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 Showing 1-20 of 65 Articles
Original Investigation  FREE
Justis P. Ehlers, MD; Jeff Goshe, MD; William J. Dupps, MD, PhD; Peter K. Kaiser, MD; Rishi P. Singh, MD; Richard Gans, MD; Jonathan Eisengart, MD; Sunil K. Srivastava, MD
Includes: Supplemental Content

Importance  Optical coherence tomography (OCT) has transformed the clinical management of a myriad of ophthalmic conditions. Applying OCT to ophthalmic surgery may have implications for surgical decision making and patient outcomes.

Objective  To assess the feasibility and effect on surgical decision making of a microscope-integrated intraoperative ...

Invited Commentary: Intraoperative Optical Coherence Tomography; Sebastian Siebelmann, MD; Philipp Steven, MD; Claus Cursiefen, MD
Original Investigation 
Wolfgang A. Schrems, MD; Laura M. Schrems-Hoesl, MD; Delia Bendschneider, MD; Christian Y. Mardin, MD; Robert Laemmer, MD; Friedrich E. Kruse, MD; Folkert K. Horn, PhD
Includes: Supplemental Content

Importance  New methods are needed to compare peripapillary retinal nerve fiber layer thickness (pRNFLT) measurements taken from time-domain optical coherence tomography (TD-OCT) and spectral-domain OCT (SD-OCT).

Objective  To compare the agreement of measured and predicted pRNFLT using different equations based on pRNFLT measurements obtained by TD-OCT ...

Brief Report 
David C. Wong, MD; Michael D. Waxman, MD; Lisa J. Herrinton, PhD; Neal H. Shorstein, MD

Importance  Intracameral injection of cefuroxime sodium (1 mg/0.1 mL) has been reported to reduce the risk of endophthalmitis following cataract surgery. In the United States it must be compounded, which is subject to dilution error. We describe a series of 13 eyes that received intracameral injection of ...

Invited Commentary 
Sebastian Siebelmann, MD; Philipp Steven, MD; Claus Cursiefen, MD

In recent years, optical coherence tomography (OCT) has developed into one of the most important imaging techniques in ophthalmology. Nonetheless, this technology is still evolving rapidly as recent developments in multimodal swept-source OCT devices and 4-dimensional real-time OCT demonstrate.

JAMA Ophthalmology Clinical Challenge 
Avni V. Patel, MD, MBA; Thanos D. Papakostas, MD; Demetrios G. Vavvas, MD, PhD

A man in his 30s with recent diagnosis of human immunodeficiency virus infection presents with a 5-day history of bilateral redness, blurred vision, and photophobia. What would you do next?

Research Letter 
Ahmad Al-Moujahed, MD; James Chodosh, MD, MPH

This case series evaluates the results of following a clinical algorithm to treat mild ocular alkali burns.

Ian C. Han, MD; Lawrence J. Singerman, MD; Alvin Schmaier, MD; Neil M. Bressler, MD

This case report describes a patient with common variable immunodeficiency who developed bilateral, multiple, episodic retinal vein occlusions.

Viewpoint  FREE
Lee M. Jampol, MD; Frederick L. Ferris III, MD; Rachel J. Bishop, MD, MPH

This Viewpoint discusses how the Ebola virus affects the eye.

Original Investigation 
Liang Liu, MD; Yali Jia, PhD; Hana L. Takusagawa, MD; Alex D. Pechauer, BS; Beth Edmunds, MD, PhD; Lorinna Lombardi, MD; Ellen Davis, MD; John C. Morrison, MD; David Huang, MD, PhD

Importance  Vascular factors may have important roles in the pathophysiology of glaucoma. A practical method for the clinical evaluation of ocular perfusion is needed to improve glaucoma management.

Objective  To detect peripapillary retinal perfusion in glaucomatous eyes compared with normal eyes using optical coherence tomography (OCT) ...

Invited Commentary: Measuring Blood Flow; Joel S. Schuman, MD
Original Investigation 
Michael T. Tetzlaff, MD, PhD; Jonathan L. Curry, MD; Vivian Yin, MD; Penvadee Pattanaprichakul, MD; Jane Manonukul, MD; Mongkol Uiprasertkul, MD; Ganiraju C. Manyam, MS; Khalida M. Wani, PhD; Kenneth Aldape, MD, PhD; Li Zhang, PhD; Victor G. Prieto, MD, PhD; Bita Esmaeli, MD

Importance  The molecular-genetic alterations contributing to the pathogenesis of sebaceous carcinoma and sebaceous adenoma remain poorly understood. Given that sebaceous carcinoma is associated with substantial morbidity and mortality, there is a critical need to delineate the pathways driving sebaceous carcinoma and candidate molecules for targeted therapy.


