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Original Investigation 
Joseph Moisseiev, MD; Iris Moroz, MD; Gabriel Katz, MD

Importance  Assessing the effect of ocriplasmin availability on the management of full-thickness macular holes (MHs) is important for vitreoretinal surgeons and their patients. Such an assessment can indicate whether the use of ocriplasmin will bring a paradigm shift in treating MHs or will be just an additional ...

Original Investigation 
Renbing Jia, MD, PhD; Shiqiong Xu, MD; Xiaolin Huang, MD; Xin Song, MD; Hui Pan, MD; Leilei Zhang, MD; Fanglin He, MD; Ming Lin, MD; Shengfang Ge, PhD; Xianqun Fan, MD, PhD
Includes: Supplemental Content

Importance  Low-flow orbital or periorbital venous malformation (OVM) is the most common periorbital vascular lesion that may produce an appearance defect, visual dysfunction, internal hemorrhage, and thrombosis. Intralesional injection of pingyangmycin as a minimally invasive, gentle intervention may have better outcomes in treating low-flow OVMs compared with ...

Original Investigation 
Carol L. Shields, MD; Sruthi Arepalli, BA; Erin B. Lally, MD; Sara E. Lally, MD; Jerry A. Shields, MD

Importance  The management of symptomatic iris stromal cyst is challenging using methods of aspiration with or without adjunctive cryotherapy, intracameral cautery, or photocoagulation. Failed cases often require surgical resection, with risks for epithelial downgrowth, glaucoma, blindness, and loss of the eye.

Objective  To study the safety ...

Original Investigation 
Hossein Nazari, MD; Petros C. Karakousis, MD; Narsing A. Rao, MD

Importance  Mycobacterium tuberculosis is an important cause of posterior uveitis in tuberculosis-endemic regions. Clinical and histopathologic evidence suggests that retinal pigment epithelium (RPE) can harbor M tuberculosis. However, the mechanism of M tuberculosis phagocytosis and its growth in RPE is not clear.

Objective  To investigate ...

Original Investigation 
Ankoor S. Shah, MD, PhD; Sanjay P. Prabhu, MBBS, FRCR; Mohammad Ali A. Sadiq, MD; Iason S. Mantagos, MD; David G. Hunter, MD, PhD; Linda R. Dagi, MD
Includes: Supplemental Content

Importance  Third nerve palsy causes disfiguring, incomitant strabismus with limited options for correction.

Objective  To evaluate the oculomotor outcomes, anatomical changes, and complications associated with adjustable nasal transposition of the split lateral rectus (LR) muscle, a novel technique for managing strabismus associated with third nerve palsy....

Ophthalmic Images 
Jia-Kang Wang, MD; Ting-Yu Shih, MD
Graphic Jump LocationTriamcinolone acetonide (40 mg in 1 mL) was accidentally injected into the optic nerve with a 25-gauge 1-in needle in a 55-year-old woman. Fundus photography of the optic disc showed overlying protruding triamcinolone acetonide suspension (A) and subsequent atrophy 6 months later (B).
Ophthalmic Images 
Kailun Jiang, MD; Seymour Brownstein, MD; Kay Lam, MD; David Chow, MD; W. Bruce Jackson, MD
Graphic Jump LocationA, An 87-year-old woman with bilateral posterior polymorphous amyloid degeneration showing deep corneal stromal punctate/droplike lesions (arrowheads) on right eye retroillumination. B, Histopathological examination disclosed numerous amorphous, deep corneal stromal deposits (hematoxylin-eosin, original magnification ×40). C and D, Congophilic deposits with apple-green birefringence (Congo red, original magnification ×100). ...
Original Investigation 
Evelyn C. O’Neill, MB, BCh, BAO, MD, MRCOphth; Lulu U. Gurria, MD; Surinder S. Pandav, MBBS, MS; Yu Xiang G. Kong, MBBS, PhD; Jessica F. Brennan, BOrth&OphthalSc; Jing Xie, MD, PhD; Michael A. Coote, MBBS, FRANZCO; Jonathan G. Crowston, PhD, FRANZCO

Importance  Glaucoma is a significant health problem for which diagnosis remains suboptimal. Optic disc evaluation, which is fundamental to the diagnosis, is a difficult skill to acquire.

Objectives  To determine the optic disc characteristics that most influence decision making in the assessment of glaucoma likelihood and ...

Original Investigation 
Jae H. Kang, ScD; Stephanie J. Loomis, MPH; Janey L. Wiggs, MD, PhD; Walter C. Willett, MD, DrPH; Louis R. Pasquale, MD

Importance  Effective strategies for primary prevention are lacking for exfoliation glaucoma (EG), which is the most common type of secondary glaucoma.

Objective  To examine the association between B vitamin intake and EG or suspected EG (EG/SEG) risk.

Design, Setting, and Participants  National prospective cohort study ...

Original Investigation 
Robert Ritch, MD; Ben Darbro, MD, PhD; Geeta Menon, MD; Cheryl L. Khanna, MD; Frances Solivan-Timpe, BS; Ben R. Roos, BS; Mansoor Sarfarzi, PhD; Kazuhide Kawase, MD; Tetsuya Yamamoto, MD; Alan L. Robin, MD; Andrew J. Lotery, MD; John H. Fingert, MD, PhD

Importance  Normal-tension glaucoma (NTG) is a common cause of vision loss.

Objective  To investigate the role of TANK binding kinase 1 (TBK1) gene duplications in NTG to gain insights into the causes of glaucoma that occurs at low intraocular pressure (IOP).

Design, Setting, and ...

