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 Showing 1-20 of 63 Articles
Original Investigation 
Phillippa M. Cumberland, MSc; Jugnoo S. Rahi, PhD, FRCOphth; for the UK Biobank Eye and Vision Consortium
Includes: Supplemental Content

Importance  The adverse impact of visual impairment and blindness and correlations with socioeconomic position are known. Understanding of the effect of the substantially more common near-normal vision (mild impairment) and associations with social position as well as health and life chances is limited.

Objective  To investigate ...

Original Investigation 
Eva K. Fenwick, PhD; Peng Guan Ong, BSc(Hons); Ryan Eyn Kidd Man, PhD; Ching-Yu Cheng, PhD; Charumathi Sabanayagam, PhD; Tien Y. Wong, PhD; Ecosse L. Lamoureux, PhD

Importance  Mobility limitations arising from vision impairment (VI) can result in loss of independence and reduced quality of life. However, few data are available on the association between VI and mobility limitations at a population-based level, particularly in Asian populations.

Objective  To assess the association of ...

Invited Commentary: Visual Impairment and Mobility; Bonnielin K. Swenor, PhD, MPH
Original Investigation  FREE
Joshua D. Stein, MD, MS; Peter Y. Zhao, MD; Chris Andrews, PhD; Gregory L. Skuta, MD

Importance  Oklahoma is one of the few states where optometrists have surgical privileges to perform laser trabeculoplasty (LTP). Optometrists in other states are lobbying to obtain privileges to perform LTP and other laser procedures. Little is known whether outcomes of patients undergoing this procedure by optometrists are ...

Invited Commentary 
Murray Fingeret, OD

In the article by Stein et al,1 the authors’ stated objective was “To compare outcomes of LTPs [laser trabeculoplasties] performed by ophthalmologists with those performed by optometrists to determine whether differences exist in the need for additional LTPs.” However, the conclusions seem misleading and not supported by ...

Invited Commentary 
Alan L. Robin, MD

Laser trabeculoplasty (LTP) was popularized in 19791 in eyes receiving maximal medical therapy. Various prospective clinical trials sponsored by the National Institutes of Health have since better defined its usefulness in early and advanced glaucoma. Today, the American Academy of Ophthalmology Primary Open Angle Glaucoma Preferred Practice ...

Invited Commentary 
Bonnielin K. Swenor, PhD, MPH

As the number of older adults increases worldwide, the importance of understanding the global picture of older persons has been magnified. This perspective not only includes identifying the diseases and health conditions affecting older ages but also examining the effect of these conditions on everyday life. Over the ...

JAMA Ophthalmology Clinical Challenge 
Patrick J. Chiam, FRCOphth

A teenaged boy awakened 2 days prior to presentation with a few skin lesions, which rapidly spread to the rest of his right eyelids. Examination revealed clusters of target lesions on the right upper and lower lids, with papillae in the upper palpebral conjunctiva and follicles and a ...

Original Investigation 
Robert E. Wiggins Jr, MD, MHA; Rebecca Etz, PhD

Importance  There is disagreement as to whether Maintenance of Certification is creating value for physicians and their patients. To our knowledge, this report provides the first measures of the effectiveness of Part 4 of this activity in assisting ophthalmologists with quality improvement in their practices.

Objective  ...

Invited Commentary: The Value of Maintenance of Certification; Hilary A. Beaver, MD
Original Investigation 
Sayantan Biswas, MPhil; Chen Lin, BM; Christopher K. S. Leung, MD

Importance  Analysis of retinal nerve fiber layer (RNFL) abnormalities with optical coherence tomography in eyes with high myopia has been complicated by high rates of false-positive errors. An understanding of whether the application of a myopic normative database can improve the specificity for detection of RNFL abnormalities ...

Invited Commentary: Optical Coherence Tomography in High Myopia; Joel S. Schuman, MD
Original Investigation 
Susan Vitale, PhD, MHS; Traci E. Clemons, PhD; Elvira Agrón, MA; Frederick L. Ferris III, MD; Amitha Domalpally, MD; Ronald P. Danis, MD; Emily Y. Chew, MD; for the Age-Related Eye Disease Study 2 (AREDS2) Research Group
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  To test potential treatments for age-related macular degeneration (AMD), clinical trials need standardized outcome measures that are valid for predicting AMD progression in different study populations.