Original Investigation 
Lili Zhang, MD, PhD; Zhitao Su, MD, PhD; Zongduan Zhang, MD, PhD; Jing Lin, MD, PhD; De-Quan Li, MD, PhD; Stephen C. Pflugfelder, MD
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Topical application of azithromycin suppresses expression of proinflammatory mediators while restoring transforming growth factor β1 (TGF-β1) levels as evaluated by eyelid margin and conjunctival impression cytology.

Objective  To explore the effects of azithromycin therapy on expression of proinflammatory and anti-inflammatory mediators in meibomian gland disease ...

Invited Commentary 
Joel S. Schuman, MD

Ocular blood flow and optic nerve injury have been linked and have remained in a chicken-and-egg quandary since the 19th century. The question of which comes first remains unanswered, and the connection has not been revealed.

Original Investigation  FREE
Ronald Klein, MD, MPH; Chelsea E. Myers, MStat; Kristine E. Lee, MS; Andrew D. Paterson, MBChB; Karen J. Cruickshanks, PhD; Michael Y. Tsai, PhD; Ronald E. Gangnon, PhD; Barbara E. K. Klein, MD, MPH
Includes: Supplemental Content

Importance  Studies have shown oxidized low-density lipoprotein to be associated with the incidence of proliferative retinopathy and other complications of type 1 diabetes mellitus. Because low-risk interventions are available to modify oxidized low-density lipoprotein, it is important to examine the relationships between this factor and the incidence ...

Original Investigation 
Nicolas Alessandro Yannuzzi, MD; Jasmine H. Francis, MD; Brian P. Marr, MD; Irina Belinsky, MD; Ira J. Dunkel, MD; Yves Pierre Gobin, MD; David Harold Abramson, MD

Importance  Ophthalmic artery chemosurgery (OAC) has emerged as a primary treatment for advanced-stage retinoblastoma. To our knowledge, the incidence of orbital recurrence in eyes treated with OAC has not been described.

Objective  To determine the incidence of orbital recurrence following enucleation or OAC as primary treatments ...

Brief Report 
Kevin Gallagher, BMBCh, FRCOphth; Ananth Viswanathan, FRCOphth; Narciss Okhravi, FRCOphth, PhD
Includes: Supplemental Content

Importance  Systemic lupus erythematosus (SLE) can be associated with uveitis. The reported prevalence of SLE in patients with uveitis varies from 0.1% to 4.8%. Accordingly, the positive predictive value of antinuclear antibody testing in diagnosing SLE in a patient with uveitis varies enormously. An accurate estimate of ...

JAMA Ophthalmology Clinical Challenge 
Sotiria Palioura, MD, PhD; Neda Nikpoor, MD; Sonia H. Yoo, MD

A 10-year-old boy presents with a 6-month history of intermittent redness, swelling, and itching of the right eye and multiple raised papules on the face, elbow, and knee. What Would You Do Next?

Original Investigation  FREE
Fabio Scarinci, MD; Lee M. Jampol, MD; Robert A. Linsenmeier, PhD; Amani A. Fawzi, MD

Importance  Diabetic macular nonperfusion leads to decreased perifoveal capillary blood flow, which in turn causes chronic ischemia of the retinal tissue. Using point-to-point correlation between spectral-domain optical coherence tomography (SD-OCT) and nonperfusion on fluorescein angiography, we observed that retinal capillary nonperfusion is associated with photoreceptor compromise on ...

Brief Report 
Richard J. Symes, BSc(Hons), FRCOphth; Mahyar Etminan, PharmD, MSc; Frederick S. Mikelberg, MD, FRCSC

Importance  Epidemiologic studies have shown that antidepressants may increase the risk of angle-closure glaucoma. We examined the risk of angle-closure glaucoma with bupropion hydrochloride, a unique, popular antidepressant also marketed as a smoking cessation aid.

Observations  A nested case-control study was conducted using a large health ...

JAMA Ophthalmology Clinical Challenge 
Kai B. Kang, MD; Jennifer I. Lim, MD

A woman in her early 40s with a history of recurrent meningioma of the right sphenoid wing after tumor resections, followed by adjuvant radiation, presented with fluctuating vision in the right eye for several months. Her best-corrected visual acuity was 20/20 OD and 20/20 OS. What would you ...

Research Letter  FREE
Scott M. McClintic, MD; Yali Jia, PhD; David Huang, MD, PhD; Steven T. Bailey, MD

This case report describes the use of optical coherence tomographic angiography to detect choroidal neovascularization.

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