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 Showing 1-20 of 67 Articles
Original Investigation 
Julia D. Rossetto, MD; Sirinya Suwannaraj, MD; Kara M. Cavuoto, MD; Oriel Spierer, MD; Darlene Miller, DHSc, MPH; Craig A. McKeown, MD; Hilda Capo, MD
Includes: Supplemental Content

Importance  Although the association between suture colonization and postoperative infections remains hypothetical, measures to reduce perioperative suture colonization may minimize postoperative infections. The suture colonization rate in adjustable suture strabismus surgery is not well defined, and the effect of povidone-iodine use on suture colonization is unknown.


Invited Commentary: Postsurgical Infection Risk in Adjustable Suture Strabismus Surgery; David G. Hunter, MD, PhD
Original Investigation  FREE
Chiu-Fang Chou, DrPH; Gloria L. Beckles, MD, MSc; Yiling J. Cheng, MD, PhD; Jinan B. Saaddine, MD, MPH

Importance  Individual-level characteristics are associated with eye care use. The influence of contextual factors on vision and eye health, as well as health behavior, is unknown.

Objective  To examine the association between county-level characteristics and eye care use after accounting for individual-level characteristics using a conceptual ...

Invited Commentary: Role of Contextual Factors in Racial/Ethnic Disparities in Eye Care Use; Rohit Varma, MD, MPH; Xuejuan Jiang, PhD
Invited Commentary 
David G. Hunter, MD, PhD

Adjustable sutures are used in strabismus surgery to protect against undesirable short-term outcomes by allowing the surgeon to fine-tune the postoperative alignment before the extraocular muscle has firmly reattached to the globe. Reasonable evidence is now available that adjustable sutures can enhance surgical success rates by approximately 10%....

Invited Commentary 
Rohit Varma, MD, MPH; Xuejuan Jiang, PhD

Visual impairment and blindness are important causes of morbidity and mortality in older adults in the United States. Fortunately, most cases can be prevented by early detection and interventions. The American Academy of Ophthalmology 2015 guidelines1 recommend that adults at higher risk for certain ocular diseases (eg, ...

JAMA Ophthalmology Clinical Challenge 
Malini Veerappan, BA; Michael Seider, MD; Sharon Fekrat, MD

A man in his 60s presented with reduced visual acuity in his right eye and had vitritis, mild optic disc edema, scattered elevated white chorioretinal lesions, and a prominent macular lesion on examination following several urologic procedures. What would you do next?

Comment & Response 
Irena Tsui, MD

To the Editor On behalf of my coauthors, I report that it has come to our attention that there were unintentional statistical errors in our Original Investigation, “Decadelong Profile of Women in Ophthalmic Publications,” published in JAMA Ophthalmology online on November 13, 2014, and in the March 2015 ...

In the Original Investigation, “Decadelong Profile of Women in Ophthalmic Publications,” published in JAMA Ophthalmology online on November 13, 2014, and in the March 2015 print issue,1 there were statistical errors reported in the original article (some of the percentage differences, 95% CIs, and associated P values). ...

Original Investigation 
Ke Yang, MD; Ling Jin, MS; Li Li, MD; Siming Zeng, MD; Ruqian Wei, MD; Guirong Li, MD; Pingyi Man, MD; Nathan Congdon, MD, MPH
Includes: Supplemental Content

Importance  Follow-up after trabeculectomy surgery is important to surgical success, but little is known about the effect of interventions on improving follow-up in low-resource areas.

Objective  To examine whether text message reminders and free eye medications improve follow-up after trabeculectomy in rural southern China.

Design, Setting, ...

Original Investigation 
Aleix Sala-Vila, DPharm, PhD; Andrés Díaz-López, RD, PhD; Cinta Valls-Pedret, MSc; Montserrat Cofán, DPharm, PhD; Alfredo García-Layana, MD, PhD; Rosa-María Lamuela-Raventós, DPharm, PhD; Olga Castañer, MD, PhD; Vicente Zanon-Moreno, PhD; Miguel A. Martinez-Gonzalez, MD, PhD; Estefanía Toledo, MD, PhD; Josep Basora, MD, PhD; Jordi Salas-Salvadó, MD, PhD; Dolores Corella, DPharm, PhD; Enrique Gómez-Gracia, MD, PhD; Miquel Fiol, MD, PhD; Ramón Estruch, MD, PhD; José Lapetra, MD, PhD; Montserrat Fitó, MD, PhD; Fernando Arós, MD, PhD; Luis Serra-Majem, MD, PhD; Xavier Pintó, MD, PhD; Emilio Ros, MD, PhD; for the Prevención con Dieta Mediterránea (PREDIMED) Investigators
Includes: Supplemental Content

Importance  Diabetic retinopathy (DR) is a devastating complication of individuals with type 2 diabetes mellitus. The retina is rich in long-chain ω-3 polyunsaturated fatty acids (LCω3PUFAs), which are substrate for oxylipins with anti-inflammatory and antiangiogenic properties. Experimental models support dietary LCω3PUFA protection against DR, but clinical data ...

