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 Showing 1-20 of 63 Articles
Original Investigation  FREE
Graham E. Quinn, MD, MSCE; Anna Ells, MD; Antonio Capone Jr, MD; G. Baker Hubbard, MD; Ebenezer Daniel, MD, PhD; P. Lloyd Hildebrand, MD; Gui-shuang Ying, PhD; for the e-ROP (Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity) Cooperative Group

Importance  As effective treatments for potentially blinding retinopathy of prematurity (ROP) have been introduced, the importance of consistency in findings has increased, especially with the shift toward retinal imaging in infants at risk of ROP.

Objective  To characterize discrepancies in findings of ROP between digital retinal ...

Invited Commentary: Telemedicine for Retinopathy of Prematurity; Ingrid E. Zimmer-Galler, MD
Original Investigation 
Johanna M. Seddon, MD, ScM; D. Scott McLeod; Imran A. Bhutto, MD, PhD; Mercedes B. Villalonga, BA; Rachel E. Silver, MPH; Adam S. Wenick, MD, PhD; Malia M. Edwards, PhD; Gerard A. Lutty, MS, PhD
Includes: Supplemental Content

Importance  Age-related macular degeneration (AMD) is a multifactorial disease with genetic and environmental factors contributing to risk. Histopathologic changes underlying AMD are not fully understood, particularly the relationship between choriocapillaris (CC) dysfunction and phenotypic variability of this disease.

Objective  To examine histopathologic changes in the CC ...

Invited Commentary: Insight Into Neovascular Age-Related Macular Degeneration; Thaddeus P. Dryja, MD
Invited Commentary 
Thaddeus P. Dryja, MD

One is occasionally struck by a basic scientific question that has been curiously neglected for study. Sometimes the question is neglected because everyone takes a presumed answer for granted. Sometimes nobody feels the question is of sufficient importance to warrant investigation. As an example of such a question, ...

Invited Commentary 
Ingrid E. Zimmer-Galler, MD

Telemedicine technology is increasingly being incorporated into mainstream ophthalmology. Remote fundus imaging is most frequently used in the context of screening for treatable retinal diseases, and robust ocular telehealth programs with mature reading centers now exist to identify vision-threatening diseases in patients with diabetes. Similar advances are being ...

JAMA Ophthalmology Clinical Challenge 
Ivy Zhu, BA; Andrew W. Francis, MD; M. Soledad Cortina, MD

A woman in her 30s with bilateral papilledema had an elevated optic disc with blurred margins and loss of the central physiologic cup on fundus examination. What would you do next?


In the Original Investigation titled “Evaluation of a Myopic Normative Database for Analysis of Retinal Nerve Fiber Layer Thickness,”1 published in the September issue of JAMA Ophthalmology, the wrong author’s name was listed with the financial disclosure included in the Conflict of Interest Disclosures section. The ...

Original Investigation 
Zachary Keenum, BS; Gerald McGwin Jr, PhD; C. Douglas Witherspoon, MD; Julia A. Haller, MD; Mark E. Clark; Cynthia Owsley, PhD

Importance  The public health success of diabetic retinopathy (DR) screening programs depends on patients’ adherence to the timetable of follow-up eye care recommended by the screening program. African Americans are among those at highest risk for DR and have one of the lowest rates of eye care ...

Invited Commentary: Improving Ocular Telehealth Outcomes; Christopher J. Brady, MD
Original Investigation 
Barbara M. Wirostko, MD; Karen Curtin, PhD; Robert Ritch, MD; Samuel Thomas, MD; Kristina Allen-Brady, PhD; Ken R. Smith, PhD; Gregory S. Hageman, PhD; R. Rand Allingham, MD

Importance  Exfoliation syndrome, an inherited systemic disorder of elastin and extracellular matrix (ECM), is associated with the LOXL1 gene locus. Pelvic organ prolapse is a common connective tissue disorder that affects women. The presence of an association between exfoliation syndrome (exfoliation of the lens capsule) and pelvic ...

Brief Report 
Daria Van Tyne, PhD; Joseph B. Ciolino, MD; Jay Wang, MD; Marlene L. Durand, MD; Michael S. Gilmore, PhD
Includes: Supplemental Content

Importance  Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are highly antibiotic resistant, and primary ocular infection by ESBL E coli has rarely been reported. A novel mutation conferring phagocytosis resistance would position a strain well to infect the cornea.

Observations  A woman with recurrent keratitis presented with a ...

Invited Commentary 
Christopher J. Brady, MD

It has now been well established that a nonmydriatic camera located well outside the ophthalmologist or optometrist office can be used to capture images of the retinal fundus for remote interpretation. In the setting of diabetic retinopathy, this “store-and-forward” paradigm has been validated against clinical examination and as ...

