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 Showing 1-20 of 68 Articles
Since the beginning of neovascular age-related macular degeneration (AMD) therapy, clinicians have been faced with a dilemma—that treatment was most helpful if choroidal neovascularization (CNV) was detected before visual acuity was affected1 but that identifying patients at this early stage was difficult. Self-detection techniques have been less than satisfactory. For ...
Original Investigation 
Diabetic Retinopathy Clinical Research Network Writing Committee
Includes: Supplemental Content

Importance  Understanding measurement variability and relationships between measurements obtained on different optical coherence tomography (OCT) machines is critical for clinical trials and clinical settings.

Objective  To evaluate the reproducibility of retinal thickness measurements from OCT images obtained by time-domain (TD) (Stratus; Carl Zeiss Meditec) and spectral-domain ...

Original Investigation 
Jessica M. Skeie, PhD; Vinit B. Mahajan, MD, PhD
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Differences in geographical protein expression in the human choroid–retinal pigment epithelial (RPE) complex may explain molecular predisposition of regions to ophthalmic diseases such as age-related macular degeneration.

Objective  To characterize the proteome of the human choroid-RPE complex and to identify differentially expressed proteins in specific ...

Topics: pigment; choroid
Original Investigation 
Marie Thulliez, MD; Denis Angoulvant, MD, PhD; Marie Laure Le Lez, MD; Annie-Pierre Jonville-Bera, MD; Pierre-Jean Pisella, MD, PhD; François Gueyffier, MD, PhD; Theodora Bejan-Angoulvant, MD, PhD
Includes: Supplemental Content

Importance  Few data exist regarding the systemic safety of intravitreal antivascular endothelial growth factor (anti-VEGF) monoclonal antibody (mAb).

Objective  To conduct a systematic review and meta-analysis to evaluate the risk of major cardiovascular and nonocular hemorrhagic events in patients with neovascular age-related macular degeneration (AMD), diabetes ...

Original Investigation 
Jennifer K. Sun, MD, MPH; Michael M. Lin, BA; Jan Lammer, MD; Sonja Prager, MD; Rutuparna Sarangi, BA; Paolo S. Silva, MD; Lloyd Paul Aiello, MD, PhD
Includes: Supplemental Content

Importance  Biomarkers that predict future visual acuity (VA) in eyes with baseline diabetic macular edema (DME) would substantively improve risk assessment, management decisions, and selection of eyes for clinical studies targeting DME.

Objective  To determine whether baseline or early change in the novel spectral domain–optical coherence ...

Ehsan Rahimy, MD; Nadim Rayess, MD; Christine L. Talamini, MD; Richard S. Kaiser, MD
Prepapillary vascular loops are a congenital anomaly characterized as having both an ascending and a descending branch, and they are thought to be arterial in origin in 95% of cases.1,2 As such, complications that may spontaneously arise include branch retinal artery occlusion (BRAO) and, less commonly, amaurosis fugax, vitreous hemorrhage, ...
Ophthalmic Images 
Ruwan A. Silva, MD; Robert T. Chang, MD; Darius M. Moshfeghi, MD; Theodore Leng, MD, MS
Graphic Jump LocationA, Posterior segment photograph of the left eye demonstrating a large inferotemporal optic nerve pit. Pigmentary mottling of the choroid is also noted. B, Spectral-domain optical coherence tomography through the optic pit reveals an associated choroidal cleft.
Topics: eye; optic nerve
Ophthalmic Images 
Christina Gerth-Kahlert, MD; Rike Michels, MD; Jens Funk, MD; Ursula Gautschy, OT
Graphic Jump LocationColor anterior segment imaging showing a bilateral congenital lamellar cataract in a 6.5-year-old girl (visual acuity, 20/70). Small central opacification and peculiar posterior disruption of the cortical alignment are visible in both the right eye (A) and the left eye (B). Visual acuity improved to 20/25 in both ...
Topics: cataract; eye
Brief Report 
Cheryl E. Sherrod, MD, MPH; Susan Vitale, PhD, MHS; Kevin D. Frick, PhD; Pradeep Y. Ramulu, MD, MHS, PhD

Importance  Working is critical to personal health and well-being. We examine the association of vision measured objectively with work status using a nationally representative sample of working-age Americans.

Observation  A total of 19 849 participants from the 1999-2008 National Health and Nutrition Examination Survey completed a vision ...

Mircea N. Coca, MD, PhD; Sohrab Tofigh, MD; Ahmed Elkeeb, MD; Bernard F. Godley, MD, PhD, MBA
Optic disc pit (ODP) is a rare congenital cavitation in the optic nerve head frequently associated with serous detachments of the macula, ODP maculopathy (ODP-M), and subsequent visual decline.1 Optic disc pit maculopathy is preceded by development of a schisis cavity due to accumulation of intraretinal fluid from the ODP. ...
David R. Lally, MD; Jay S. Duker, MD; John E. Mignano, MD, PhD; Stephen Martin, MD; Andre J. Witkin, MD
Includes: Supplemental Content
Uveal metastasis is often managed by external beam radiation therapy requiring multiple treatment sessions for the patient. We report the first case, to our knowledge, of regression of choroidal metastasis from breast carcinoma after 1 treatment with Leksell Gamma Knife (GK) stereotactic radiosurgery.

