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 Showing 1-20 of 68 Articles
JAMA Ophthalmology Clinical Challenge 
Kai B. Kang, MD; Jennifer I. Lim, MD

A woman in her early 40s with a history of recurrent meningioma of the right sphenoid wing after tumor resections, followed by adjuvant radiation, presented with fluctuating vision in the right eye for several months. Her best-corrected visual acuity was 20/20 OD and 20/20 OS. What would you ...

Research Letter  FREE
Scott M. McClintic, MD; Yali Jia, PhD; David Huang, MD, PhD; Steven T. Bailey, MD

This case report describes the use of optical coherence tomographic angiography to detect choroidal neovascularization.

Brief Report 
Michael C. Struck, MD
Includes: Supplemental Content

Importance  Pediatric primary posterior intraocular lens (IOL) implantation in children older than 24 months has become the standard of care. Results of the Infantile Aphakia Treatment Study have concluded that primary IOL implantation before age 7 months has no advantages over aphakia. The current evidence does not ...

Brief Report 
Judy H. Jun, BS; John C. Hwang, MD, MBA

Importance  Rivaroxaban is an anticoagulant prescribed for the management of atrial fibrillation. We describe a correlation between rivaroxaban and spontaneous vitreous hemorrhage.

Observations  Three patients developed spontaneous vitreous hemorrhage after initiating rivaroxaban anticoagulation. All 3 patients were taking an additional anticoagulant at the time of hemorrhage....

Research Letter 
Caroline R. Baumal, MD; Talisa E. de Carlo, BA; Nadia K. Waheed, MD, MPH; David A. Salz, MD; Andre J. Witkin, MD; Jay S. Duker, MD

This case report describes choroidal neovascularization in multifocal choroiditis diagnosed using optical coherence tomographic angiography.

Research Letter  FREE
N. Venkatesh Prajna, MD; Lalitha Prajna, MD; Kieran S. O’Brien, MPH; Catherine Q. Sun, MD; Nisha Acharya, MD; Thomas M. Lietman, MD; Jennifer Rose-Nussbaumer, MD; for the Mycotic Ulcer Treatment Trial Group

This study evaluates whether pretreatment with antifungal medications has an effect on fungal resistance in fungal ulcers.

Ebba J. Nissen, MD; Helen Kalirai, PhD; Bertil Damato, MD, PhD; Heinrich Heimann, MD, FRCOphth; Sarah E. Coupland, MBBS, PhD, FRCPath

This case report describes separate uveal melanomas in the same eye.

This Viewpoint discusses the early findings of the Diabetic Retinopathy Clinical Research Network, which is comparing the effectiveness of aflibercept, bevacizumab, and ranibizumab in patients with diabetic macular edema.

Original Investigation  FREE
Ahmad A. Aref, MD; Ingrid U. Scott, MD, MPH; Neal L. Oden, PhD; Michael S. Ip, MD; Barbara A. Blodi, MD; Paul C. VanVeldhuisen, PhD; for the SCORE Study Investigator Group
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  The Standard of Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) Study showed that intravitreal triamcinolone acetonide (IVTA) is effective at reducing macular edema and improving visual acuity in participants with retinal vein occlusion. Secondary analysis of the incidence, risk factors, and timing of intraocular pressure ...

Original Investigation 
Andrew Chen, BS; Fei Yu, PhD; Simon K. Law, MD; JoAnn A. Giaconi, MD; Anne L. Coleman, MD, PhD; Joseph Caprioli, MD
Includes: Supplemental Content

Importance  Relatively little data exist about the long-term outcomes of an initial glaucoma drainage device (GDD) and subsequent GDDs implanted in pediatric patients with glaucoma.

Objective  To determine the long-term outcomes of the first and second GDDs and risk factors in pediatric glaucoma.

Design, Setting, and ...

Brief Report 
Michael A. Klufas, MD; Sujit Itty, MD; Colin A. McCannel, MD; Ben J. Glasgow, MD; Christian Moreno, BS; Tara A. McCannel, MD, PhD

Importance  We report our experience with uveal melanoma–specific gene expression profile (GEP) testing on a series of choroidal metastatic tumors confirmed by cytopathology so that clinicians may be aware that receiving a class 1 or class 2 test result in nonmelanoma is possible.

Observations  Retrospective review ...

