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 Showing 1-20 of 74 Articles
Original Investigation 
Vatinee Y. Bunya, MD; Nicole M. Fuerst, MD; Maxwell Pistilli, MEd, MS; Bridgette E. McCabe, BS; Rebecca Salvo, BA; Ilaria Macchi, MD; Gui-Shuang Ying, PhD; Mina Massaro-Giordano, MD
Includes: Supplemental Content

Importance  Knowledge about the variability of measurements using the TearLab Osmolarity System is necessary when evaluating the clinical utility of readings.

Objective  To examine the variability of tear osmolarity measured by the TearLab Osmolarity System in patients with Sjögren syndrome (SS), patients with blepharitis, and control ...

Original Investigation 
Ebenezer Daniel, MBBS, MS, MPH, PhD; Graham E. Quinn, MD, MSCE; P. Lloyd Hildebrand, MD; Anna Ells, MD, FRCS(C); G. Baker Hubbard III, MD; Antonio Capone Jr, MD; E. Revell Martin, BA; Candace P. Ostroff, BA; Eli Smith, BA; Maxwell Pistilli, MS; Gui-Shuang Ying, PhD; for the e-ROP Cooperative Group
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Measurable competence derived from comprehensive and advanced training in grading digital images is critical in studies using a reading center to evaluate retinal fundus images from infants at risk for retinopathy of prematurity (ROP). Details of certification for nonphysician trained readers (TRs) have not yet been ...

Original Investigation 
Julia S. Steinberg, MD; Fred W. Fitzke, PhD; Rolf Fimmers, PhD; Monika Fleckenstein, MD; Frank G. Holz, MD; Steffen Schmitz-Valckenberg, MD, FEBO
Includes: Supplemental Content

Importance  Clinical observations suggest that patients with age-related macular degeneration (AMD) have vision problems, particularly in dim light conditions. Previous studies on structural-functional analysis in patients with AMD with reticular drusen (RDR) have focused on photopic sensitivity testing but have not specifically assessed scotopic function.

Objective  ...

New Instrument 
Ehsan Rahimy, MD; Sunir J. Garg, MD
Includes: Supplemental Content
This Clinical Review describes the experience of using Google Glass to record scleral buckling surgery and discusses its potential use in medical education.
Observation 
Alla Kelly, MD; Stephen C. Kaufman, MD, PhD
Anterior chamber cosmetic iris implants permanently alter the apparent iris color. Previous reports of these implants highlight adverse outcomes with severe ocular morbidity, including glaucoma, corneal endothelial decompensation, iris damage, and uveitis, which may result in vision loss.1- 3 These reports concern the NewColorIris implant (Kahn Medical Devices). We report ...
To the Editor We thank Dr Messori1 for the interest in our 2 articles from the Comparison of Age-Related Macular Degeneration Treatments Trials.2,3 Dr Messori believes that results in the 2 articles for comparison of visual acuity between eyes treated with bevacizumab and eyes treated with ranibizumab are contradictory.1 Dr ...
Original Investigation 
Bethany Stavert, BSc; Myra B. McGuinness, MSc; C. Alex Harper, MBBS; Robyn H. Guymer, PhD; Robert P. Finger, PhD
Includes: Supplemental Content

Importance  Topical phenylephrine hydrochloride is routinely administered with few safety precautions, but evidence regarding its systemic safety to date is controversial. As even short-term variations in 24-hour blood pressure (BP) and heart rate (HR) can adversely affect cardiovascular health, better evidence on phenylephrine’s effects on HR and ...

Original Investigation 
Paul Yang, MD, PhD; Pei-Wen Chiang, PhD; Richard G. Weleber, MD; Mark E. Pennesi, MD, PhD
Includes: Supplemental Content

Importance  The patients evaluated in this study, to our knowledge, represent the first complete clinical description of a family with an autosomal dominant inheritance pattern of retinal dystrophy associated with a novel mutation in RAX2.

Objectives  To clinically evaluate 4 patients and 5 unaffected family ...

Special Communication 
Edwin M. Stone, MD, PhD

Age-related macular degeneration is a very common condition that is caused by a complex interplay of genetic and environmental factors. It is likely that, in the future, genetic testing will allow physicians to achieve better clinical outcomes by administering specific treatments to patients based on their genotypes. However, ...

