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Research Letters | April 18, 2013 
Interval Spectral-Domain Optical Coherence Tomography and Electrophysiology Findings in Neonatal Adrenoleukodystrophy
Robert J. Courtney, MD; Mark E. Pennesi, MD, PhD
A 20-month-old boy was referred for examination following a diagnosis of neonatal adrenoleukodystrophy (NALD). He initially presented with delayed developmental milestones, hypotonia, ...
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JAMA Ophthalmol. Published online April 18, 2013. doi:10.1001/jamaophthalmol.2013.2089
Clinical Sciences | April 18, 2013 
Macular Edema After Cataract Surgery in Eyes Without Preoperative Central-Involved Diabetic Macular Edema
Diabetic Retinopathy Clinical Research Network*
Includes: Supplemental Content
ImportanceImportance The incidence of development or worsening of macular edema (ME) is variable in eyes without diabetic ME (DME) undergoing cataract surgery.ObjectiveObjective ...
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JAMA Ophthalmol. Published online April 18, 2013. doi:10.1001/jamaophthalmol.2013.2313
Laboratory Sciences | April 18, 2013 
Transcription, Translation, and Function of Lubricin, a Boundary Lubricant, at the Ocular Surface
Tannin A. Schmidt, PhD; David A. Sullivan, PhD; Erich Knop, MD, PhD; Stephen M. Richards, ALM; Nadja Knop, MD, PhD; Shaohui Liu, MD, PhD; Afsun Sahin, MD; Raheleh Rahimi Darabad, MD; Sheila Morrison, BSc; Wendy R. Kam, MSc; Benjamin D. Sullivan, PhD
Includes: Supplemental Content
ImportanceImportance Lubricin may be an important barrier to the development of corneal and conjunctival epitheliopathies that may occur in dry eye disease ...
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JAMA Ophthalmol. Published online April 18, 2013. doi:10.1001/jamaophthalmol.2013.2385
Research Letters | April 18, 2013 
Fingolimod-Associated Macular Edema: Resolution by Sub-Tenon Injection of Triamcinolone With Continued Fingolimod Use
Ashley Minuk, BSc; Michel J. Belliveau, MD; David R. P. Almeida, MD, PhD, MBA; Stephen J. Dorrepaal, MD, FRCSC; Jeffrey S. Gale, MD, FRCSC
Fingolimod (Gilenya) is an oral immunosuppressant approved for the treatment of relapsing forms of multiple sclerosis. In clinical trials, macular edema (ME) ...
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JAMA Ophthalmol. Published online April 18, 2013. doi:10.1001/jamaophthalmol.2013.2465
Clinical Trials | April 11, 2013 
Three-Month Randomized Trial of Fixed-Combination Brinzolamide, 1%, and Brimonidine, 0.2%
Gregory Katz, MD; Harvey DuBiner, MD; John Samples, MD; Steven Vold, MD; Kenneth Sall, MD
Includes: Supplemental Content
ImportanceImportance This study evaluates the contribution of the individual components of an investigational non–β-antagonist fixed combination of brinzolamide, 1%, and brimonidine, 0.2%. ...
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JAMA Ophthalmol. Published online April 11, 2013. doi:10.1001/jamaophthalmol.2013.188
Research Letters | April 11, 2013 
Decreased Surface Temperature of Tarsal Conjunctiva in Patients With Meibomian Gland Dysfunction
Reiko Arita, MD, PhD; Rika Shirakawa, MD; Shuji Maeda, MD, PhD; Masahiko Yamaguchi, MD, PhD; Yuichi Ohashi, MD, PhD; Shiro Amano, MD, PhD
Meibomian glands secrete lipid into the tear film, thereby forming a thin oily layer on the tear film to prevent excessive evaporation ...
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JAMA Ophthalmol. Published online April 11, 2013. doi:10.1001/jamaophthalmol.2013.1895
Research Letters | April 11, 2013 
Histopathologic, Immunohistochemical, and Cytogenetic Analysis of Primary Clear Cell Melanoma of the Uvea
Robert M. Verdijk, MD, PhD; Anna E. Koopmans, MD; Emine Kilic, MD, PhD; Dion Paridaens, MD, PhD; Annelies de Klein, PhD
The histologic findings of malignant melanoma may be highly variable, and the tumor can mimic many other neoplasms.1 We describe a case ...
