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 Showing 1-20 of 92 Articles
Original Investigation 
Teresa Borrás, PhD; LaKisha K. Buie, BS; Maria-Grazia Spiga, PhD; Juan Carabana, PhD
Includes: Supplemental Content

Importance  We developed a gene transfer tool for the control of nocturnal elevated intraocular pressure (IOP).

Objective  To demonstrate that inhibiting the trabecular meshwork RhoA pathway by delivering a mutated, dominant-negative RhoA gene (dnRhoA) carried inside a long-expressing recombinant virus would reduce nocturnal elevated ...

Original Investigation 
Anjo Riemens, MD, PhD; Jacoline Bromberg, MD, PhD; Valerie Touitou, MD, PhD; Bianka Sobolewska, MD; Tom Missotten, MD; Seerp Baarsma, MD; Carel Hoyng, MD, PhD; Miguel Cordero-Coma, MD, PhD; Oren Tomkins-Netzer, MD, PhD; Anna Rozalski, MD; Ilknur Tugal-Tutkun, MD, PhD; Yan Guex-Crosier, MD, PhD; Leonoor I. Los, MD, PhD; Jan Geert Bollemeijer, MD; Andrew Nolan, MD, PhD; Joya Pawade, MD, PhD; Francois Willermain, MD, PhD; Bahram Bodaghi, MD, PhD; Ninette ten Dam-van Loon, MD; Andrew Dick, MD, PhD; Manfred Zierhut, MD, PhD; Susan Lightman, MD, PhD; Friederike Mackensen, MD, PhD; Alexandre Moulin, MD; Roel Erckens, MD, PhD; Barbara Wensing, MD, PhD; Phuc le Hoang, MD, PhD; Henk Lokhorst, MD, PhD; Aniki Rothova, MD, PhD
Includes: Supplemental Content

Importance  The best treatment option for primary vitreoretinal lymphoma (PVRL) without signs of central nervous system lymphoma (CNSL) involvement determined on magnetic resonance imaging or in cerebrospinal fluid is unknown.

Objective  To evaluate the outcomes of treatment regimens used for PVRL in the prevention of subsequent ...

Original Investigation 
Choeng Jirawison, MD; Michael Yen, BS; Prattana Leenasirimakul, MD; Jenny Chen, MD; Siripim Guadanant, BA; Paradee Kunavisarut, MD; Direk Patikulsila, MD; Nawat Watanachai, MD; Somsanguan Ausayakhun, MD, MHSc; David Heiden, MD; Gary N. Holland, MD; Todd P. Margolis, MD, PhD; Jeremy D. Keenan, MD, MPH

Importance  Cytomegalovirus (CMV) retinitis is a leading cause of blindness in many developing countries, likely the result of inadequate screening. Telemedicine screening for CMV retinitis instituted at the point of care for human immunodeficiency virus (HIV) infection may allow for earlier detection.

Objectives  To determine the ...

Comment & Response 
Richard F. Spaide, MD
To the Editor I read with interest the article by Birnbaum et al titled “Correlation Between Clinical Signs and Optical Coherence Tomography With Enhanced Depth Imaging Findings in Patients With Birdshot Chorioretinopathy.”1 The authors examined 14 patients; we are told that 21 eye examinations were done in symptomatic patients, but ...
Comment & Response 
Andrea D. Birnbaum, MD, PhD; Amani A. Fawzi, MD; Debra A. Goldstein, MD
In Reply We thank Spaide for his critical review. He is correct in that data were included for each point at which complete data were available within the study period. Thus, more than 1 set of data points could be included for each patient. His main concern centers on the ...
Ophthalmic Images 
Yoshihiro Yonekawa, MD; Hana L. Takusagawa, MD; Shizuo Mukai, MD
Graphic Jump LocationA 4-month-old girl (born at 26 weeks’ gestation with a birth weight of 765 g) had vitreous and retinal hemorrhage (A), threshold retinopathy of prematurity (arrowheads) (B), epidural hemorrhages (arrowheads) (C), and long-bone fractures following abusive head trauma.
Original Investigation 
Valentina Franco-Cardenas, MD; Jamie Rosenberg, MD; Adriana Ramirez, MD; Juan Lin, PhD; Irena Tsui, MD

Importance  In recent decades, there has been an increase in the number of women practicing medicine. We believe this shift may be reaching academic publications in ophthalmology and changing gender trends.

