treatments for diabetic macular edema (DME) on driving should be of value to patients and clinicians, such as ophthalmologists and other physicians, who treat patients with diabetes mellitus.

Objective  To determine the effect of ranibizumab on driving and patient-reported vision function ...

Invited Commentary 
David J. Browning, MD, PhD

Assessing the quality of health care delivery has long interested ophthalmologists and guides discussions about informed consent, but with the increased use of electronic health records and the increased scrutiny by payers, more efforts have been devoted to the topic. Measuring quality is difficult, in part, because of ...

JAMA Ophthalmology Clinical Challenge 
Leonard G. Heydenrych, FCOphth (SA), FRCOphth; Nagib Du Toit, FRCS (Ed), MMed(UCT); David Le Feuvre, MMed (Neurosurg, UCT), MSc (Paris), FCS Neurosurg (SA)

A man in his 30s who had sustained a stab injury to his left orbit 15 years earlier was assessed for a proptotic left eye. The proptosis had a difference of 14 mm between eyes; the left eye had a palpable thrill, audible bruit, chemosis, dilated conjunctival blood ...

Comment & Response 
Marcus C. de Jong, MD, MSc; Arjenne Kors, MD; Pim de Graaf, MD, PhD

To the Editor Our team read with interest the article by Yannuzzi et al1 about enucleation vs ophthalmic artery chemosurgery (OAC) as primary treatment for advanced-stage retinoblastoma. This is an important article reviewing the outcome of patients who received OAC. We wonder whether their conclusions should have ...

Comment & Response 
Nicolas A. Yannuzzi, MD; Jasmine H. Francis, MD; David H. Abramson, MD

In Reply We thank De Jong and colleagues for their interest in our article and for their continued contributions to the field. We too recognize that new observations must always be viewed with caution. While the numbers may seem small (140 eyes), they represent the largest published series, ...

Original Investigation 
Michael V. Boland, MD, PhD; Priya Gupta, MD; Fang Ko, MD; Di Zhao, PhD; Eliseo Guallar, MD, DrPH; David S. Friedman, MD, PhD
Includes: Supplemental Content

Importance  Glaucoma is a significant cause of global blindness and there are, as yet, no effective means of screening.

Objective  To assess the potential role of frequency-doubling technology (FDT) perimetry in screening for glaucoma using data collected as part of the National Health and Nutrition Examination ...

Original Investigation 
John R. Economides, PhD; Daniel L. Adams, PhD; Jonathan C. Horton, MD, PhD

Importance  In strabismus, the fixating eye conveys the direction of gaze while the fellow eye points at a peripheral location in space. The stability of the eyes may be reduced by the absence of a common target.

Objective  To quantify the stability of eye position in ...

Original Investigation 
Marlen Parissi, MSc; Stefan Randjelovic, MSc; Enea Poletti, PhD; Pedro Guimarães, PhD; Alfredo Ruggeri, PhD; Sofia Fragkiskou, MD; Thu Ba Wihlmark, MD; Tor Paaske Utheim, MD, PhD; Neil Lagali, PhD
Includes: Supplemental Content

Importance  It is unknown whether a neurotrophic deficit or pathologic nerve morphology persists in keratoconus in the long term after corneal collagen cross-linking (CXL) treatment. Nerve pathology could impact long-term corneal status in patients with keratoconus.

Objective  To determine whether CXL treatment of keratoconus results in ...

Brief Report 
Marina Rodríguez-Calvo de Mora, MD; Esther A. Groeneveld-van Beek, MSc; Laurence E. Frank, PhD; Jacqueline van der Wees, PhD; Silke Oellerich, PhD; Marieke Bruinsma, PhD; Gerrit R. J. Melles, MD, PhD

Importance  After retrospectively evaluating the clinical outcome of 500 consecutive cases after Descemet membrane endothelial keratoplasty (DMEK), we extended the analysis in this study by assessing the effect of donor-related parameters on endothelial cell density (ECD) decline and detachment rate in this group.

Observations  This retrospective ...

Original Investigation 
Steven Holfinger, MD; Alexander G. Miller; Llewelyn J. Rao, MD; Douglas Y. Rowland, PhD; Joan H. Hornik, AB; David G. Miller, MD

Importance  Requirements regulating pharmaceutical prescriptions can affect physicians’ choice of therapy in a clinical setting.

Objective  To evaluate the change in bevacizumab use after the regulatory requirement for patient-specific prescriptions (PSPs) for off-label medications in Ohio.

Design, Setting, and Participants  This study retrospectively reviewed the ...

Original Investigation  FREE
Isabel Schuermeyer, MD; Anca Maican, MS; Richard Sharp, PhD; James Bena, MS; Pierre L. Triozzi, MD; Arun D. Singh, MD

Importance  To our knowledge, longitudinal assessment of depression, anxiety, and decision regret (a sense of disappointment or dissatisfaction in the decision) in patients undergoing prognostication for uveal melanoma does not exist.

Objective  To report on depression, anxiety, and decision regret before and after testing to estimate ...

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