Observation 
Ebba Nissen, MD; John Armitage, PhD; Sophie Thornton, BSc; Sarah E. Coupland, MBBS, PhD, FRCPath
With the exception of melanocytomas, ciliary body nevi are rare. Previous case series have reported episcleral nodular extension of ciliary body nevi leading to their diagnosis1 or alternatively ciliary body nevi with involvement of the iris root, resulting in their detection using slitlamp biomicroscopy.2 Herein, we report a pigmented limbal ...
Comment & Response 
Andrés J. M. Ferreri, MD
To the Editor I read with great interest the article by Munch-Petersen et al1 on a retrospective series of 100 patients with ocular adnexal diffuse large B-cell lymphoma (OA-DLBCL). The authors should be commended for their effort to investigate the role of staging systems and to establish survival figures in ...
Comment & Response 
Helga D. Munch-Petersen, MD; Peter K. Rasmussen, MD, PhD; Steffen Heegaard, MD, DMSc
In Reply We read with interest Ferreri’s comments on our multicenter work on OA-DLBCL.1 We are pleased to have the opportunity to contribute with further information regarding this uncommon subcategory of extranodal non-Hodgkin lymphoma.
Original Investigation 
Martin Gliem, MD; Doris Hendig, PhD; Robert P. Finger, MD, PhD; Frank G. Holz, MD; Peter Charbel Issa, MD, DPhil
Includes: Supplemental Content

Importance  Reticular pseudodrusen (RPD) are frequently associated with age-related macular degeneration and considered to be an independent risk factor for disease progression, but the pathophysiologic mechanisms are only incompletely understood. Therefore, it may be helpful to identify the associations of RPD with other diseases that have defined ...

Original Investigation 
Vinit B. Mahajan, MD, PhD; Eric K. Chin, MD; Ryan M. Tarantola, MD; David R. P. Almeida, MD, MBA, PhD; Riz Somani, MD; H. Culver Boldt, MD; James C. Folk, MD; Karen M. Gehrs, MD; Stephen R. Russell, MD

Importance  Internal limiting membrane (ILM) abrasion is an alternative surgical technique for successful full-thickness macular hole (MH) repair.

Objective  To study the effects of ILM abrasion as an alternative method of MH repair.

Design, Setting, and Participants  Retrospective consecutive case series from January 2006 to ...

Original Investigation 
Jennifer Rose-Nussbaumer, MD; N. Venkatesh Prajna, MD; K. Tiruvengada Krishnan, MD; Jeena Mascarenhas, MD; Revathi Rajaraman, MD; Muthiah Srinivasan, MD; Anita Raghavan, MD; Catherine E. Oldenburg, MPH; Kieran S. O’Brien, MPH; Kathryn J. Ray, MA; Stephen D. McLeod, MD; Travis C. Porco, PhD, MPH; Thomas M. Lietman, MD; Nisha R. Acharya, MD, MS; Jeremy D. Keenan, MD, MPH; for the Mycotic Ulcer Treatment Trial I Group
Includes: Supplemental Content

Importance  Given the limitations in health care resources, quality-of-life measures for interventions have gained importance.

Objective  To determine whether vision-related quality-of-life outcomes were different between the natamycin and voriconazole treatment arms in the Mycotic Ulcer Treatment Trial I, as measured by an Indian Vision Function Questionnaire....

Observation 
Katrina Mears, MD; Benjamin Bakall, MD, PhD; Lisa A. Harney, BA; Jessica A. Penticoff, BA; Edwin M. Stone, MD, PhD
The syndrome now known as microcephaly associated with congenital lymphedema and chorioretinopathy (MLCR) was first described in 1980 by Alzial et al.1 Microcephaly with chorioretinal dysplasia has been reported to be inherited in an autosomal dominant or autosomal recessive manner and has a variety of associations, including lymphedema and mental ...
Comment & Response 
Janet L. Davis, MD; Chi-Chao Chan, MD; Debra A. Goldstein, MD, FRCSC
To the Editor We read with interest the article by Franco-Cardenas et al1 concerning authorship of scientific literature in ophthalmology by women. The article concentrated on 3 top journals with high impact factors. Readers may also be interested in our project, which we believe may be relevant not only to ...
Comment & Response 
Irena Tsui, MD; Jamie B. Rosenberg, MD; Valentina Franco-Cardenas, MD
In Reply We thank Davis and colleagues for their interest in our article about publication trends in ophthalmology during the past decade and for directing us to read their recently published work. While we wholeheartedly agree that these are important topics, we view the 2 issues as being distinct and ...
Viewpoint 
Teresa C. Chen, MD; Oliver D. Schein, MD, MPH, MBA; Joan W. Miller, MD
This Viewpoint discusses ways in which to address sentinel events, serious reportable events, and root cause analysis.

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