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JAMA Ophthalmol. Published online April 11, 2013. doi:10.1001/jamaophthalmol.2013.1939
Clinical Sciences | April 11, 2013 
Mycobacterial Ocular Inflammation:  Delay in Diagnosis and Other Factors Impacting Morbidity
Sarju S. Patel, MD, MPH, MSc; Nehali V. Saraiya, MD; Howard H. Tessler, MD; Debra A. Goldstein, MD
ImportanceImportance The reported outcomes of ocular mycobacterial infection are commonly unfavorable. This study is among the first to elucidate factors associated with ...
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JAMA Ophthalmol. Published online April 11, 2013. doi:10.1001/jamaophthalmol.2013.71
Clinical Sciences | April 11, 2013 
Effects of Graft Thickness and Asymmetry on Visual Gain and Aberrations After Descemet Stripping Automated Endothelial Keratoplasty
Mor M. Dickman, MD; Yanny Y. Y. Cheng, MD; Tos T. J. M. Berendschot, PhD; Frank J. H. M. van den Biggelaar, PhD; Rudy M. M. A. Nuijts, MD, PhD
ImportanceImportance Understanding the contribution of graft thickness and asymmetry to visual gain and posterior corneal (PC) higher-order aberrations (HOAs) may assist optimizing ...
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JAMA Ophthalmol. Published online April 11, 2013. doi:10.1001/jamaophthalmol.2013.73
Ophthalmic Molecular Genetics | April 9, 2013 
Temporal Macular Thinning Associated With X-Linked Alport Syndrome
Faisal Ahmed, MD; Kandon K. Kamae, MD; Denise J. Jones, BS; Margaret M. DeAngelis, PhD; Gregory S. Hageman, PhD; Martin C. Gregory, MD, PhD; Paul S. Bernstein, MD, PhD
ImportanceImportance Optical coherence tomography (OCT) findings of temporal macular thinning are important in the diagnosis and prognosis of X-linked Alport syndrome (XLAS).ObjectivesObjectives ...
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JAMA Ophthalmol. Published online April 09, 2013. doi:10.1001/jamaophthalmol.2013.1452
Research Letters | April 9, 2013 
Mutational Analysis of GNAQ and GNA11 to Aid Therapy Management of a Choroidal Melanoma Metastatic to the Contralateral Orbit
Michael R. R. Böhm, MD; Athanasios Tsianakas, MD; Ralph-Laurent Merté, MD; Meinhard Schiller, MD; Tilmann Spieker, MD; Albrecht Röpke, PhD; Andreas Bräuninger, PhD; Ulrike H. Grenzebach, MD
Metastasis to the contralateral orbital cavity in uveal melanoma (UM) is extremely rare.1 Only 8 cases of such metastases have been reported, ...
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JAMA Ophthalmol. Published online April 09, 2013. doi:10.1001/jamaophthalmol.2013.1921
Small Case Series | April 9, 2013 
Novel Mutation in BEST1 Associated With Retinoschisis
Ruwan A. Silva, MD; Audina M. Berrocal, MD; Byron L. Lam, MD; Thomas A. Albini, MD
Best vitelliform macular dystrophy (BVMD) is caused by mutations in BEST1 (also known as VMD2; OMIM 153700) on the long arm of ...
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JAMA Ophthalmol. Published online April 09, 2013. doi:10.1001/jamaophthalmol.2013.2047
Research Letters | April 9, 2013 
Mutation of GNAQ in a Cytologically Unusual Choroidal Melanoma in an 18-Month-Old Child
Steve Daniel Levasseur, MD; Katherine E. Paton, MD, FRCSC; Catherine D. Van Raamsdonk, BSc, MA, PhD; Manraj K. S. Heran, MD, FRCPC; Valerie Ann White, MD, MHSc, FRCPC
Fewer than 1% of uveal melanomas (UMs) occur in patients younger than 20 years.1 We report a histologically unusual UM in a ...