Objective  To determine whether there has been an increase in women publishing academic articles and ...

Original Investigation 
Helga D. Munch-Petersen, MD; Peter K. Rasmussen, MD, PhD; Sarah E. Coupland, MBBS, PhD; Bita Esmaeli, MD; Paul T. Finger, MD; Gerardo F. Graue, MD; Hans E. Grossniklaus, MD, MBA; Santosh G. Honavar, MD; Jwu Jin Khong, MBBS(Hons), MMed, FRANZCO; Penny A. McKelvie, MD, PhD; Kaustubh Mulay, DNB; Jan U. Prause, MD, DMSc; Elisabeth Ralfkiaer, MD, DMSc; Lene D. Sjö, MD, PhD; Matthew C. Sniegowski, MD; Geeta K. Vemuganti, MD; Steffen Heegaard, MD, DMSc
Includes: Supplemental Content

Importance  The clinical features of diffuse large B-cell lymphoma (DLBCL) subtype of ocular adnexal lymphoma have not previously been evaluated in a large cohort to our knowledge.

Objective  To investigate the clinical features of ocular adnexal DLBCL (OA-DLBCL).

Design, Setting, and Participants  This retrospective international ...

Original Investigation 
Cynthia Owsley, PhD; Gerald McGwin Jr, PhD; David J. Lee, PhD; Byron L. Lam, MD; David S. Friedman, MD, PhD; Emily W. Gower, PhD; Julia A. Haller, MD; Lisa A. Hark, PhD; Jinan Saaddine, MD; for the Innovative Network for Sight (INSIGHT) Research Group
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  The use of a nonmydriatic camera for retinal imaging combined with the remote evaluation of images at a telemedicine reading center has been advanced as a strategy for diabetic retinopathy (DR) screening, particularly among patients with diabetes mellitus from ethnic/racial minority populations with low utilization of ...

Invited Commentary 
Julia A. Haller, MD
If the state of affairs documented by Franco-Cardenas and colleagues in their article1 on women’s authorship in the “big 3” ophthalmic publications continues—and their survey suggests no reason to believe otherwise—this 1 opinion piece increases by 20% the count of female-penned editorials in all 3 of our highest-impact ophthalmology journals ...
Comment & Response 
Richard F. Spaide, MD
To the Editor I read with interest the article titled “Progressive Outer Retinal Necrosis (PORN): A Catchy Acronym But Is the Anatomy Correct? The Salient Observation of Lorenz E. Zimmerman, MD.”1 In 1996, my colleagues and I reported the first series of patients, to our knowledge, with the diagnosis of ...
Comment & Response 
Rajesh Ramanjulu, MD, DNB, FVR, FAICO(VR); Mahesh Shanmugam Palanivelu, FRCSEd, DO, FRCS(Edin), PhD
To the Editor We read the article by Ghassemi et al1 about the combination treatment with intravitreal melphalan hydrochloride and topotecan hydrochloride for resistant vitreous seeds with great interest. The 3 main practical concerns regarding the rationale for this therapy include the following: (1) the primary question, ie, does the ...
Comment & Response 
Curtis E. Margo, MD, MPH; Scott M. Friedman, MD
In Reply Spaide questions why we selected the case report of PORN by Greven et al1 as a key reference when the association with varicella-zoster virus infection was established by polymerase chain reaction and not by light or electron microscopic localization of viral inclusions or capsids. First, we believe the ...
Comment & Response 
Fariba Ghassemi, MD; Carol L. Shields, MD; Alireza Khodabande, MD
In Reply We appreciate the thoughtful comments of Ramanjulu and Palanivelu. We agree that intravenous or intra-arterial chemotherapy can often control vitreous seeds from retinoblastoma. Furthermore, we agree that single-agent intravitreal melphalan can control vitreous seeds in most cases.1- 4 However, a void remains in which single-agent intravitreal chemotherapy has ...
Ophthalmic Images 
Thanos D. Papakostas, MD; Yoshihiro Yonekawa, MD; Yewlin E. Chee, MD; Cynthia X. Qian, MD; Ivana K. Kim, MD
Graphic Jump LocationA, Traumatic cataract in a 16-year-old boy with anterior capsular folds (white arrowheads) and posterior capsular concavity (black arrowhead). Intraocular pressure was 55 mm Hg. Ultrasonographic biomicroscopy revealed hyperacoustic material (arrowhead) in the anterior chamber (B) and a large posterior capsular defect (arrowheads) (C).
Original Investigation 
Sachi Kojima, MD; Toshihiro Inoue, MD; Kei-Ichi Nakashima, MD; Ayako Fukushima, MD; Hidenobu Tanihara, MD
Includes: Supplemental Content