JAMA Ophthalmology Clinical Challenge 
Judy Chen, MD; Yannek Leiderman, MD, PhD; Aisha Traish, MD

An otherwise healthy white man in his 40s had decreased vision with a white cataract and tearing, photophobia, and burning in his left eye. He had been treated for a corneal abrasion and treated with topical antibiotics 1 year prior. What would you do next?

Research Letter  FREE
Jiufeng Sun, PhD; De Wu, PhD; Haojie Zhong; Dawei Guan; Huan Zhang; Qiqi Tan; Changwen Ke, PhD

This study examines whether Zika virus can be detected in conjunctival fluid.

Original Investigation 
Jennifer E. Thorne, MD, PhD; Eric Suhler, MD, MPH; Martha Skup, PhD; Samir Tari, MD, MBA; Dendy Macaulay, PhD; Jingdong Chao, PhD; Arijit Ganguli, PhD, MBA
Includes: Supplemental Content

Importance  Noninfectious uveitis (NIU) is a collection of intraocular inflammatory disorders that may be associated with significant visual impairment. To our knowledge, few studies have investigated NIU prevalence overall or stratified by inflammation location, severity, presence of systemic conditions, age, or sex.

Objective  To estimate NIU ...

Invited Commentary: Uveitides in the United States; Douglas A. Jabs, MD, MBA
Original Investigation 
Caroline L. S. Kilduff, MBBS; Edward J. Casswell, MBBS; Tahrina Salam, FRCOphth; Dov Hersh, MBBS, FRANZCO; Santiago Ortiz-Perez, PhD, FRCOphth; Daniel Ezra, MD, FRCOphth

Importance  Patients with benign essential blepharospasm or hemifacial spasm are known to use botulinum toxin injections and alleviating maneuvers to help control their symptoms. The clinical correlates between the use of botulinum toxin injections and the use of alleviating maneuvers are not well established.

Objective  To ...

Invited Commentary: Alleviating Maneuvers for Dystonias; Andrew G. Lee, MD; Neil R. Miller, MD
Invited Commentary 
Andrew G. Lee, MD; Neil R. Miller, MD

In this issue of JAMA Ophthalmology, Kilduff et al1 report the largest published observational series to date of the use of alleviating maneuvers by patients with benign essential blepharospasm (BEB) or hemifacial spasm (HFS). The authors found that 39 of 74 patients with BEB (52.7%) and ...

Invited Commentary 
Douglas A. Jabs, MD, MBA

The uveitides are a collection of more than 30 diseases characterized by intraocular inflammation.1,2 Collectively, they are the fifth or sixth leading cause of blindness in the United States, and the cost of treating the uveitides has been estimated to rival that of treating diabetic ...

JAMA Ophthalmology Clinical Challenge 
Mohsin H. Ali, MD; Scott Jones, MD; Heather E. Moss, MD, PhD

A woman had worsening bulging, redness, and mild pain in her right eye; imaging, angiography, and venography of the brain and orbits revealed extraocular muscle enlargement and enhancement. What would you do next?

Comment & Response 
Timothy L. Jackson, PhD, FRCOphth; Paul H. J. Donachie, MSc; Robert L. Johnston, FRCOphth

To the Editor We read with interest the thoughtful Invited Commentary by Browning1 on our database study of diabetic vitrectomy.2 Browning highlights the difficulties of database studies and how they might be addressed. For example, can we manually validate the electronic operation note against the patient’s ...

Comment & Response 
David J. Browning, MD, PhD

In Reply Jackson and colleagues note that validating electronic medical records against the patient’s medical file is not commonly done. If progress is to be made, old methods might need to be revised. There is no reason why validation of outcomes cannot be performed by checking the electronic ...

Original Investigation 
Ahmed M. Bata, MD; Katarzyna J. Witkowska, MD, PhD; Piotr A. Wozniak, MD; Klemens Fondi, MD; Gerald Schmidinger, MD; Niklas Pircher, MD; Stephan Szegedi, MD; Valentin Aranha dos Santos, MSc; Anca Pantalon, MD; René M. Werkmeister, PhD; Gerhard Garhofer, MD; Leopold Schmetterer, PhD; Doreen Schmidl, MD, PhD
Includes: Supplemental Content

Importance  Corneal abrasions are frequent after standard (epithelium-off [epi-off]) corneal collagen cross-linking (CXL) in patients with progressive keratoconus. A new matrix therapy agent (ReGeneraTing Agent [RGTA]) has been developed to promote corneal wound healing.

Objective  To assess the effect of the new type of matrix therapy ...

Invited Commentary: Corneal Epithelial Wound Healing; Bennie H. Jeng, MD

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