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 Showing 1-20 of 56 Articles
Original Investigation  FREE
Robert E. Wiggins Jr, MD, MHA; Rebecca Etz, PhD

Importance  There is disagreement as to whether Maintenance of Certification is creating value for physicians and their patients. To our knowledge, this report provides the first measures of the effectiveness of Part 4 of this activity in assisting ophthalmologists with quality improvement in their practices.

Objective  ...

Invited Commentary: The Value of Maintenance of Certification; Hilary A. Beaver, MD
Original Investigation 
Sayantan Biswas, MPhil; Chen Lin, BM; Christopher K. S. Leung, MD

Importance  Analysis of retinal nerve fiber layer (RNFL) abnormalities with optical coherence tomography in eyes with high myopia has been complicated by high rates of false-positive errors. An understanding of whether the application of a myopic normative database can improve the specificity for detection of RNFL abnormalities ...

Invited Commentary: Optical Coherence Tomography in High Myopia; Joel S. Schuman, MD
Original Investigation 
Susan Vitale, PhD, MHS; Traci E. Clemons, PhD; Elvira Agrón, MA; Frederick L. Ferris III, MD; Amitha Domalpally, MD; Ronald P. Danis, MD; Emily Y. Chew, MD; for the Age-Related Eye Disease Study 2 (AREDS2) Research Group
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  To test potential treatments for age-related macular degeneration (AMD), clinical trials need standardized outcome measures that are valid for predicting AMD progression in different study populations.

Objective  To evaluate the validity of the Age-Related Eye Disease Study (AREDS) detailed and simple AMD severity scales by ...

Invited Commentary: Use of the AREDS Severity Scale for Age-Related Macular Degeneration; Chui Ming Gemmy Cheung, FRCOphth; Tien Yin Wong, MBBS, PhD, FRCS(Ed)
Invited Commentary 
Hilary A. Beaver, MD

All physicians want to give their patients the best quality care and to believe that they themselves have kept abreast of new information and technology. All patients want to believe that their physicians are wise, learned, and up to date on the condition for which they are consulting. ...

Invited Commentary 
Joel S. Schuman, MD

Optical coherence tomography (OCT) is a precise technology that can be used for interrogating tissue structure and function noninvasively, painlessly, and quickly using near-infrared light. At its inception, OCT was typically a tool for assessing tissue thickness. Time-domain OCT is fast enough to scan a circle centered on ...

Invited Commentary 
Chui Ming Gemmy Cheung, FRCOphth; Tien Yin Wong, MBBS, PhD, FRCS(Ed)

Numerous population-based epidemiologic studies13 have reported on the prevalence, incidence, and risk factors of age-related macular degeneration (AMD) in the United States and globally. One such study1 suggests that 6% to 8% of adults 40 years and older have signs of early-stage AMD. However, ...

JAMA Ophthalmology Clinical Challenge 
Rajesh C. Rao, MD; J. William Harbour, MD

A woman in her 50s with an unremarkable medical history noticed a gradually enlarging, white-brown, circular lesion on her right iris over the past several years but denied visual changes. Slitlamp examination of the anterior segment showed a 2 mm × 2 mm circular iris lesion at the inferotemporal border ...

Original Investigation 
Imam M. Xierali, PhD; Marc A. Nivet, EdD; M. Roy Wilson, MD
Includes: Supplemental Content

Importance  Increasing the level of diversity among ophthalmologists may help reduce disparities in eye care.

Objective  To assess the current and future status of diversity among ophthalmologists in the workforce by sex, race, and ethnicity in the context of the available number of medical students in ...

Original Investigation 
Michael S. Deiner, PhD; Thomas M. Lietman, MD; Stephen D. McLeod, MD; James Chodosh, MD, MPH; Travis C. Porco, PhD, MPH
Includes: Supplemental Content

Importance  Internet-based search engine and social media data may provide a novel complementary source for better understanding the epidemiologic factors of infectious eye diseases, which could better inform eye health care and disease prevention.

Objective  To assess whether data from internet-based social media and search engines ...

Brief Report 
Soundaram MeenakshiSundaram, MD; Aalia Rasool Sufi, MD; N. Venkatesh Prajna, MD; Jeremy D. Keenan, MD, MPH

Importance  In vivo confocal microscopy could be useful in cases of fungal or acanthamoeba keratitis to determine the depth of infectious elements, but its accuracy in determining corneal thickness relative to more traditional techniques has not been well characterized.

Observations  In this cross-sectional observational case series, ...

Brief Report 
Livia Tomasso, MDs; Lucia Benatti, MD; Adriano Carnevali, MD; Andrea Mazzaferro, MDs; Giovanni Baldin, MDs; Lea Querques, MD; Francesco Bandello, MD, FEBO; Giuseppe Querques, MD, PhD

Importance  The aim of this study is to determine whether the cross-shaped fixation target in a spectral-domain optical coherence tomography instrument (Spectralis; Heidelberg Engineering) could produce a cross-shaped increase fundus autofluorescence artifact on subsequent imaging.

Observations  Thirty eyes of 15 healthy volunteers (8 women and 7 ...