Brief Report 
Lucy Q. Shen, MD; Carolyn E. Kloek, MD; Angela V. Turalba, MD
Includes: Supplemental Content

Importance  Subspecialty surgical training is an important part of resident education. We changed the glaucoma rotation in which postgraduate year 4 residents worked with multiple attending physicians with varying teaching styles to a structured surgical curriculum led by 2 dedicated preceptors, and we evaluated the effect on ...

Abdhish R. Bhavsar, MD; Danielle R. Sandler, BA; Amanda C. Maltry, MD

This case report describes malignant melanoma with perivascular retinal invasion.

Original Investigation  FREE
Rohit Varma, MD, MPH; Julia A. Haller, MD; Peter K. Kaiser, MD
Includes: Supplemental Content

Importance  The impact of vitreomacular adhesion (VMA) resolution on patient-reported visual function in symptomatic VMA/vitreomacular traction (VMT) has not yet been documented, to our knowledge.

Objective  To determine the impact of intravitreal ocriplasmin on patient-reported visual function using the 25-item National Eye Institute Visual Function Questionnaire ...

Original Investigation  FREE
David M. Weiss, BA; Robin J. Casten, PhD; Benjamin E. Leiby, PhD; Lisa A. Hark, PhD; Ann P. Murchison, MD, MPH; Deiana Johnson, MPH; Shayla Stratford, MHSA; Jeffrey Henderer, MD; Barry W. Rovner, MD; Julia A. Haller, MD
Includes: Supplemental Content

Importance  African American individuals are at high risk of diabetes mellitus and diabetic retinopathy but have suboptimal rates of dilated fundus examinations (DFEs). Early intervention is crucial for the prevention of diabetic retinopathy in this high-risk population.

Objective  To test the efficacy of behavioral activation for ...

Original Investigation 
Gaia Barisione, MSc; Marina Fabbi, MD, PhD; Alice Gino, MSc; Paola Queirolo, MD; Laura Orgiano, MD; Laura Spano, MD; Virginia Picasso, MD; Ulrich Pfeffer, PhD; Carlo Mosci, MD; Martine J. Jager, MD, PhD; Silvano Ferrini, MD; Rosaria Gangemi, MD

Importance  Conventional melanoma serum biomarkers (S100 and lactate dehydrogenase [LDH]) perform poorly in patients with uveal melanoma, and the search for new biomarkers is needed. A high expression of the oncoprotein c-Met in primary uveal melanoma is associated with metastatic progression, and c-Met is released as a ...

Brief Report 
Mark C. Gillies, PhD, FRANZCO; Hemal Mehta, MA, FRCOphth; Alan C. Bird, MD, FRCOphth
Includes: Supplemental Content

Importance  Macular telangiectasia type 2 is a bilateral disease with characteristic alterations of the macular capillary network and neural atrophy. Vascular and neurodegenerative hypotheses have been proposed to explain these clinical findings, but many questions regarding the pathogenesis remain.

Observations  We report the case of a ...

Research Letter 
Friederike Schaub, MD; Claus Cursiefen, MD; Ludwig M. Heindl, MD

This study evaluates split-cornea transplantation, which uses donor tissue for deep anterior lamellar keratoplasty in one patient and Descemet membrane endothelial keratoplasty in another patient.

Johannes Keller, FRCOphth; Richard J. Haynes, MD, FRCOphth

Ocriplasmin is a recombinant fraction of plasmin with nonspecific protease activity capable of cleaving fibronectin and laminin. It has recently been approved for the treatment of vitreomacular traction and associated macular holes (MHs). Clinical trials1 report good clinical results and safety profile. We report 2 cases that ...

Original Investigation 
Jacqueline Chua, PhD; Mani Baskaran, MD; Peng Guan Ong, BSc; Yingfeng Zheng, MD, PhD; Tien Yin Wong, FRCS, PhD; Tin Aung, FRCS(Ed), PhD; Ching-Yu Cheng, MD, PhD
Includes: Supplemental Content

Importance  Glaucoma can remain asymptomatic until a severe stage, resulting in a high prevalence of undiagnosed glaucoma worldwide. Asia accounts for 60% of the world’s total glaucoma cases. To our knowledge, no epidemiological studies have assessed ethnic differences in undiagnosed glaucoma among various Asian subgroups.

Objective  ...

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