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 Showing 1-20 of 59 Articles
Original Investigation 
Farzana Choudhury, MBBS, MS, PhD; Rohit Varma, MD, MPH; Ronald Klein, MD, MPH; W. James Gauderman, PhD; Stanley P. Azen, PhD; Roberta McKean-Cowdin, PhD; for the Los Angeles Latino Eye Study Group
Includes: Supplemental Content

Importance  This study found evidence of a threshold effect in which the presence of bilateral soft drusen and depigmentation of retinal pigment epithelium was associated with substantially low health-related quality of life (HRQoL) in adult Latinos from the United States.

Objective  To assess the association of ...

Invited Commentary: Patient-Reported Outcomes for Clinical Decision Making ; Päivi H. Miskala, PhD
Original Investigation 
Christina L. Decatur, BS; Erin Ong, BS, BA; Nisha Garg, BS; Hima Anbunathan, MS; Anne M. Bowcock, PhD; Matthew G. Field, MS; J. William Harbour, MD
Includes: Supplemental Content

Importance  Frequent mutations have been described in the following 5 genes in uveal melanoma (UM): BAP1, EIF1AX, GNA11, GNAQ, and SF3B1. Understanding the prognostic significance of these mutations could facilitate their use in precision medicine.

Objective  To determine the associations between ...

Invited Commentary: Prognostication of Uveal Melanoma; Arun D. Singh, MD
Original Investigation 
Scott D. Walter, MD; Daniel L. Chao, MD, PhD; William Feuer, MS; Joyce Schiffman, MS; Devron H. Char, MD; J. William Harbour, MD
Includes: Supplemental Content

Importance  Uveal melanoma (UM) can be divided into prognostically significant subgroups based on a prospectively validated and widely used 15-gene expression profile (GEP) test. Class 1 UMs have a low risk and class 2 UMs have a high risk for metastasis.

Objective  To determine whether any ...

Invited Commentary: Prognostication of Uveal Melanoma; Arun D. Singh, MD

The US Food and Drug Administration published a draft guidance document in 2006, which was finalized in 2009, that established the regulatory standards for development, validation, and use of patient-reported outcome (PRO) measures to support medical product–labeling claims regarding treatment benefit (ie, efficacy or comparative safety).1 The ...

Invited Commentary 
Arun D. Singh, MD

In this issue of JAMA Ophthalmology, 2 articles1,2 address important aspects of melanoma: pathogenesis (driver mutations), prognostication, and survival. Genetic alterations detected in the primary tumor by chromosomal tests (fluorescence in situ hybridization), DNA-based tests (single-nucleotide polymorphism and multiplex ligation–dependent probe amplification), and RNA-based ...

JAMA Ophthalmology Clinical Challenge 
Landon C. Meekins, MD; Pradeep Mettu, MD; M. Tariq Bhatti, MD

A man in his 20s presents with decreased vision in the left eye that was associated with intermittent left orbital pain that does not improve with 2 weeks of oral corticosteroids. What would you do next?

Observation 
Thomas A. Eldredge, MBBS; Saul N. Rajak, PhD, FRCOphth; Ajay Taranath, MBBS, MD , FRANZCR; Dinesh Selva, MBBS, FRANZCO

This report describes a case of proptosis secondary to remodeling of the orbital bones in a patient with intracranial hypertension from acute lymphoblastic leukemia.

Original Investigation 
Hassan A. Aziz, MD; Nakul Singh, MS; James Bena, MS; Allan Wilkinson, PhD; Arun D. Singh, MD
Includes: Supplemental Content

Importance  Vision loss following episcleral brachytherapy for uveal melanoma is difficult to predict for individual patients.

Objective  To generate a risk calculator for vision loss following episcleral brachytherapy for uveal melanoma.

Design, Setting, and Participants  A retrospective review of data was conducted at a multispecialty ...

Original Investigation 
Ashvini K. Reddy, MD; Gregory W. Bounds, BS; Sophie J. Bakri, MD; Lynn K. Gordon, MD, PhD; Justine R. Smith, FRANZCO, PhD; Julia A. Haller, MD; Jennifer E. Thorne, MD, PhD

Importance  Women in ophthalmology are growing in number and have made strides in traditional metrics of professional achievement. Professional ties to industry represent another potential means of career advancement, recognition, and income.

Objective  To report the representation of women among ophthalmologists receiving industry remuneration for research, ...

Original Investigation 
Maureen G. Maguire, PhD; Gui-shuang Ying, PhD; Glenn J. Jaffe, MD; Cynthia A. Toth, MD; Ebenezer Daniel, MBBS, PhD; Juan Grunwald, MD; Daniel F. Martin, MD; Stephanie A. Hagstrom, PhD; for the CATT Research Group
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Single-nucleotide polymorphisms (SNPs) associated with the CFH, ARMS2, C3, LIPC, CFB, and C2 genes are associated with age-related macular degeneration (AMD); however, the association of these SNPs with angiographic features of neovascular AMD has been inconsistent in previous studies, and to ...

Invited Commentary 
Itay Chowers, MD

Age-related macular degeneration (AMD) is a multifactorial disease with a strong genetic basis. In recent years, the study of AMD genetics experienced a major advance; as a result, variants in more than 30 genes have been associated with AMD. It has been estimated that genetics contribute at least ...

