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 Showing 1-20 of 64 Articles
Original Investigation  FREE
Carolyn Drews-Botsch, MD; Marianne Celano, PhD; George Cotsonis, MA; E. Eugenie Hartmann, PhD; Scott R. Lambert, MD; for the Infant Aphakia Treatment Study Group
Includes: Supplemental Content

Importance  Patching has been a mainstay in treating unilateral congenital cataract. However, its efficacy has not been rigorously assessed.

Objective  To examine the association between patching and visual acuity in a cohort of children treated for unilateral congenital cataract.

Design, Setting, and Participants  This study ...

Original Investigation 
Bo Ram Seol, MD; Ho-Kyung Choung, MD; Namju Kim, MD; Min Joung Lee, MD; Sang In Khwarg, MD

Importance  Epiblepharon is known to be bilateral and symmetric. However, asymmetric epiblepharon is frequently observed in patients with head tilt and, to date, this condition has not been investigated.

Objectives  To evaluate the clinical features of epiblepharon in patients with head tilt and to analyze the ...

Original Investigation  FREE
Camila V. Ventura, MD; Mauricio Maia, MD, PhD; Simone B. Travassos, MD; Thayze T. Martins, MD; Felipe Patriota, MD; Marcos Eugênio Nunes, MD; Cristiana Agra, MD; Virginia L. Torres, MD, PhD; Vanessa van der Linden, MD; Regina C. Ramos, MD; Maria Ângela W. Rocha, MD; Paula S. Silva, MD; Liana O. Ventura, MD, PhD; Rubens Belfort Jr, MD, PhD
Includes: Supplemental Content

Importance  The Zika virus (ZIKV) might cause microcephaly and ophthalmoscopic findings in infants of mothers infected during pregnancy.

Objective  To assess and identify possible risk factors for ophthalmoscopic findings in infants born with microcephaly and a presumed clinical diagnosis of ZIKV intrauterine infection.

Design, Setting, and ...

Brief Report 
Ling Zhi Heng, MBBS, PhD; Ranjit Sandhu, MRCOphth, MD, FRCOphth; D. R. J. Snead, MBBS, FRCPath; Arabella Poulson, MBBS, FRCOphth; Martin Snead, MD, FRCS, FRCOphth

Importance  In-the-bag intraocular lens dislocation is an uncommon but serious complication of cataract surgery in patients with previous repair of retinal detachment. The causative mechanism is currently unknown. We report histologic findings from a retrospective case series from 1993 to 2010 and suggest a possible mechanism to ...

Special Communication 
Marco A. Zarbin, MD, PhD
Includes: Supplemental Content

The relevance of clinical trial results to clinical practice hinges on 2 critical questions: Will the results be replicated in one’s practice, and Are the results clinically important? The answers to the following 5 questions may help one determine how relevant a study result is to clinical practice. ...

JAMA Ophthalmology Clinical Challenge 
Andrew W. Francis, MD; Pete Setabutr, MD; Vinay Aakalu, MD

A girl in her midteens was evaluated for proptosis. What would you do next?

Ehsan Rahimy, MD; Michael W. Gaynon, MD; Yannis M. Paulus, MD; Janet L. Alexander, MD; Sam E. Mansour, MD

This case report describes a 63-year-old man with a history of hypertension, hyperlipidemia, and multiple strokes who presented with vision loss in the right eye, and after 1.5 years of persistent cystoid macular edema, he began a trial of niacin therapy.

Shilpa J. Desai, MD; Jeffrey S. Heier, MD

This case report describes a man in his 50s who months after retina surgery reported severe pain in his left eye whenever he was 1200 m above sea level.

Comment & Response 
Dustin D. French, PhD; Curtis E. Margo, MD, MPH; Paul B. Greenberg, MD

To the Editor In their article on geographic variation in the rate and timing of cataract surgery in US communities, Kauh et al1 analyzed beneficiary records from a nationwide managed-care network provided by OptumInsight, a subsidiary of UnitedHealth Corp. The authors found considerable variation in age at ...

Comment & Response 
Joshua D. Stein, MD, MS; Paul P. Lee, MD, JD

In Reply We agree that market forces and contractual arrangements can contribute to some of the geographic variation noted in our study. All of the data to which we had access for our study came from patients who were receiving their care from the same managed-care network. We ...

Original Investigation 
Sang Jun Park, MD, MSc; Soyeon Ahn, PhD; Kyu Hyung Park, MD, PhD
Includes: Supplemental Content

Importance  Visual impairment (VI) is an emerging public health concern, especially considering the aging population. However, unlike other major chronic diseases, VI is often overlooked by investigators assessing the burden of diseases.

Objectives  To provide a description of preference weights for VI and chronic diseases from ...