Brief Report 
Zhijia Hou, MD; Bobby S. Korn, MD; Jingwen Ding, MD; Dongmei Li, MD

Importance  Extensive epibulbar choristomas associated with microphthalmia have rarely been reported. We report 2 cases and describe our experience in the diagnosis and management of this challenging entity.

Observations  The clinical features, surgical and histopathologic findings, and aesthetic results of surgical treatment were recorded.

Conclusions and ...

Brief Report 
Amir A. Azari, MD; Mozhgan R. Kanavi, MD; Mark Lucarelli, MD; Vivian Lee, MD; Ashley M. Lundin, MD; Heather D. Potter, MD; Daniel M. Albert, MD

Importance  To report the clinical and histopathologic findings of ocular adnexal angiolymphoid hyperplasia with eosinophilia, an unusual but often misdiagnosed benign disorder.

Observations  The ophthalmologic findings of angiolymphoid hyperplasia with eosinophilia with ocular adnexal involvement are variable and include eyelid swelling, ptosis, proptosis, and loss of ...

Ophthalmic Images 
Jose M. Caminal, MD, PhD; Daniel E. Maidana, MD; Pablo Carnota, MD; Estefanía Cobos-Martin, MD; Luis Arias, MD, PhD
Graphic Jump LocationA, At presentation, there is a 3.5-mm–diameter sporadic hemangioblastoma, feeding arteriole, draining vein, hemorrhages, and exudation. B, Fluorescein angiogram at presentation. C, Three months after photodynamic therapy (50 J/cm2), there is clearance of hemorrhages. D, Follow-up at 37 months shows clearance of exudation and tumor size reduction.
Original Investigation 
Zia Chaudhuri, MS, FRCS(Glasg); Joseph L. Demer, MD, PhD

Importance  Extraocular muscle strengthening is a common treatment for strabismus. Plication is an alternative procedure for strengthening muscles with less tissue trauma than resection.

Objective  To compare the surgical dose effect of plication with that of resection.

Design, Setting, and Participants  Retrospective comparison of surgical ...

Original Investigation 
David S. Sanders, BS; Sarah Read-Brown, BA; Daniel C. Tu, MD; William E. Lambert, PhD; Dongseok Choi, PhD; Bella M. Almario, RN, MPH; Thomas R. Yackel, MD, MPH, MS; Anna S. Brown, RN; Michael F. Chiang, MD
Includes: Supplemental Content

Importance  Although electronic health record (EHR) systems have potential benefits, such as improved safety and quality of care, most ophthalmology practices in the United States have not adopted these systems. Concerns persist regarding potential negative impacts on clinical workflow. In particular, the impact of EHR operating room ...

Original Investigation 
Amit K. Reddy, BS; Meredith S. Baker, MD; Rachel K. Sobel, MD; David A. Whelan, MHA; Keith D. Carter, MD; Richard C. Allen, MD, PhD

Importance  Suicides and attempted suicides are major public health issues in the United States and around the world. Self-inflicted gunshot wounds (SIGSWs) are a common method of attempting suicide, the head being the most commonly injured body region; however, the literature lacks an overview of the orbital ...

Original Investigation 
Kyu Hyung Park, MD, PhD; Yong-Kyu Kim, MD; Se Joon Woo, MD, PhD; Se Woong Kang, MD, PhD; Won Ki Lee, MD, PhD; Kyung Seek Choi, MD, PhD; Hyung Woo Kwak, MD, PhD; Ill Han Yoon, MD, PhD; Kuhl Huh, MD, PhD; Jong Woo Kim, MD, PhD; for the Korean Retina Society
Includes: Supplemental Content

Importance  Iatrogenic occlusion of the ophthalmic artery and its branches is a rare but devastating complication of cosmetic facial filler injections.

Objective  To investigate clinical and angiographic features of iatrogenic occlusion of the ophthalmic artery and its branches caused by cosmetic facial filler injections.

Design, Setting, ...

Original Investigation 
Paul Yang, MD, PhD; Keith V. Michaels, BS; Robert J. Courtney, MD; Yuquan Wen, PhD; Daniel A. Greninger, MD; Leah Reznick, MD; Daniel J. Karr, MD; Lorri B. Wilson, MD; Richard G. Weleber, MD; Mark E. Pennesi, MD, PhD

Importance  While older children and adults with achromatopsia have been studied, less is known of young children with achromatopsia.

Objectives  To characterize the macular and foveal architecture of patients with achromatopsia during early childhood with handheld spectral-domain optical coherence tomographic imaging and to make phenotype-genotype correlations....

Viewpoint 
Emily Y. Chew, MD
The recent editorial “Enough is Enough: Stop Wasting Money on Vitamin and Mineral Supplements” in the Annals of Internal Medicine denounces the use of multivitamin and mineral supplementation in the general population for the prevention or treatment of chronic diseases.1 The authors are likely correct and appropriate in their conclusions. ...
Original Investigation 
Eric B. Suhler, MD, MPH; Lyndell L. Lim, MD; Robert M. Beardsley, MD; Tracy R. Giles, BS; Sirichai Pasadhika, MD; Shelly T. Lee, MD; Alexandre de Saint Sardos, MD; Nicholas J. Butler, MD; Justine R. Smith, MBBS, PhD; James T. Rosenbaum, MD

Importance  Orbital inflammation is a potentially blinding and disfiguring disease process that is often treated with systemic corticosteroids and immunosuppression; better treatments are needed.

Objective  To determine whether rituximab, a monoclonal antibody against the B-lymphocyte antigen CD20, is effective in the treatment of refractory orbital inflammation....

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