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Basic View | Expanded View
 Showing 1-20 of 61 Articles
Viewpoint 
Christine Shieh, MD; Gargi Vora, MD; Terry Kim, MD
This Viewpoint reports on Ebola virus disease and the current Ebola epidemic, which has been deemed the largest in history.
Editorial 
Michael V. Boland, MD, PhD
The Health Information Technology for Economic and Clinical Health Act adopted in 2009 was designed to increase the use of electronic health records (EHRs) by US health care professionals and hospitals via a system of incentive payments. As of December 2014, almost 340 000 professionals received these payments via Medicare ...
Original Investigation 
Rishi P. Singh, MD; Rumneek Bedi, BS; Ang Li, BS; Sharmila Kulkarni, BS; Tiffany Rodstrom, COT, RN; Gene Altus, BA, MBA; Daniel F. Martin, MD
Includes: Supplemental Content

Importance  Given the lack of previous reports examining the impact of electronic health record (EHR) system migration in ophthalmology, a study evaluating the practice and economic effect of implementing an EHR into an ophthalmic practice is warranted.

Objective  To examine the clinical and economic impact of ...

Editorial: Electronic Health Records and Ophthalmology; Michael V. Boland, MD, PhD
Original Investigation 
Hidenobu Tanihara, MD; Toshihiro Inoue, MD; Tetsuya Yamamoto, MD; Yasuaki Kuwayama, MD; Haruki Abe, MD; Hideki Suganami, PhD; Makoto Araie, MD; for the K-115 Clinical Study Group
Includes: Supplemental Content

Importance  Ripasudil hydrochloride hydrate (K-115), a novel rho kinase inhibitor, provides statistically significant intraocular pressure (IOP)–lowering effects and has a tolerable safety profile. However, no studies have evaluated ripasudil combined with β-blockers and prostaglandin analogues.

Objective  To evaluate the additive IOP-lowering effects and the safety of ...

Original Investigation 
James T. Rosenbaum, MD; Dongseok Choi, PhD; David J. Wilson, MD; Hans E. Grossniklaus, MD; Christina A. Harrington, PhD; Cailin H. Sibley, MD; Roger A. Dailey, MD; John D. Ng, MD; Eric A. Steele, MD; Craig N. Czyz, MD; Jill A. Foster, MD; David Tse, MD; Chris Alabiad, MD; Sander Dubovy, MD; Prashant Parekh, MD; Gerald J. Harris, MD; Michael Kazim, MD; Payal Patel, MD; Valerie White, MD; Peter Dolman, MD; Bobby S. Korn, MD; Don Kikkawa, MD; Deepak P. Edward, MD; Hind Alkatan, MD; Hailah al-Hussain, MD; R. Patrick Yeatts, MD; Dinesh Selva, MBBS, FRANZCO, FRACS; Patrick Stauffer, BA; Stephen R. Planck, PhD
Includes: Supplemental Content

Importance  Sarcoidosis is a major cause of ocular or periocular inflammation. The pathogenesis of sarcoidosis is incompletely understood and diagnosis often requires a biopsy.

Objective  To determine how gene expression in either orbital adipose tissue or the lacrimal gland affected by sarcoidosis compares with gene expression ...

Original Investigation 
Daniela Ferrara, MD, PhD; Johanna M. Seddon, MD, ScM
Includes: Supplemental Content

Importance  The complement factor H R1210C rare variant confers the strongest genetic risk for age-related macular degeneration and earlier age at onset; however, its associated phenotype has not been well characterized.

Objective  To describe specific fundus features of a white population with the R1210C rare variant....

Observation 
Jessica R. Chang, MD; Michael P. Grant, MD, PhD; Shannath L. Merbs, MD, PhD
Functional endoscopic sinus surgery (FESS) is a commonly performed procedure that has a risk of serious ophthalmic complications. We report a case of complete enucleation as a complication of FESS.
Viewpoint 
Aaron Nagiel, MD, PhD; SriniVas R. Sadda, MD; David Sarraf, MD
This Viewpoint reports on optical coherence tomography angiography and how its use could greatly enrich our understanding of the ischemic processes affecting different layers of the retinal vasculature.
Original Investigation 
Caitlin L. M. Kakigi, BA; Kuldev Singh, MD, MPH; Sophia Y. Wang, MD; Wayne T. Enanoria, PhD, MPH; Shan C. Lin, MD
Includes: Supplemental Content

Importance  Despite widespread use of calcium supplementation among elderly people, little is known about the association between such consumption and the prevalence of age-related macular degeneration (AMD) in the United States.

Objective  To investigate the association between self-reported supplementary calcium consumption and the prevalence of AMD ...

Original Investigation 
Judith E. Goldstein, OD; Mary Lou Jackson, MD; Sandra M. Fox, OD; James T. Deremeik, CLVT; Robert W. Massof, PhD; for the Low Vision Research Network Study Group

Importance  To facilitate comparative clinical outcome research in low vision rehabilitation, we must use patient-centered measurements that reflect clinically meaningful changes in visual ability.

