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 Showing 1-20 of 79 Articles
Brief Report 
Andrew M. J. Turnbull, BM; Michael Smith, FRCOphth; Mahesh Ramchandani, FRCS

Importance  Unlike other modes of long-distance travel, long-haul flights delay urgent, specialist medical treatment until the destination is reached or the plane is diverted. Angle-closure glaucoma (ACG) occurring during those flights results in considerable morbidity and may cause permanent visual loss. It is preventable in patients with ...

Ophthalmic Images 
Kapil G. Kapoor, MD; Andrew J. Barkmeier, MD
Graphic Jump LocationThis patient noted a yellow spot in her vision and optical coherence tomography revealed foveal shadowing from a pseudo-operculum. This classic case of xanthic scotoma is distinguished from a true operculum by the normal foveal contour.
Topics: scotoma; eye
Comment & Response 
Henri Sueke, FRCOphth; Arvind Chandna, FRCOphth
To the Editor We read with interest the article on 4.5-year visual acuity outcomes for the Infant Aphakia Treatment Study (IATS).1 This is clearly a well-thought-out and meticulously devised study.
Monica M. Michelotti, MD; Nieraj Jain, MD; Mark W. Johnson, MD
Diabetic macular edema can be resistant to anti–vascular endothelial growth factor (VEGF) therapy, and long-term consequences of VEGF suppression are not well understood.1 Previous studies in central retinal vein occlusion have associated exudative retinal detachment with increased production of VEGF and interleukin 6,2 and localized central serous retinal detachment has ...
Comment & Response 
Scott R. Lambert, MD; Michael J. Lynn, MS; E. Eugenie Hartmann, PhD; for the Infant Aphakia Treatment Study Group
In Reply We appreciate the interest of Sueke and Chandna in the outcomes of the IATS.
Original Investigation 
Nienke Visser, MD; Henny J. M. Beckers, MD, PhD; Noel J. C. Bauer, MD, PHD; Sacha T. J. M. Gast, MD; Bart L. M. Zijlmans, MD; Tos T. J. M. Berenschot, PhD; Carroll A. Webers, MD, PhD; Rudy M. M. A. Nuijts, MD, PhD
Includes: Supplemental Content

Importance  Spectacle independence is becoming increasingly important in cataract surgery. Not correcting corneal astigmatism at the time of cataract surgery will fail to achieve spectacle independency in 20% to 30% of patients.

Objective  To compare bilateral aspherical toric with bilateral aspherical control intraocular lens (IOL) implantation ...

Original Investigation 
Harsha L. Rao, MD, DNB; Ravi K. Yadav, B Opt; Viquar U. Begum, B Opt; Uday K. Addepalli, B Opt; Nikhil S. Choudhari, DNB; Sirisha Senthil, MD, FRCS; Chandra S. Garudadri, MD, FRCS

Importance  Standard automated perimetry is the current criterion standard for assessment of visual field (VF) loss in glaucoma. The 3 commonly used reliability indices to judge the quality of standard automated perimetry results are fixation losses (FLs) and false-positive (FP) and false-negative (FN) response rates. However, the ...

Adam R. Glassman, MS; Michele Melia, ScM
This Viewpoint discusses randomizing one eye vs both eyes in ophthalmic clinical trials.
Topics: eye

Importance  A cost analysis was performed to evaluate the effect on physicians in the United States of a transition from delayed sequential cataract surgery to immediate sequential cataract surgery. Financial and efficiency impacts of this change were evaluated to determine whether efficiency gains could offset potential reduced ...

