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 Showing 1-20 of 93 Articles
Ophthalmic Images 
Neha Mohan, MS; Krushna Gopal Panda, BSc Optom; Tapas Ranjan Padhi, MS
Graphic Jump LocationA 53-year-old man presented with a macular subretinal cystoid abnormality with a whitish central shadow showing contractions during an examination, suggestive of a scolex, and subretinal gliosis extending inferiorly. Ocular cysticercosis was surgically removed, with visual acuity 5 months after surgery of 20/400.
Invited Commentary 
James T. Rosenbaum, MD
Mrs N fidgeted behind me as I focused the slitlamp beam on her daughter’s eye. “Laura has anterior uveitis,” I pronounced.
Comment & Response 
Praveen Kumar Balne, MSc; Soumyava Basu, MS; Savitri Sharma, MD
To the Editor We read with great interest the article by Sharma et al1 on loop-mediated isothermal amplification (LAMP) assay for the rapid diagnosis of tubercular uveitis. The article is very informative and reiterates the utility of this test. However, it is not the first report of using this test ...
Comment & Response 
Kenneth W. Wright, MD
To the Editor The rectus muscle plication is a useful strabismus surgical procedure as reported by Chaudhuri and Demer in the article titled “Surgical Outcomes Following Rectus Muscle Plication: A Potentially Reversible, Vessel-Sparing Alternative to Resection.”1 I first published the rectus plication procedure in 1991 and called it a modified ...
Observation 
Shivali A. Menda, MD; David Palay, MD; Stephen McLeod, MD
The Nd:YAG laser uses infrared light focused at 1064 nm.1 Using a short pulse and high power, it causes plasma formation, resulting in shock or acoustic waves that disrupt target tissue.2,3 It is commonly used for laser periphery iridotomies and posterior capsulotomies. Common complications after Nd:YAG capsulotomy include intraocular pressure ...
Comment & Response 
Kusum Sharma, MBBS, MD; Aman Sharma, MBBS, MD; Amod Gupta, MD
In Reply We appreciate the clarification by Balne and colleagues. Their article did indeed appear in November 2013.1 Perhaps we should have emphasized that before their article had been published, we had presented the content of our later-published work as a peer-reviewed poster at the 2012 Annual Meeting of the ...
Comment & Response 
Zia Chaudhuri, MS, FRCS(Glasg); Joseph L. Demer, MD, PhD
In Reply We thank Dr Wright for his interest in our recent report of surgical outcomes of rectus plication, a comparatively ancient surgical technique deserving reconsideration after having fallen out of favor in the Americas for historical reasons. Tucking and plication are synonymous terms. Plication of rectus extraocular muscles (EOMs) ...
Original Investigation 
Rosa Riveiro-Álvarez, PhD; Yajing (Angela) Xie, MA; Miguel-Ángel López-Martínez, MD; Tomasz Gambin, PhD; Raquel Pérez-Carro, MSc; Almudena Ávila-Fernández, PhD; María-Isabel López-Molina, MD; Jana Zernant, MS; Shalini Jhangiani, PhD; Donna Muzny, MS; Bo Yuan, BS; Eric Boerwinkle, PhD; Richard Gibbs, PhD; James R. Lupski, MD, PhD; Carmen Ayuso, MD, PhD; Rando Allikmets, PhD

Importance  The families evaluated in this study represent the second report of cone-rod dystrophy (CRD) cases caused by mutations in RAB28, a recently discovered gene associated with CRD.

Objective  To determine the disease-causing gene in 2 families of Spanish descent presenting with CRD who do ...

Original Investigation 
Ymkje M. Hettinga, MD; Laura M. E. Scheerlinck, MD; Marc R. Lilien, MD, PhD; Aniki Rothova, MD, PhD; Joke H. de Boer, MD, PhD

Importance  Tubulointerstitial nephritis and uveitis (TINU) syndrome is characterized by tubulointerstitial and ocular inflammation. Thus far, the value of noninvasive diagnostic tests is not known.

Objective  To determine whether urinary β2-microglobulin (β2M), urinary protein, and serum creatinine have predictive value for detecting TINU syndrome in young ...