Invited Commentary: Eat Your Fish or Go for Nuts; Michael Larsen, MD, DMSc
Brief Report 
Philipp Roberts, MD; Gerald A. Fishman, MD; Komal Joshi, MD; Lee M. Jampol, MD

Importance  In recent years, the treatment of patients with advanced cutaneous melanoma has undergone substantial changes. Patients can now be offered treatment with immune checkpoint inhibitors, which are capable of increasing patient survival. However, these new treatments are associated with immune-related adverse effects that can involve different ...

Invited Commentary 
Michael Larsen, MD, DMSc

In this issue of JAMA Ophthalmology, Sala-Vila and coauthors1 present a post hoc analysis of data from the 6-year Prevención con Dieta Mediterránea (PREDIMED) Study, a large 3-arm cardiovascular end point intervention study comparing a low-fat diet, a Mediterranean diet supplemented by olive oil, and a ...

JAMA Ophthalmology Clinical Challenge 
Kinda Najem, MD; Edward A. Margolin, MD

A man aged 51 years presented with signs of Horner syndrome accompanying left-sided hemibody paresthesia, dysphasia, and ataxia. What would you do next?

Yamini Krishna, MBChB, PhD, FRCOphth; Iguaracyra Araujo, MD, PhD; Sunil Warrier, MBBS, MMed, FRANZCO; Heinrich Heimann, MD, FRCOphth; Sarah E. Coupland, MBBS, PhD, FRCPath

This case report describes a patient with systemic histiocytic sarcoma and choroidal infiltration of sarcoma cells.

Original Investigation 
Adriana Amaro, PhD; Federica Parodi, PhD; Konrad Diedrich, MSc; Giovanna Angelini, PhD; Cornelia Götz, MSc; Silvia Viaggi, PhD; Irena Maric, PhD; Domenico Coviello, MD, PhD; Maria Pia Pistillo, PhD; Anna Morabito; Mario Mandalà, MD; Paola Ghiorzo, PhD; Paola Visconti, PhD; Marina Gualco, MD; Luca Anselmi, MD; Roberto Puzone, PhD; Francesco Lanza, MD; Carlo Mosci, MD; Federica Raggi, PhD; Maria Carla Bosco, PhD; Luigi Varesio, PhD; Michael Zeschnigk, MD; Laura Spano, MD; Paola Queirolo, MD; Ulrich Pfeffer, PhD
Includes: Supplemental Content

Importance  Chromosome 6p amplification is associated with more benign behavior for uveal melanomas (UMs) with an otherwise high risk of metastasis conferred by chromosome 3 monosomy. Chromosome 6p contains several members of the B7 family of immune regulator genes, including butyrophilin-like 2 (BTNL2; OMIM, 606000...

Invited Commentary: Genetic Variants of the BTNL2 Gene in Uveal Melanoma; Sarah E. Coupland, MBBS, PhD, FRCPath; Yamini Krishna, MBChB, PhD, FRCOphth
Brief Report 
Michael A. Mahr, MD; Keith H. Baratz, MD; David O. Hodge, MS; Jay C. Erie, MD

Importance  Fuchs endothelial corneal dystrophy (FECD) is the most common indication for corneal transplant in the United States. The association between race/ethnicity and incidence of advanced FECD, defined by a need for endothelial or penetrating keratoplasty, has not been investigated.

Observations  The 2014 US Medicare Limited ...

Brief Report 
Abdhish R. Bhavsar, MD; Adam R. Glassman, MS; Cynthia R. Stockdale, MSPH; Lee M. Jampol, MD; for the Diabetic Retinopathy Clinical Research Network
Includes: Supplemental Content

Importance  This report provides updated endophthalmitis rates for eyes receiving intravitreous injections with and without povidone-iodine and rates with and without topical antibiotics from Diabetic Retinopathy Clinical Research Network clinical trials.

Observations  Among 8 Diabetic Retinopathy Clinical Research Network clinical trials conducted from 2006 to 2015, ...

Invited Commentary 
Sarah E. Coupland, MBBS, PhD, FRCPath; Yamini Krishna, MBChB, PhD, FRCOphth

Significant progress has been made in understanding the molecular pathology of uveal melanoma (UM). It is well known that genetic alterations, such as monosomy 3, polysomy 8q, and BAP1 gene-inactivating mutations, are associated with a poor prognosis in UM, whereas a gain in chromosome 6p is associated with ...

JAMA Ophthalmology Clinical Challenge 
Brenton D. Finklea, MD; Michael N. Cohen, MD; Robert C. Sergott, MD

A woman in her 30s with transverse sinus thrombosis and worsening symptoms has severe papilledema with optic nerve edema. What would you do next?

Comment & Response 
Carol L. Shields, MD; Jerry A. Shields, MD

To the Editor We acknowledge the time and effort of Yousef et al1 in their review of intra-arterial chemotherapy (IAC) for retinoblastoma. We agree with many of their thoughts including the abstract’s conclusion, “Intra-arterial chemotherapy is a promising new treatment associated with high rates of globe salvage,”...

Comment & Response 
David H. Abramson, MD; Brian P. Marr, MD; Jasmine H. Francis, MD

To the Editor We read with interest the article by Yousef et al.1 In their search for articles about intra-arterial chemotherapy (IAC) for retinoblastoma, they identified 208 but may have missed others as the search terms ophthalmic artery chemosurgery (OAC), intraarterial, and intra arterial were not ...

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