Importance  Posttrabeculectomy changes in bleb parameters measured using 3-dimensional (3-D) anterior-segment optical coherence tomography (OCT) remain uncharacterized and might be related to postsurgical intraocular-pressure (IOP) control.

Objective  To evaluate time-dependent posttrabeculectomy changes in filtering bleb parameters using 3-D anterior-segment OCT.

Design, Setting, and Participants  This ...

Original Investigation 
Fiona Blanco-Kelly, MD, PhD; Teresa Jaijo, PhD; Elena Aller, PhD; Almudena Avila-Fernandez, PhD; María Isabel López-Molina, MD; Ascensión Giménez, BSc; Blanca García-Sandoval, MD, PhD; José M. Millán, PhD; Carmen Ayuso, MD, PhD
Includes: Supplemental Content

Importance  A new statistical approach is needed to describe the clinical differences between type I and type II Usher syndrome and between the 2 most frequent mutations in the USH2A gene.

Objectives  To describe the primary phenotypic characteristics and differences between type I and type ...

Surgical Technique 
Tristan Bourcier, MD, PhD; Pierre-Henri Becmeur, MD; Didier Mutter, MD, PhD
Includes: Supplemental Content
Amniotic membrane transplant (AMT) is a surgical technique for ocular surface reconstruction that should be considered for acute chemical or thermal burns, painful bullous keratopathy, shield ulcers, severe bacterial keratitis, necrotizing herpetic keratitis, corneal thinning, refractory neurotrophic keratitis, and other persistent epithelial defects (PED).1 The literature describes several techniques to ...
Research Letter 
Marcela Marsiglia, MD, PhD; Winston Lee, BS; Vinit B. Mahajan, MD, PhD; Jana Zernant, MS; François C. Delori, PhD; Stephen H. Tsang, MD, PhD; Janet R. Sparrow, PhD
Homozygous and compound heterozygous mutations in ABCA4 are associated with multiple phenotypes, including bull’s-eye maculopathy (BEM).1 The BEM fundus patterning can also be conferred by other genes such as the retinitis pigmentosa guanosine triphosphatase regulator gene (RPGR), a gene that encodes a protein involved in trafficking to the outer segment.2 ...
Alex Sá, MD; Sigrid Arruda, MD; Marcos J. Cohen, MD; João M. Furtado, MD, PhD
There are multiple reports in the literature describing ocular trauma due to bee and wasp stings, and most of the complications are caused by either venom or the local inflammatory reaction,1 potentially leading to corneal edema, uveitis, cataract,1,2 and, less frequently, optic neuritis.3 Although there are controversies in the management ...

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