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JAMA Ophthalmol. Published online April 09, 2013. doi:10.1001/jamaophthalmol.2013.2483
Small Case Series | April 9, 2013 
Congenital Bilateral Aplasia of Medial Recti in a Family
Anirudh Singh, MS; Anudeepa Sharma, MBBS; Pradeep Sharma, MD, FAMS
A 50-year-old male patient from a nonconsanguineous marriage (case 1) was seen with outward deviation of both eyes since birth. He and ...
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JAMA Ophthalmol. Published online April 09, 2013. doi:10.1001/jamaophthalmol.2013.2889
Research Letters | April 9, 2013 
Coding Variants in ARMS2 and the Risk of Age-Related Macular Degeneration
Gaofeng Wang, PhD; William K. Scott, PhD; Anita Agarwal, MD; Jonathan L. Haines, PhD; Margaret A. Pericak-Vance, PhD
Includes: Supplemental Content
Genetic variation at the chromosome 10q26 locus is strongly associated with the risk of age-related macular degeneration (AMD). Recently, the common coding ...
JAMA Ophthalmol. Published online April 09, 2013. doi:10.1001/jamaophthalmol.2013.589
Research Letters | April 9, 2013 
De Novo Splice Mutation in the Versican Gene in a Family With Wagner Syndrome
Pierre-Raphaël Rothschild, MD; Isabelle Audo, MD, PhD; Brigitte Nedelec; Tiffany Ghiotti; Antoine P. Brézin, MD, PhD; Claire Monin, MD; Sophie Valleix, MD, PhD
Wagner syndrome (WS; OMIM 143200) is a rare inherited vitreoretinopathy caused by mutations in the canonical consensus sites of exon 7 or ...
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JAMA Ophthalmol. Published online April 09, 2013. doi:10.1001/jamaophthalmol.2013.681
Small Case Series | April 4, 2013 
Immunological Rejection Following Allogeneic Cultivated Limbal Epithelial Transplantation
Yoshiyuki Satake, MD, PhD; Murat Dogru, MD, PhD; Takefumi Yamaguchi, MD; Daisuke Tomida, MD, PhD; Masatoshi Hirayama, MD; Jun Shimazaki, MD, PhD
Allogeneic cultivated limbal epithelial transplantation (CLET), including living-related CLET, is recommended for bilateral cases with limbal stem cell deficiency or for unilateral ...
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JAMA Ophthalmol. Published online April 04, 2013. doi:10.1001/jamaophthalmol.2013.15
Research Letters | April 4, 2013 
Lichen Simplex Chronicus of the Conjunctiva
Heather D. Potter, MD; Vivian Lee, MD; Molly A. Hinshaw, MD; Sherif S. Khedr, MD; Daniel M. Albert, MD; Cat N. Burkat, MD
Lichen simplex chronicus (LSC) is a disorder commonly encountered by dermatologists, caused by constant rubbing of the skin that clinically induces thickening ...
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JAMA Ophthalmol. Published online April 04, 2013. doi:10.1001/jamaophthalmol.2013.1890
Research Letters | April 4, 2013 
Prenatal Presentation of Fronto-orbital Congenital Infantile Fibrosarcoma: A Clinicopathologic Report
Hughie H. Tsang, MBBS; Peter J. Dolman, MD, FRCSC; Douglas J. Courtemanche, MD, MS, FRCSC; Shahrad Rod Rassekh, MD, MHSc, FRCPC; Christof Senger, MD, FRCPC; Christopher J. Lyons, MBBS, FRCSC
Congenital infantile fibrosarcoma (CIFS) is a mesenchymal tumor that occurs in the first year of life and rarely involves the orbit. We ...
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JAMA Ophthalmol. Published online April 04, 2013. doi:10.1001/jamaophthalmol.2013.1934
Clinical Sciences | April 4, 2013 
Cultivated Limbal Epithelial Transplantation in Children With Ocular Surface Burns
Kunjal Sejpal, FRCS; Mohammed Hasnat Ali, MBA; Savitri Maddileti, MSc; Sayan Basu, MS; Muralidhar Ramappa, MS; Ramesh Kekunnaya, FRCS; Geeta K. Vemuganti, MD; Virender S. Sangwan, MS
ImportanceImportance Although several reports are available on the use of conventional and cultured limbal epithelium using various substrates in the treatment of ...
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JAMA Ophthalmol. Published online April 04, 2013. doi:10.1001/jamaophthalmol.2013.2308

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