Our new era of clinical practice is largely the consequence of profound advances in imaging, devices, and therapeutics. But 2 other developments, outside our traditional domain, are beginning to affect our ability to predict, prepare for, and treat disease: “big data” and social media. The influence that big ...

JAMA Ophthalmology Clinical Challenge 
Mohsin H. Ali, MD; Felix Y. Chau, MD; Javaneh Abbasian, MD

A 2-year-old African American boy with leukocoria in his left eye noted during a routine well-child visit was unable to read the distance chart, had an APD and a white-yellow mass in the macula OS. What would you do next?

Original Investigation 
Sarah Hull, MA, FRCOphth; Gavin Arno, PhD; Anthony G. Robson, MSc, PhD; Suzanne Broadgate, PhD; Vincent Plagnol, PhD; Martin McKibbin, FRCOphth; Stephanie Halford, PhD; Michel Michaelides, MD(Res), FRCOphth; Graham E. Holder, MSc, PhD; Anthony T. Moore, MA, FRCOphth; Kamron N. Khan, PhD, FRCOphth; Andrew R. Webster, MD(Res), FRCOphth
Includes: Supplemental Content

Importance  Congenital hypotrichosis with juvenile macular dystrophy (HJMD) is a rare disorder presenting in childhood and adolescence with central visual disturbance and sparse scalp hair. Reported retinal imaging is lacking, and whether the condition is progressive remains unclear.

Objective  To investigate a series of patients with ...

Original Investigation 
Matthew A. Pimentel, BS; Erica N. Browne, MS; Priya M. Janardhana, MD; Durga S. Borkar, MD; Vivien M. Tham, MD; Aileen Uchida, MPH; Aleli C. Vinoya, BS; Nisha R. Acharya, MD, MS
Includes: Supplemental Content

Importance  With the increased use of data from electronic medical records for research, it is important to validate International Classification of Diseases, Ninth Revision (ICD-9) codes for their respective diagnoses.

Objective  To assess the accuracy of using ICD-9 codes to identify ocular inflammatory ...

Original Investigation 
Gwyneth Rees, PhD; Jing Xie, PhD; Eva K. Fenwick, PhD; Bonnie A. Sturrock, DPsych; Robert Finger, PhD; Sophie L. Rogers, MEpi; Lyndell Lim, MBBS, FRANZCO; Ecosse L. Lamoureux, PhD
Includes: Supplemental Content

Importance  This study is needed to clarify inconsistent findings regarding the association between diabetes-related eye complications and psychological well-being.

Objective  To examine the association between severity of diabetic retinopathy (DR) and diabetic macular edema (DME) with symptoms of depression and anxiety in adults with diabetes.

Design, ...

Invited Commentary: Depressive Symptoms in Ophthalmology Patients; Peter V. Rabins, MD, MPH
Brief Report 
Sarah Hull, MA, FRCOphth; Aeesha N. J. Malik, MRCP, FRCOphth; Gavin Arno, PhD; Donna S. Mackay, PhD; Vincent Plagnol, MSc, PhD; Michel Michaelides, MD(Res), FRCOphth; Sahar Mansour, BMBS, FRCP; Assunta Albanese, MD(Res), FRCPCH; Katrina Tatton Brown, BM BCh, MD(Res); Graham E. Holder, MSc, PhD; Andrew R. Webster, MD(Res), FRCOphth; Paul T. Heath, FRACP, FRCPCH; Anthony T. Moore, MA, FRCOphth
Includes: Supplemental Content

Importance  A multiorgan syndromic disorder characterized by sideroblastic anemia, immunodeficiency, periodic fever, and developmental delay with an uncharacterized retinal dystrophy is caused by TRNT1. This report of a family with a homozygous mutation in TRNT1 expands the ocular phenotype to include cataract and inner retinal dysfunction ...

Brief Report 
Jimmy T. Le, MA; Shilpa Viswanathan, PhD; Michelle E. Tarver, MD, PhD; Malvina Eydelman, MD; Tianjing Li, MD, MHS, PhD

Importance  Minimally invasive glaucoma surgical (MIGS) devices are one option for lowering intraocular pressure in patients with glaucoma.

Objective  To examine how often existing clinical studies of MIGS devices registered on ClinicalTrials.gov measure patient-centric outcomes that patients value directly.

Design, Setting, and Participants  We searched ...

Invited Commentary 
Peter V. Rabins, MD, MPH

Busy clinicians must balance their focus on the presenting disease of a patient with a duty to detect other comorbidities that the patient might be experiencing. Because depression affects 25% to 40% of individuals with significant eye pathology,1 it is reasonable to ask whether ophthalmologists should take ...

JAMA Ophthalmology Clinical Challenge 
Aubrey L. Gilbert, MD, PhD; Aristomenis Thanos, MD; Roberto Pineda, MD

An otherwise healthy woman in her 50s presented with blurry vision in both eyes after a routine eye examination with dilation 5 days earlier. The pupils were middilated and poorly reactive, and the lenses were displaced into the anterior chambers without any lenticular zonules visible. What would you ...

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