JAMA Ophthalmology Clinical Challenge 
Harpal Singh Sandhu, MD; Albert M. Maguire, MD

A man in his 60s presented with decreased visual acuity in the right eye, a history of human immunodeficiency virus infection, and retinal detachment of the left eye secondary to cytomegalovirus retinitis. What would you do next?

Comment & Response 
Simar Rajan Singh, MS; Ramandeep Singh, MS

To the Editor In their Viewpoint, Gross and Glassman1 have concluded that intravitreal anti–vascular endothelial growth factor (anti-VEGF) is noninferior to panretinal photocoagulation (PRP) in the treatment of proliferative diabetic retinopathy (PDR). We have a few concerns about this approach of using anti-VEGF for PDR.

Comment & Response 
Jeffrey G. Gross, MD; Adam R. Glassman, MS

In Reply Singh and Singh state that the development or worsening of TRD as a result of preretinal fibrosis is a potential complication of anti-VEGF therapy in the setting of PDR based on description from a few case series or retrospective reports. Eyes with PDR are inherently at ...

Original Investigation 
J. Peter Campbell, MD, MPH; Esra Ataer-Cansizoglu, PhD; Veronica Bolon-Canedo, PhD; Alican Bozkurt, MSc; Deniz Erdogmus, PhD; Jayashree Kalpathy-Cramer, PhD; Samir N. Patel, BS; James D. Reynolds, MD; Jason Horowitz, MD; Kelly Hutcheson, MD; Michael Shapiro, MD; Michael X. Repka, MD, MBA; Phillip Ferrone, MD; Kimberly Drenser, MD; Maria Ana Martinez-Castellanos, MD; Susan Ostmo, MS; Karyn Jonas, RN; R.V. Paul Chan, MD; Michael F. Chiang, MD; for the Imaging and Informatics in ROP (i-ROP) Research Consortium

Importance  Published definitions of plus disease in retinopathy of prematurity (ROP) reference arterial tortuosity and venous dilation within the posterior pole based on a standard published photograph. One possible explanation for limited interexpert reliability for a diagnosis of plus disease is that experts deviate from the published ...

Original Investigation 
Eugene A. Lowry, MD; Alejandra G. de Alba Campomanes, MD, MPH
Includes: Supplemental Content

Importance  Many preschool visual screening programs incorporate school-based comprehensive examinations, but the follow-up rates and cost-effectiveness of this approach are not well studied.

Objective  To determine the follow-up rates and cost-effectiveness of referral to community-based eye care professionals vs to a mobile eye examination unit (mobile ...

Invited Commentary: Enhancing the Value of Preschool Vision Screenings; Eric L. Ross, BA; Joshua D. Stein, MD, MS
Original Investigation 
Mala Subash, BM, FRCOphth; Oliver Comyn, MD(Res), FRCOphth; Ahmed Samy, MSc, FRCS(Glasgow); Dania Qatarneh, FRCOphth; Serafeim Antonakis, MD, MA; Manjit Mehat, MBChB, MSc; James Tee, MA, FRCOphth; Tatiana Mansour, MD; Wen Xing, MSc; Catey Bunce, DSc; Ananth Viswanathan, MD, PhD, FRCOphth; Gary Rubin, PhD; Richard Weleber, MD; Tunde Peto, MD, PhD; Louisa Wickham, FRCOphth; Michel Michaelides, MD, FRCOphth
Includes: Supplemental Content

Importance  Panretinal photocoagulation (PRP) for proliferative diabetic retinopathy (PDR) may lead to peripheral field loss that prevents driving. Anti–vascular endothelial growth factor agents are proposed as treatments for PDR that spare peripheral vision. If multispot lasers cause less visual field loss, continuing to perform PRP may be ...

Invited Commentary: Driving Eligibility in Proliferative Diabetic Retinopathy; Cynthia Owsley, PhD, MSPH; Gerald McGwin Jr, MS, PhD
Invited Commentary 
Cynthia Owsley, PhD, MSPH; Gerald McGwin Jr, MS, PhD

In this issue of JAMA Ophthalmology, Subash et al1 report that most of their study participants who underwent bilateral multispot laser panretinal photocoagulation (PRP) for proliferative diabetic retinopathy (PDR) met the visual field standard for holding a car or motorcycle license in the United Kingdom 6 ...

Invited Commentary 
Eric L. Ross, BA; Joshua D. Stein, MD, MS

In this issue of JAMA Ophthalmology, Lowry and de Alba Campomanes1 present findings of a study comparing the cost-effectiveness of 2 approaches to follow-up examinations of children who fail preschool vision screenings: the use of a mobile eye examination unit (mobile follow-up) staffed by eye care ...

JAMA Ophthalmology Clinical Challenge 
Megan M. Tuohy, BS; Ta C. Chang, MD; Kara M. Cavuoto, MD

An adolescent boy was referred to the emergency department for suspected herpes zoster infection by his pediatrician after presenting with a 2-day history of painful, left-sided vesicular rash around his eyelid and forehead. What would you do next?

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