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 Showing 1-20 of 71 Articles

Importance  A cost analysis was performed to evaluate the effect on physicians in the United States of a transition from delayed sequential cataract surgery to immediate sequential cataract surgery. Financial and efficiency impacts of this change were evaluated to determine whether efficiency gains could offset potential reduced ...

Ophthalmic Images 
Roger A. Goldberg, MD, MBA; Nadia K. Waheed, MD
Graphic Jump LocationSaggital (A) and axial (B) computed tomographic images demonstrate anesthetic injected into the optic nerve during retrobulbar block. Images were obtained while the patient was intubated for apnea that developed approximately 5 minutes after retrobulbar injection. The patient was successfully extubated 6 hours later. One day later, the ...
Invited Commentary 
Ayman Naseri, MD; Stephen McLeod, MD
In this issue of JAMA Ophthalmology, Neel1 revisits the issue of the relative cost of immediate sequential cataract surgery (ISCS), ie, performed on the same day, compared with delayed sequential cataract surgery (DSCS). Unlike many previous analyses that have focused on payer and societal costs (and is the subject of ...
Comment & Response 
Sertan Goktas, MD; Yasar Sakarya, MD; Rabia Sakarya, MD
To the Editor We read the article titled “Efficacy and Safety of Antifungal Additives in Optisol-GS Corneal Storage Medium” by Layer et al1 with interest. In their article, the authors investigated the efficacy and safety of voriconazole and amphotericin B in reducing Candida species contamination of Optisol-GS under normal storage ...
Observation 
Gargi Khare Vora, MD; Brian Marr, MD; Thomas J. Cummings, MD; Prithvi Mruthyunjaya, MD
A conjunctival mass in a patient with human immunodeficiency virus (HIV) can have a long differential diagnosis, ranging from opportunistic infections to malignant neoplasms. Given that patients in this population may have atypical presentations, the benefit of invasive biopsy often outweighs surgical risk and can help guide treatment. We report ...
Comment & Response 
Noelle L. Pruzan, MD; Jeremy D. Keenan, MD, MPH; Bennie H. Jeng, MD, MS
In Reply There is no gold standard or widely accepted staining protocol for assessing endothelial cell death in human corneas after storage. We followed the vital dye staining protocol proposed by Park et al,1 who validated the ability of trypan blue to detect endothelial damage by comparing corneas exposed to ...
Original Investigation 
William G. Christen, ScD; Robert J. Glynn, ScD; J. Michael Gaziano, MD; Amy K. Darke, MS; John J. Crowley, PhD; Phyllis J. Goodman, MS; Scott M. Lippman, MD; Thomas E. Lad, MD; James D. Bearden, MD; Gary E. Goodman, MD; Lori M. Minasian, MD; Ian M. Thompson Jr, MD; Charles D. Blanke, MD; Eric A. Klein, MD
Includes: Supplemental Content

Importance  Observational studies suggest a role for dietary nutrients such as vitamin E and selenium in cataract prevention. However, the results of randomized clinical trials of vitamin E supplements and cataract have been disappointing and are not yet available for selenium.

Objective  To test whether long-term ...

Original Investigation 
Lindsay N. Boyers, BA; Chante Karimkhani, BA; John Hilton, MSc, MPhil; William Richheimer, MD; Robert P. Dellavalle, MD, PhD, MSPH
Includes: Supplemental Content

Importance  Eye and vision disease burden should help guide ophthalmologic research prioritization. The Global Burden of Disease (GBD) Study 2010 compiled data from 1990 to 2010 on 291 diseases and injuries, 1160 disease and injury sequelae, and 67 risk factors in 187 countries. The Cochrane Database of ...

Original Investigation 
Nicolas A. Yannuzzi, MD; Michael A. Klufas, MD; Lucy Quach, BS; Lauren M. Beatty, BA; Stephen M. Kaminsky, PhD; Ronald G. Crystal, MD; Donald J. D’Amico, MD; Szilárd Kiss, MD

Importance  Bevacizumab acquired from compounding pharmacies for intravitreal injection may cause infectious and noninfectious inflammation. In addition to safety issues, the drug itself may have variable efficacy associated with product aliquoting, handling, and distribution.

Objective  To conduct surveillance cultures, evaluate endotoxin levels, and assess protein concentrations ...

Brief Report 
Fook Chang Lam, MRCP, FRCOphth; Lamis Baydoun, MD; Martin Dirisamer, MD; Jessica Lie, PhD; Isabel Dapena, MD, PhD; Gerrit R. J. Melles, MD, PhD

Importance  This study evaluates the technical feasibility and clinical outcomes of a Descemet membrane endothelial keratoplasty (DMEK) technique that could increase the availability of donor tissue for DMEK.

Objective  To evaluate the clinical outcome of using a semicircular, large-diameter Descemet membrane graft in DMEK (hemi-DMEK), potentially ...