Objective  To evaluate the validity of the Age-Related Eye Disease Study (AREDS) detailed and simple AMD severity scales by ...

Invited Commentary: Use of the AREDS Severity Scale for Age-Related Macular Degeneration; Chui Ming Gemmy Cheung, FRCOphth; Tien Yin Wong, MBBS, PhD, FRCS(Ed)
Invited Commentary 
Hilary A. Beaver, MD

All physicians want to give their patients the best quality care and to believe that they themselves have kept abreast of new information and technology. All patients want to believe that their physicians are wise, learned, and up to date on the condition for which they are consulting. ...

Invited Commentary 
Joel S. Schuman, MD

Optical coherence tomography (OCT) is a precise technology that can be used for interrogating tissue structure and function noninvasively, painlessly, and quickly using near-infrared light. At its inception, OCT was typically a tool for assessing tissue thickness. Time-domain OCT is fast enough to scan a circle centered on ...

Invited Commentary 
Chui Ming Gemmy Cheung, FRCOphth; Tien Yin Wong, MBBS, PhD, FRCS(Ed)

Numerous population-based epidemiologic studies13 have reported on the prevalence, incidence, and risk factors of age-related macular degeneration (AMD) in the United States and globally. One such study1 suggests that 6% to 8% of adults 40 years and older have signs of early-stage AMD. However, ...

JAMA Ophthalmology Clinical Challenge 
Rajesh C. Rao, MD; J. William Harbour, MD

A woman in her 50s with an unremarkable medical history noticed a gradually enlarging, white-brown, circular lesion on her right iris over the past several years but denied visual changes. Slitlamp examination of the anterior segment showed a 2 mm × 2 mm circular iris lesion at the inferotemporal border ...

Original Investigation 
Imam M. Xierali, PhD; Marc A. Nivet, EdD; M. Roy Wilson, MD
Includes: Supplemental Content

Importance  Increasing the level of diversity among ophthalmologists may help reduce disparities in eye care.

Objective  To assess the current and future status of diversity among ophthalmologists in the workforce by sex, race, and ethnicity in the context of the available number of medical students in ...

Original Investigation 
Michael S. Deiner, PhD; Thomas M. Lietman, MD; Stephen D. McLeod, MD; James Chodosh, MD, MPH; Travis C. Porco, PhD, MPH
Includes: Supplemental Content

Importance  Internet-based search engine and social media data may provide a novel complementary source for better understanding the epidemiologic factors of infectious eye diseases, which could better inform eye health care and disease prevention.

Objective  To assess whether data from internet-based social media and search engines ...

Brief Report 
Soundaram MeenakshiSundaram, MD; Aalia Rasool Sufi, MD; N. Venkatesh Prajna, MD; Jeremy D. Keenan, MD, MPH

Importance  In vivo confocal microscopy could be useful in cases of fungal or acanthamoeba keratitis to determine the depth of infectious elements, but its accuracy in determining corneal thickness relative to more traditional techniques has not been well characterized.

Observations  In this cross-sectional observational case series, ...

Brief Report 
Livia Tomasso, MDs; Lucia Benatti, MD; Adriano Carnevali, MD; Andrea Mazzaferro, MDs; Giovanni Baldin, MDs; Lea Querques, MD; Francesco Bandello, MD, FEBO; Giuseppe Querques, MD, PhD

Importance  The aim of this study is to determine whether the cross-shaped fixation target in a spectral-domain optical coherence tomography instrument (Spectralis; Heidelberg Engineering) could produce a cross-shaped increase fundus autofluorescence artifact on subsequent imaging.

Observations  Thirty eyes of 15 healthy volunteers (8 women and 7 ...

Our new era of clinical practice is largely the consequence of profound advances in imaging, devices, and therapeutics. But 2 other developments, outside our traditional domain, are beginning to affect our ability to predict, prepare for, and treat disease: “big data” and social media. The influence that big ...

JAMA Ophthalmology Clinical Challenge 
Mohsin H. Ali, MD; Felix Y. Chau, MD; Javaneh Abbasian, MD

A 2-year-old African American boy with leukocoria in his left eye noted during a routine well-child visit was unable to read the distance chart, had an APD and a white-yellow mass in the macula OS. What would you do next?

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