http://archopht.jamanetwork.com/ en-us Mon, 13 Aug 2012 00:00:00 GMT Tue, 01 Jan 2013 00:52:59 GMT Silverchair editor@archopht.jamanetwork.com webmaster@archopht.jamanetwork.com http://archopht.jamanetwork.com/article.aspx?articleID=1106440 Thu, 01 Sep 2011 00:00:00 GMT Zhu H, Crabb DP, Fredette M, et al. <span class="paragraphSection"><div class="boxTitle">Objective</div>To evaluate a new method of quantifying and visualizing discordance between structural and functional measurements in glaucomatous eyes by predicting the visual field (VF) from retinal nerve fiber layer thickness (RNFLT) using a bayesian radial basis function.<div class="boxTitle">Methods</div>Five GDx VCC RNFLT scans and 5 Humphrey 24-2 Swedish Interactive Thresholding Algorithm VF tests were performed for 50 glaucomatous eyes from 50 patients. A best-available estimate (BAE) of the true VF was calculated as the pointwise median of these 5 replications. This BAE VF was compared with every RNFLT-predicted VF from the bayesian radial basis function and every measured VF. Predictability of VFs from RNFLT was established from previous data. A structure-function pattern discordance map and a structure-function discordance index (scores of 0-1) were established from the predictability limits for each structure-function measurement pair to quantify and visualize the discordance between the structure-predicted and measured VFs.<div class="boxTitle">Results</div>The mean absolute difference between the structure-predicted and BAE VFs was 3.9 dB. The mean absolute difference between measured and BAE VFs was 2.6 dB. The mean (SD) structure-function discordance index score was 0.34 (0.11). Ninety-seven (39%) of the structure-predicted VFs showed significant discordance (structure-function discordance index score >0.3) from measured VFs.<div class="boxTitle">Conclusions</div>On average, the bayesian radial basis function predicts the BAE VF from RNFLT slightly less well than a measured VF from the 5 VFs composing the BAE VF. The pattern discordance map highlights locations with structure-function discordance, with the structure-function discordance index providing a summary index. These tools may help clinicians trust the mutually confirmatory structure-function measurements with good concordance or identify unreliable ones with poor concordance.</span> 129 9 1167 1174 10.1001/archophthalmol.2011.112 http://archopht.jamanetwork.com/article.aspx?articleID=1106440