Ophthalmic Images 
Roger A. Goldberg, MD, MBA; Nadia K. Waheed, MD
Graphic Jump LocationSaggital (A) and axial (B) computed tomographic images demonstrate anesthetic injected into the optic nerve during retrobulbar block. Images were obtained while the patient was intubated for apnea that developed approximately 5 minutes after retrobulbar injection. The patient was successfully extubated 6 hours later. One day later, the ...
Invited Commentary 
Ayman Naseri, MD; Stephen McLeod, MD
In this issue of JAMA Ophthalmology, Neel1 revisits the issue of the relative cost of immediate sequential cataract surgery (ISCS), ie, performed on the same day, compared with delayed sequential cataract surgery (DSCS). Unlike many previous analyses that have focused on payer and societal costs (and is the subject of ...
Comment & Response 
Sertan Goktas, MD; Yasar Sakarya, MD; Rabia Sakarya, MD
To the Editor We read the article titled “Efficacy and Safety of Antifungal Additives in Optisol-GS Corneal Storage Medium” by Layer et al1 with interest. In their article, the authors investigated the efficacy and safety of voriconazole and amphotericin B in reducing Candida species contamination of Optisol-GS under normal storage ...
Gargi Khare Vora, MD; Brian Marr, MD; Thomas J. Cummings, MD; Prithvi Mruthyunjaya, MD
A conjunctival mass in a patient with human immunodeficiency virus (HIV) can have a long differential diagnosis, ranging from opportunistic infections to malignant neoplasms. Given that patients in this population may have atypical presentations, the benefit of invasive biopsy often outweighs surgical risk and can help guide treatment. We report ...
Comment & Response 
Noelle L. Pruzan, MD; Jeremy D. Keenan, MD, MPH; Bennie H. Jeng, MD, MS
In Reply There is no gold standard or widely accepted staining protocol for assessing endothelial cell death in human corneas after storage. We followed the vital dye staining protocol proposed by Park et al,1 who validated the ability of trypan blue to detect endothelial damage by comparing corneas exposed to ...
Original Investigation 
William G. Christen, ScD; Robert J. Glynn, ScD; J. Michael Gaziano, MD; Amy K. Darke, MS; John J. Crowley, PhD; Phyllis J. Goodman, MS; Scott M. Lippman, MD; Thomas E. Lad, MD; James D. Bearden, MD; Gary E. Goodman, MD; Lori M. Minasian, MD; Ian M. Thompson Jr, MD; Charles D. Blanke, MD; Eric A. Klein, MD
Includes: Supplemental Content

Importance  Observational studies suggest a role for dietary nutrients such as vitamin E and selenium in cataract prevention. However, the results of randomized clinical trials of vitamin E supplements and cataract have been disappointing and are not yet available for selenium.

Objective  To test whether long-term ...

Original Investigation 
Lindsay N. Boyers, BA; Chante Karimkhani, BA; John Hilton, MSc, MPhil; William Richheimer, MD; Robert P. Dellavalle, MD, PhD, MSPH
Includes: Supplemental Content

Importance  Eye and vision disease burden should help guide ophthalmologic research prioritization. The Global Burden of Disease (GBD) Study 2010 compiled data from 1990 to 2010 on 291 diseases and injuries, 1160 disease and injury sequelae, and 67 risk factors in 187 countries. The Cochrane Database of ...

Original Investigation 
Nicolas A. Yannuzzi, MD; Michael A. Klufas, MD; Lucy Quach, BS; Lauren M. Beatty, BA; Stephen M. Kaminsky, PhD; Ronald G. Crystal, MD; Donald J. D’Amico, MD; Szilárd Kiss, MD

Importance  Bevacizumab acquired from compounding pharmacies for intravitreal injection may cause infectious and noninfectious inflammation. In addition to safety issues, the drug itself may have variable efficacy associated with product aliquoting, handling, and distribution.

Objective  To conduct surveillance cultures, evaluate endotoxin levels, and assess protein concentrations ...

Brief Report 
Fook Chang Lam, MRCP, FRCOphth; Lamis Baydoun, MD; Martin Dirisamer, MD; Jessica Lie, PhD; Isabel Dapena, MD, PhD; Gerrit R. J. Melles, MD, PhD

Importance  This study evaluates the technical feasibility and clinical outcomes of a Descemet membrane endothelial keratoplasty (DMEK) technique that could increase the availability of donor tissue for DMEK.

Objective  To evaluate the clinical outcome of using a semicircular, large-diameter Descemet membrane graft in DMEK (hemi-DMEK), potentially ...

Ophthalmic Images 
Vivian Lee, MD; Benjamin J. Kim, MD
Graphic Jump LocationA woman in her early 70s with a retinal detachment for 3 months underwent repair, when a subretinal, soft mass was identified. Histopathologic analysis demonstrated birefringent crystals consistent with calcium oxalate, an uncommon finding with chronic detachments (hematoxylin-eosin, original magnification ×10 [A]; polarized light, original magnification ×10 [B]). ...
Topics: eye
Comment & Response 
Richard C. Allen, MD, PhD; Ryan J. Wise, MD
To the Editor We read with special interest the article titled “Botulinum Toxin Type A Injection for Lateral Canthal Rhytids: Effect on Tear Film Stability and Tear Production” by Ho et al1 and offer additional support for the mechanism by which botulinum toxin injection may alter the functioning of the ...

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