Original Investigation 
Rohit Varma, MD, MPH; Jeniffer S. Kim, MPH; Bruce S. Burkemper, PhD, MPH; Ge Wen, MSc; Mina Torres, MS; Chunyi Hsu, MPH; Farzana Choudhury, PhD; Stanley P. Azen, PhD; Roberta McKean-Cowdin, PhD; for the Chinese American Eye Study Group

Importance  Visual impairment (VI) and blindness continue to be major public health problems worldwide. Despite previously published studies on VI in Chinese and other racial/ethnic populations, there are no data specific to Chinese American adults.

Objectives  To determine the age- and sex-specific prevalence and causes of ...

Original Investigation 
Phillippa M. Cumberland, MSc; Antonietta Chianca, PhD; Jugnoo S. Rahi, PhD, FRCOphth; for the UK Biobank Eye and Vision Consortium
Includes: Supplemental Content

Importance  Large-scale generic studies offer detailed information on potential risk factors for refractive error across the life course, but ophthalmic examination in such cases to determine the refractive error phenotype is challenging and costly. Thus, refractive status is commonly assigned using questionnaires. In a population survey, often ...

Original Investigation 
Rohit Varma, MD, MPH; Thasarat S. Vajaranant, MD; Bruce Burkemper, PhD, MPH; Shuang Wu, MS; Mina Torres, MS; Chunyi Hsu, MPH; Farzana Choudhury, MBBS, MPH, MS, PhD; Roberta McKean-Cowdin, PhD
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  The number of individuals with visual impairment (VI) and blindness is increasing in the United States and around the globe as a result of shifting demographics and aging populations. Tracking the number and characteristics of individuals with VI and blindness is especially important given the negative ...

JAMA Ophthalmology Clinical Challenge 
Paras Vakharia, PharmD; Yoshihiro Yonekawa, MD; Sandeep Randhawa, MD

A woman in her 80s who had been treated for non–small cell lung cancer 2 years prior was seen with blurred vision in the right eye for 1 week and a lesion that stained on fluorescein angiography. What would you do next?

James T. Rosenbaum, MD

This Viewpoint chronicles the story of a former uveitis fellow whose metastasized cancer has left her blind and reflects on the 2-way nature of mentoring.

Original Investigation 
Sarah Hull, MA, FRCOphth, PhD; Gavin Arno, PhD; Cristy A. Ku, PhD; Zhongqi Ge, PhD; Naushin Waseem, PhD; Aman Chandra, FRCOphth, PhD; Andrew R. Webster, MD(Res), FRCOphth; Anthony G. Robson, MSc, PhD; Michel Michaelides, MD(Res), FRCOphth; Richard G. Weleber, MD; Indran Davagnanam, MD(Res), FRCR; Rui Chen, PhD; Graham E. Holder, MSc, PhD; Mark E. Pennesi, MD, PhD; Anthony T. Moore, MA, FRCOphth
Includes: Supplemental Content

Importance  Knobloch syndrome is a rare, recessively inherited disorder classically characterized by high myopia, retinal detachment, and occipital encephalocele, but it is now known to have an increasingly variable phenotype. There is a lack of reported electrophysiologic data, and some key clinical features have yet to be ...

Original Investigation 
Keisuke Kawata, MS; Leah H. Rubin, PhD, MPH; Jong Hyun Lee; Thomas Sim; Masahiro Takahagi, MEd; Victor Szwanki, MS; Al Bellamy, MS; Kurosh Darvish, PhD; Soroush Assari, BS, MS; Jeffrey D. Henderer, MD; Ryan Tierney, PhD; Dianne Langford, PhD
Includes: Supplemental Content

Importance  An increased understanding of the relationship between subconcussive head impacts and near point of convergence (NPC) ocular-motor function may be useful in delineating traumatic brain injury.

Objective  To investigate whether repetitive subconcussive head impacts during preseason football practice cause changes in NPC.

Design, Setting, and ...

Invited Commentary: Subconcussive Head Trauma and Near Point of Convergence; Andrew G. Lee, MD; Steven L. Galetta, MD
Original Investigation 
Brian S. Boxer Wachler, MD

Importance  Ultraviolet A (UV-A) light is associated with the risks of cataract and skin cancer.

Objective  To assess the level of UV-A light protection in the front windshields and side windows of automobiles.

Design  In this cross-sectional study, 29 automobiles from 15 automobile manufacturers were ...

Invited Commentary 
Jayne S. Weiss, MD

UV radiation from the sun is associated with 90% of skin cancers and is linked to cataract formation. The adverse effects of UV radiation while driving have been previously reported. Previous publications have documented increased prevalence of left-sided cortical cataracts1 and skin cancers2 because of asymmetrical ...

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