Ophthalmic Images 
Vivian Lee, MD; Benjamin J. Kim, MD
Graphic Jump LocationA woman in her early 70s with a retinal detachment for 3 months underwent repair, when a subretinal, soft mass was identified. Histopathologic analysis demonstrated birefringent crystals consistent with calcium oxalate, an uncommon finding with chronic detachments (hematoxylin-eosin, original magnification ×10 [A]; polarized light, original magnification ×10 [B]). ...
Topics: eye
Comment & Response 
Richard C. Allen, MD, PhD; Ryan J. Wise, MD
To the Editor We read with special interest the article titled “Botulinum Toxin Type A Injection for Lateral Canthal Rhytids: Effect on Tear Film Stability and Tear Production” by Ho et al1 and offer additional support for the mechanism by which botulinum toxin injection may alter the functioning of the ...
Observation 
Hakan Demirci, MD; Joshua S. Grant, MD; Victor M. Elner, MD, PhD
Primary B-cell mucosa-associated lymphoid tissue (MALT) lymphoma of the iris is rare. The largest published series of 14 iris lymphomas included 3 such lymphomas.1 Thus, data concerning the effectiveness of treatment of these tumors are limited. External radiotherapy (the main treatment), resection, and systemic chemotherapy can cause substantial morbidity. Rituximab ...
Original Investigation 
Robert Burgmeier, BS; Rajen U. Desai, MD; Katherine C. Farner, BS; Benjamin Tiano, BS; Ryan Lacey, BS; Nicholas J. Volpe, MD; Marilyn B. Mets, MD
Includes: Supplemental Content, Multimedia: (powerpoint)

Importance  Children with a history of amblyopia, even if resolved, exhibit impaired visual-auditory integration and perceive speech differently.

Objective  To determine whether a history of amblyopia is associated with abnormal visual-auditory speech integration.

Design, Setting, and Participants  Retrospective observational study at an academic pediatric ophthalmologic ...

Original Investigation 
De-Kuang Hwang, MD, PhD; Catherine Jui-Ling Liu, MD; Cheng-Yun Pu, PhD; Yiing-Jenq Chou, MD, PhD; Pesus Chou, DrPH

Importance  Medication persistence is an important factor for treatment effect in patients with glaucoma. Evaluating risk factors for refill discontinuation might be helpful for improving persistence and preventing blindness in patients with glaucoma.

Objectives  To estimate the persistence rate with topical glaucoma medication 2 years after ...

Surgical Technique 
Atsuhiro Tanikawa, MD; Masayuki Horiguchi, MD
Almost all cataract surgical procedures rely on phacoemulsification, which requires favorable lens visibility. Visibility can be negatively affected by various ocular pathologies including dense vitreous hemorrhage. When the microscope light source reflects off the ocular fundus, the lens is transilluminated. In the presence of dense vitreous hemorrhage, light cannot adequately ...
Ophthalmic Images 
Lucio Zeppa, MD; Luigi Ambrosone, MD; Germano Guerra, MD; Michele Fortunato, MD; Ciro Costagliola, MD
Graphic Jump LocationA microcatheter filled with 1.25 μg of indocyanine green (ICG) diluted in 1 mL of viscoelastic solution was placed into the Schlemm canal (SC) to enlarge the drainage canal; the dye was then injected into the SC. Near-infrared fluorescence real images of aqueous humor outflow structures in in ...
Topics: aqueous humor; eye
Observation 
Christine Y. Chen, PhD; Michael Engelbert, MD; K. Bailey Freund, MD; Carol L. Shields, MD; Gaetano Barile, MD
Laser photocoagulation–induced choroidal neovascularization (CNV) is an uncommon iatrogenic complication following thermal laser treatment for diabetic macular edema and proliferative diabetic retinopathy.1 Disruption of the retinal pigment epithelium–Bruch membrane complex due to intense laser energy presumably leads to the development of CNV.1,2 We report a dramatic case of laser-induced CNV ...
Original Investigation 
Stefano A. Gandolfi, MD; Nicola Ungaro, MD; Maria Grazia Tardini, AO; Stella Ghirardini, AO; Arturo Carta, MD; Paolo Mora, MD

Importance  Prospective long-term analyses of the role of drug-induced mydriasis and laser peripheral iridotomy (LPI) are needed to identify and manage the eyes of patients with pigment dispersion syndrome (PDS) at risk for progressing to ocular hypertension.

Objective  To assess the 10-year incidence of increased intraocular ...

Original Investigation 
Louis R. Pasquale, MD; Aliya Z. Jiwani, MD; Tzukit Zehavi-Dorin, MD; Arow Majd, MD; Douglas J. Rhee, MD; Teresa Chen, MD; Angela Turalba, MD; Lucy Shen, MD; Stacey Brauner, MD; Cynthia Grosskreutz, MD, PhD; Matthew Gardiner, MD; Sherleen Chen, MD; Sheila Borboli-Gerogiannis, MD; Scott H. Greenstein, MD; Kenneth Chang, MD; Robert Ritch, MD; Stephanie Loomis, MPH; Jae H. Kang, ScD; Janey L. Wiggs, MD, PhD; Hani Levkovitch-Verbin, MD, MPA

Importance  Residential (geographic) history and extent of solar exposure may be important risk factors for exfoliation syndrome (XFS) but, to our knowledge, detailed lifetime solar exposure has not been previously evaluated in XFS.

Objective  To assess the relation between residential history, solar exposure, and XFS.

Design, ...

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