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 Showing 1-20 of 93 Articles
Original Investigation 
Rebecca I. Chen, BA; Diego T. Barbosa, MD; Chi-Hsin Hsu, MD; Travis C. Porco, PhD, MPH; Shan C. Lin, MD

Importance  Differences in ocular anatomy may contribute to ethnic differences in glaucoma risk. Because the trabecular meshwork (TM) plays an important role in aqueous outflow, its anatomy in relation to at-risk populations may provide insight into a potential contributor to elevated intraocular pressure and thus to probability ...

Original Investigation 
Zhichao Wu, BAppSc(Optom), PhD; Lauren N. Ayton, BOptom, PhD; Chi D. Luu, PhD; Robyn H. Guymer, MBBS, PhD
Includes: Supplemental Content

Importance  There is a need for more sensitive measures of disease in intermediate age-related macular degeneration (AMD) to evaluate novel interventions more effectively and expediently.

Objective  To determine if microperimetry and low luminance visual acuity can detect functional changes over a short duration of follow-up.

Design, ...

Brief Report 
David A. Leske, MS; Jonathan M. Holmes, BM, BCh; B. Michele Melia, ScM; for the Pediatric Eye Disease Investigator Group
Includes: Supplemental Content

Importance  The Intermittent Exotropia Questionnaire (IXTQ) is a patient, proxy, and parental report of quality of life specific to children with intermittent exotropia. We refine the IXTQ using Rasch analysis to improve reliability and validity.

Observation  Rasch analysis was performed on responses of 575 patients with ...

Research Letter 
Harry Petrushkin, FRCOphth; Dhanes Thomas, FRCOphth; Robert Vaughan, PhD; Elli Kondeatis, PhD; Miles R. Stanford, FRCOphth; Clive Edelsten, FRCOphth; Graham R. Wallace, PhD
Idiopathic intermediate uveitis (IIU) is a potentially sight-threatening inflammatory disease characterized by breakdown of the blood-retina barrier with consequent leukocytic infiltration of the vitreous and retina. Poor visual outcome has been associated with cystoid macular edema, poor vision at presentation, and male sex.1 The human leukocyte antigen (HLA) allele DRB1*1501 ...
Observation 
Georgios A. Kontadakis, MD, MSc; Dimitrios Karagiannis, MD, FEBO; Artemios S. Kandarakis, MD, PhD
Lasers used for laser hair removal operate between 700 and 1000 nm to be absorbed by the hair follicle melanin and destroy it by thermal injury. Consequently, there is a theoretical risk of retinal damage due to the high melanin concentration in the retinal pigment epithelium. Thus, ocular protection during ...
Original Investigation 
Yuki Muraoka, MD, PhD; Akitaka Tsujikawa, MD, PhD; Masayuki Hata, MD; Kenji Yamashiro, MD, PhD; Ellabban Abdallah, MD; Ayako Takahashi, MD; Hideo Nakanishi, MD, PhD; Sotaro Ooto, MD, PhD; Teruyo Tanabe, MD, PhD; Nagahisa Yoshimura, MD, PhD
Includes: Supplemental Content

Importance  Paravascular retinal abnormalities are common in highly myopic eyes. However, affected areas may be underestimated, and the pathogenesis and effects on retinal function remain unclear.

Objective  To prospectively investigate the characteristics and pathogenesis of paravascular inner retinal defects (PIRDs).

Design, Setting, and Participants  Prospective ...

Original Investigation 
Xiaoxing Liu, MD; Jingjing Xiao, PhD; Hui Huang, PhD; Liping Guan, PhD; Kanxing Zhao, MD, PhD; Qihua Xu, MD; Xiumei Zhang, PhD; Xinyuan Pan, MD; Shun Gu, PhD; Yanhua Chen, PhD; Jianguo Zhang, PhD; Yulan Shen, PhD; Hui Jiang, PhD; Xiang Gao, PhD; Xiaoli Kang, PhD; Xunlun Sheng, PhD; Xue Chen, PhD; Chen Zhao, MD, PhD
Includes: Supplemental Content

Importance  Inherited retinal dystrophies (IRDs) are a group of retinal degenerative diseases presenting genetic and clinical heterogeneities, which have challenged the genetic and clinical diagnoses of IRDs. Genetic evaluations of patients with IRD might result in better clinical assessments and better management of patients.

Objective  To ...

Research Letter 
Simone L. Li, PhD; Reed M. Jost, MS; Sarah E. Morale, BS; Angie De La Cruz, BS; Lori Dao, MD; David Stager Jr, MD; Eileen E. Birch, PhD
Repeated experience with dichoptic perceptual learning tasks and dichoptic game play have been shown to be effective in improving the visual acuity of amblyopic children and adults.1- 4 However, whether the visual acuity gains achieved with binocular treatment are long lasting has not yet been addressed. We examined the durability ...
Research Letter 
Giuliano Scarcelli, PhD; Sebastien Besner, PhD; Roberto Pineda, MD; Patricia Kalout, MD; Seok Hyun Yun, PhD
Corneal mechanical strength is critical to withstanding intraocular pressure and maintaining normal shape.1,2 In keratoconus, the mechanical stability is compromised,3 which may lead to progressive morphological changes. Therefore, a noninvasive technique capable of accurately measuring the mechanical properties of the cornea may help us understand the mechanism of keratoconus development ...
Observation 
Michael F. Clamp, MD; J. Michael Jumper, MD; H. Richard McDonald, MD; Arthur D. Fu, MD; Brandon J. Lujan, MD
Idiopathic macular hole is a condition widely believed to result from disruption of retinal tissue due to anteroposterior vitreofoveal traction.1 Previous reports have used spectral-domain optical coherence tomography (SD-OCT) to demonstrate cross-sectional images of macular hole formation in the setting of vitreomacular traction.1- 3 Herein, we present sequential en face ...
Original Investigation 
Niloofar Piri, MD; Brooke L. W. Nesmith, MD, JD; Shlomit Schaal, MD, PhD
Includes: Supplemental Content