Ophthalmic Images 
Glenn Yiu, MD, PhD; Thomas J. Cummings, MD; Prithvi Mruthyunjaya, MD
Graphic Jump LocationA and B, A 64-year-old man presented with an elevated, darkly pigmented left conjunctival lesion with leukoplakia and a sentinel vessel (A) with no intraocular involvement on ultrasound biomicroscopy (B). C, Excisional biopsy with double freeze-thaw cryotherapy (Video) showed pigmented epithelioid cells and prominent nucleoli consistent with a ...
Comment & Response 
Devin D. Mackay, MD; Beau B. Bruce, MD, MS; Nancy J. Newman, MD; Valérie Biousse, MD
To the Editor We read with great interest the recent article by Byrd et al1 presenting an innovative method to improve ophthalmic training in medical school. They reported that medical students who voluntarily participated in a community service project (CSP) dedicated to ophthalmic care for the underserved had increased ophthalmology ...
Comment & Response 
Yong-Kyu Kim, MD; Na-Kyung Ryoo, MD; Kyu Hyung Park, MD, PhD
To the Editor We read with interest the recent article by Carle et al1 describing cases of central retinal artery occlusion caused by cosmetic facial filler injection. However, we would like to point out some issues in 2 aspects regarding this article.
Comment & Response 
Michelle Valerie Carle, MD; Richard H. Roe, MD, MHS; Roger Lawrence Novack, MD, PhD
In Reply Much literature has been published for several decades regarding injection sites in and around the facial area for cosmetic and medical reasons, which can result in vision loss or worse consequences.1- 5 The glabella has been reported several times and is in close proximity to the main arterial ...
Original Investigation 
Stacy L. Pineles, MD, MS; Michael X. Repka, MD, MBA; Fei Yu, PhD; Flora Lum, MD; Anne L. Coleman, MD, PhD
Includes: Supplemental Content

Importance  Disorders of binocular vision are increasingly prevalent among fee-for-service Medicare beneficiaries 65 years or older. Visual impairment is a recognized risk factor for fractures. Despite the association of visual impairment and fracture risk, to our knowledge, no study has examined the influence that disorders of binocular ...

Importance  Swedish Interactive Thresholding Algorithm (SITA) testing strategies for the Humphrey Field Analyzer have become a clinical standard. Measurements from SITA Fast are thought to be more variable than SITA Standard, yet some clinics routinely use SITA Fast because it is quicker.

Objective  To examine the ...

Original Investigation 
Ronald E. Gangnon, PhD; Kristine E. Lee, MS; Barbara E. K. Klein, MD, MPH; Sudha K. Iyengar, PhD; Theru A. Sivakumaran, PhD; Ronald Klein, MD, MPH

Importance  Previous studies regarding the severity of age-related macular degeneration (AMD) in 1 eye and its prognostic implications for the fellow eye have focused on the incidence of neovascular AMD in the fellow eye of participants with neovascular AMD in the other eye. It is unclear to ...

Brief Report 
Felipe P. P. Almeida, PhD, MD; Ana Claudia De Lucca, PhD, MD; Ingrid Ursula Scott, MPH, MD; Rodrigo Jorge, PhD, MD; Andre Messias, PhD, MD

Importance  This case report describes a man who developed retinal changes in his right eye associated with brilliant blue G migration into the subretinal space during 2 years of follow-up.

Observation  The patient’s best-corrected visual acuity in the right eye was 20/70 before surgery, and it ...

Ophthalmic Images 
Ehsan Rahimy, MD; James Vander, MD
Graphic Jump LocationA 43-year-old man with a known history of macular telangiectasia type II presented with acute onset of a scalloped-shaped scotoma, which he described as “seeing a seashell” in his right eye. Ophthalmoscopy revealed intraretinal and subretinal macular hemorrhage, and fluorescein angiography demonstrated perifoveal leakage consistent with subretinal neovascularization. ...
Observation 
Eric K. Chin, MD; David R. P. Almeida, MD, MBA, PhD; Bradley A. Sacher, MD; H. Culver Boldt, MD
Oral sunitinib malate (Sutent) is a tyrosine kinase inhibitor that prevents binding of vascular endothelial growth factor and platelet-derived growth factor to their native receptors.1 It has been approved by the US Food and Drug Administration for the treatment of renal cell carcinoma (RCC) and imatinib mesylate–resistant gastrointestinal stromal tumor. ...
Original Investigation 
Lingmin He, MD; Edward E. Manche, MD
Includes: Supplemental Content

Importance  Wavefront-guided (WFG) and wavefront-optimized (WFO) platforms for refractive surgery are designed for improved visual outcomes. It is unclear which treatment profile is superior for patients undergoing photorefractive keratectomy (PRK).

Objective  To compare the safety, efficacy, predictability, stability, and higher-order aberrations in eyes undergoing WFG and ...

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