Importance  The cost difference is evaluated between delayed sequential cataract surgery (DSCS) and immediate sequential cataract surgery (ISCS) in the United States for patients covered by Medicare.

Objective  To perform a cost-minimization analysis comparing ISCS with DSCS in the United States from the payer, patient, and ...

Original Investigation 
Carol L. Shields, MD; Jeffrey F. McMahon, BS; Hatice T. Atalay, MD; Murat Hasanreisoglu, MD; Jerry A. Shields, MD
Includes: Supplemental Content

Importance  Metastatic tumors of the retina are rare, simulate retinitis, and are associated with poor patient survival.

Objective  To describe the clinical features and outcomes of patients with retinal metastasis from systemic cancer.

Design, Setting, and Participants  Retrospective case series of 8 patients with retinal ...

Original Investigation 
Li-Xia Lou, MD; Kai-Min Hu, MD; Kai Jin, MD; Su-Zhan Zhang, MD, PhD; Juan Ye, MD, PhD
Includes: Supplemental Content

Importance  To date, no consistency exists across studies that have evaluated the relationship between hepatic lipase gene (LIPC) rs10468017 variant and advanced age-related macular degeneration (AMD).

Objective  To summarize all relevant evidence for a relationship between LIPC variant and advanced AMD.

Data Sources  ...

Original Investigation 
Uri Elbaz, MD; Robert Bains, MBChB, FRCS(Plast); Ronald M. Zuker, MD, FRCSC; Gregory H. Borschel, MD; Asim Ali, MD, FRCSC

Importance  Corneal anesthesia is recalcitrant to conventional treatment and can lead to permanent visual loss.

Objective  To assess the outcomes of a novel sensory reconstructive technique for the treatment of corneal anesthesia.

Design, Setting, and Participants  This prospective study evaluating a new technique was conducted ...

Research Letter 
Joon-Bom Kim, BA; Abdallah Jeroudi, MD; Sheila T. Angeles-Han, MD; Hans E. Grossniklaus, MD; Steven Yeh, MD
Sympathetic ophthalmia (SO) is an autoimmune, bilateral, granulomatous panuveitis occurring after accidental or surgical trauma to the eye.1 Systemic corticosteroids are first-line therapy for SO, with immunomodulatory therapy used for corticosteroid-sparing immunosuppression and chronic, refractory cases. Biological response modifiers are a class of therapeutics that target specific cytokines mediating inflammation, ...
Research Letter  FREE
Claudine E. Pang, MD; K. Bailey Freund, MD; Michael Engelbert, MD, PhD
Vitreous degeneration, gradual separation of the posterior vitreous cortex (PVC), and eventual development of posterior vitreous detachment (PVD) are important in vitreoretinal interface diseases. However, determination of the stages of PVD with biomicroscopy or ultrasonography is not sufficiently sensitive and specific.1,2 Since the advent of spectral-domain (SD) optical coherence tomography ...
Samuel G. Jacobson, MD, PhD; Artur V. Cideciyan, PhD; Alexander Sumaroka, PhD; Alejandro J. Roman, MSc; Alan F. Wright, MB, PhD
Two decades ago, a postmortem eye donor study identified a unique autosomal dominant disease and named it late-onset retinal degeneration (L-ORD).1 The distinguishing feature of L-ORD was a retina-wide thick layer of extracellular deposit between the retinal pigment epithelium (RPE) and Bruch membrane. A founder mutation, p.Ser163Arg, in C1QTNF5 was ...
Brief Report 
Joshua H. Hou, MD; Kavitha R. Sivaraman, MD; Jose de la Cruz, MD; Amy Y. Lin, MD; Maria Soledad Cortina, MD

Importance  Retroprosthetic membrane (RPM) formation is the most common complication associated with the Boston type 1 keratoprosthesis and has been associated with corneal melt.

Objective  To identify the histological and immunohistochemical characteristics of RPMs associated with corneal melt.

Design, Setting, and Participants  Observational histopathological case ...

Ophthalmic Images 
Amir A. Azari, MD; Mozhgan Rezaei Kanavi, MD; Pimkwan Jaru-ampornpan, MD; Sherif S. Khedr, MD; Heather D. Potter, MD; Daniel M. Albert, MD; Neal P. Barney, MD
Graphic Jump LocationA 23-year-old man presented with a 2-year history of a slow growing lesion in the left eye. The lesion consisted of a vascularized, balloon-like mass straddling the limbus nasally (A). Histopathologic examination demonstrates (B) a conjunctival epithelium with solar elastosis, consistent with a pterygium (left side), and proliferation ...
Topics: nevus; eye; pterygium

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