Objective  To quantify the effects of currently provided low vision rehabilitation (LVR) on patients who present for outpatient LVR services in the ...

Observation 
Stéphanie Hayek, MD; Antoine Rousseau, MD; Elise Bouthry, MD; Christine M. Prat, PhD; Marc Labetoulle, MD, PhD
Chikungunya virus (CHIKV) is a mosquito-borne viral disease caused by an arbovirus from the Togaviridae family. It is endemic in parts of Africa and Southeast Asia and on the Indian subcontinent.1 In December 2013, autochthonous chikungunya cases were confirmed on Saint-Martin island in the French West Indies. This was the ...
Original Investigation 
Karla Zadnik, OD, PhD; Loraine T. Sinnott, PhD; Susan A. Cotter, OD, MS; Lisa A. Jones-Jordan, PhD; Robert N. Kleinstein, OD, MPH, PhD; Ruth E. Manny, OD, PhD; J. Daniel Twelker, OD, PhD; Donald O. Mutti, OD, PhD; for the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study Group

Importance  Myopia (nearsightedness) has its onset in childhood and affects about one-third of adults in the United States. Along with its high prevalence, myopia is expensive to correct and is associated with ocular diseases that include glaucoma and retinal detachment.

Objective  To determine the best set ...

Original Investigation 
Nichole D. L. Joachim, BSc(Hons); Paul Mitchell, MD, PhD; Annette Kifley, MAppStats, PhD; Jie Jin Wang, MMed, PhD

Importance  The natural course and prognosis of medium drusen and risk factors associated with the incidence and progression of this lesion type in age-related macular degeneration (AMD) are not well understood.

Objective  To assess the 15-year incidence and progression of medium drusen and associated risk factors....

Importance  Retinal hemorrhages are an important sequela of fatal head trauma. The accurate pathologic diagnosis of retinal hemorrhages has critical implications for determination of the manner of death.

Observations  We describe an autolytic postmortem histologic artifact of eosinophilic Müller cell foot process swelling that mimics a ...

Comment & Response 
Swapna S. Shanbhag, MS; Abhishek Hoshing, DNB; Sayan Basu, MBBS, MS
To the Editor We read with great interest the article by Monnereau et al1 in which the authors reported the clinical outcomes of the initial Descemet membrane endothelial keratoplasty (DMEK) procedures performed by experienced corneal surgeons using a standardized “no-touch” surgical technique.2 They concluded that DMEK was feasible in most ...
Comment & Response 
Claire Monnereau, MSc; Isabel Dapena, MD, PhD; Gerrit R. J. Melles, MD, PhD
In Reply We thank Shanbhag et al for commenting on our study. In short, they question whether, based on our article describing the learning curve for 18 novel DMEK surgeons,1 the procedure would be a better alternative to DSEK and PK. The main concerns expressed are that the study does ...
Original Investigation 
Vatinee Y. Bunya, MD; Nicole M. Fuerst, MD; Maxwell Pistilli, MEd, MS; Bridgette E. McCabe, BS; Rebecca Salvo, BA; Ilaria Macchi, MD; Gui-Shuang Ying, PhD; Mina Massaro-Giordano, MD
Includes: Supplemental Content

Importance  Knowledge about the variability of measurements using the TearLab Osmolarity System is necessary when evaluating the clinical utility of readings.

Objective  To examine the variability of tear osmolarity measured by the TearLab Osmolarity System in patients with Sjögren syndrome (SS), patients with blepharitis, and control ...

Original Investigation 
Ebenezer Daniel, MBBS, MS, MPH, PhD; Graham E. Quinn, MD, MSCE; P. Lloyd Hildebrand, MD; Anna Ells, MD, FRCS(C); G. Baker Hubbard III, MD; Antonio Capone Jr, MD; E. Revell Martin, BA; Candace P. Ostroff, BA; Eli Smith, BA; Maxwell Pistilli, MS; Gui-Shuang Ying, PhD; for the e-ROP Cooperative Group
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Measurable competence derived from comprehensive and advanced training in grading digital images is critical in studies using a reading center to evaluate retinal fundus images from infants at risk for retinopathy of prematurity (ROP). Details of certification for nonphysician trained readers (TRs) have not yet been ...

Original Investigation 
Julia S. Steinberg, MD; Fred W. Fitzke, PhD; Rolf Fimmers, PhD; Monika Fleckenstein, MD; Frank G. Holz, MD; Steffen Schmitz-Valckenberg, MD, FEBO
Includes: Supplemental Content

Importance  Clinical observations suggest that patients with age-related macular degeneration (AMD) have vision problems, particularly in dim light conditions. Previous studies on structural-functional analysis in patients with AMD with reticular drusen (RDR) have focused on photopic sensitivity testing but have not specifically assessed scotopic function.

Objective  ...

New Instrument 
Ehsan Rahimy, MD; Sunir J. Garg, MD
Includes: Supplemental Content
This Clinical Review describes the experience of using Google Glass to record scleral buckling surgery and discusses its potential use in medical education.

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