Importance  The presence of choroidal hyperreflective foci in Stargardt disease is, to our knowledge, a potentially new finding. Evaluation of these foci may aid in better understanding of the disease process.

Objectives  To report the presence of choroidal hyperreflective foci in spectral-domain optical coherence tomography (SD-OCT) ...

Original Investigation 
Seyhan Yazar, MOrth; Gabriel Cuellar-Partida, BSci; Charlotte M. McKnight, MBBS; Piriya Quach-Thanissorn; Jenny A. Mountain, MBA; Minas T. Coroneo, MD, MS; Craig E. Pennell, FRANZCOG; Alex W. Hewitt, FRANZCO; Stuart MacGregor, PhD; David A. Mackey, FRANZCO

Importance  Conjunctival UV autofluorescence (CUVAF) photography was developed to detect and characterize preclinical sunlight-induced ocular damage. Ocular sun exposure has been related to cases of pterygia and was recently negatively correlated with myopia. Hence, CUVAF has excellent potential as an objective biomarker of sun exposure. However, much ...

Original Investigation 
Paul Hahn, MD, PhD; Mina M. Chung, MD; Harry W. Flynn Jr, MD; Suber S. Huang, MD, MBA; Judy E. Kim, MD; Tamer H. Mahmoud, MD, PhD; SriniVas R. Sadda, MD; Pravin U. Dugel, MD
Includes: Supplemental Content

Importance  Aflibercept-related sterile inflammation, an event that is poorly understood, has been the subject of ongoing postmarketing reports.

Objective  To analyze cases of aflibercept-related sterile inflammation reported to the American Society of Retina Specialists (ASRS) Therapeutic Surveillance Committee (TSC), an independent task force formed to monitor ...

Observation 
Benjamin P. Nicholson, MD; Sophie J. Bakri, MD
Numerous mechanisms of vision loss in silicone oil–filled eyes have been described in the literature. Silicone oil can cause keratopathy, glaucoma, optic neuropathy, and cataract.1,2 There have been reports of unexplained severe vision loss in eyes with good visual potential with long-term silicone oil tamponade.3 Imaging and histological studies of ...
Comment & Response 
Stephen Gbejule Odaibo, MD
To the Editor It was with great interest that I read the recent article by Mrejen et al.1 I commend the authors for their foresight in the use of multimodality imaging to further characterize acute zonal occult outer retinopathy (AZOOR). The study’s importance was stated as “the multimodal imaging in ...
Original Investigation  FREE
Carolina P. B. Gracitelli, MD; Ricardo Y. Abe, MD; Andrew J. Tatham, FRCOphth; Peter N. Rosen, MD; Linda M. Zangwill, PhD; Erwin R. Boer, PhD; Robert N. Weinreb, MD; Felipe A. Medeiros, MD, PhD
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Evaluation of structural optic nerve damage is a fundamental part of diagnosis and management of glaucoma. However, the relationship between structural measurements and disability associated with the disease is not well characterized. Quantification of this relationship may help validate structural measurements as markers directly relevant to ...

Original Investigation 
Wei-Chi Wu, MD, PhD; Reyin Lien, MD; Pei-Ju Liao, PhD; Nan-Kai Wang, MD, PhD; Yen-Po Chen, MD, PhD; An-Ning Chao, MD; Kuan-Jen Chen, MD; Tun-Lu Chen, MD; Yih-Shiou Hwang, MD, PhD; Chi-Chun Lai, MD

Importance  Intravitreous injections of bevacizumab (IVB) have been found to be effective for the treatment of retinopathy of prematurity (ROP). However, serum levels of vascular endothelial growth factor (VEGF) have been found to be suppressed for 2 weeks after IVB in patients with ROP. Changes in serum ...

Observation 
Madhu Uddaraju, MS; Jeena Mascarenhas, MS; Manoranjan Das, MS; N. Venkatesh Prajna, MD, FRCS
This case report describes a rare and intriguing case of bilateral concentric ring-shaped opacities not associated with any ocular or systemic conditions.
Comment & Response 
R. Rand Allingham, MD; M. Bruce Shields, MD
To the Editor Choi et al1 concluded that optic disc tilt, which they classified as a disc ovality (ratio between the longest and shortest disc diameters) greater than 1.30, appeared to be associated with bihemispheric retinal nerve fiber layer defects in patients with early glaucoma and that this association is ...
To the Editor The Invited Commentary by Naseri and McLeod1 on immediate sequential cataract surgery (ISCS) compared with delayed sequential cataract surgery (DSCS) based on my physician perspective cost-analysis model2 is an excellent analysis that discusses how premium intraocular lens (IOL) use may affect this model. It also reviews various ...
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